Joy@ Reversing Insulin Resistance

Sardines are not a high mercury food. You’d need to eat *77* servings of sardines to get the mercury in one serving of swordfish. Second, the forms of selenium in some fish are thought to at least partially offset some of the presumed harms of mercury in fish, making the natural selenium/mercury a potentially relevant metric. Eg Mahi Mahi has as high ratio ~13:1, if I recall. Third, for those still concerned, broken-cell wall chlorella when consumed with fish can act as an efficient chelating agent. TL;DR - Chillax yo 😆. My mercury is fine. But thanks for your concern. And I’ve added this table to the letter, which is surprisingly popular on Day 1… the video is going to be even more fun open.substack.com/pub/staycuriou…

(1/10) The Big Cardiology news this week:  The PCSK9 inhibitor Evolocumab reduces risk of  Major Adverse Cardiovascular Events by 25% (relative risk) in a new RCT published in the New England Journal of Medicine. (Links🔗 at the end) The finding is being widely framed as a massive win for "primary prevention." However, it’s important to emphasize that these were high-risk patients. In fact, the trial title itself—“Effects of Evolocumab in Patients at High Risk of Cardiovascular Disease…” (clinical trials . gov)—makes that explicit. To qualify, participants had to have at least one of the following: 🫀Coronary artery disease 🫀Atherosclerotic cerebrovascular disease 🫀Peripheral artery disease 🫀High-risk diabetes

The "misinformation" on diet started with Ancel Keys and has yet to be corrected

Cholesterol Myth: What Really Causes Heart Disease Most people think cholesterol is the main cause of heart disease  but that’s a myth. As a heart surgeon explains, arterial plaque contains more than just cholesterol, including calcium, clots, and inflammation. Learn what truly damages blood vessels and how understanding these factors can help prevent and even reverse heart disease.  @ThePrimal_Pod #HeartHealth #CholesterolMyth #PreventHeartDisease #CardiovascularHealth #HeartSurgery #Inflammation #HealthyHeart

Calories Don’t Cause Obesity — (I'm Doubling Down) Now that I’ve managed to irritate half of Nutrition Twitter (and have the other half shouting “say it louder for the people in the back”), let me add some nuance. Yes — surprise, surprise — a short reel is engagement bait. That’s the point. So put you emotions in a box and let's think through this... If I overeat by 2,000+ calories on a ketogenic diet, here’s what happens: ❤️‍🔥My heart rate and body temperature rise 🔥I feel jittery and burn off the excess energy 💩Some studies even suggest that certain microbiome shifts can lead to greater fat excretion in feces. Now, sure — one could argue retrospectively that this is still “calorie balance,” since my energy expenditure increased to match my energy intake. So calories win, right? ❌ Wrong. Because that logic only works after the fact. A good biological model doesn’t just describe what happened — it predicts what will happen. And “calories in, calories out” does not predict who develops *chronic* obesity. Let's double click on *chronic* obesity... Short overfeeding studies don’t model real-world obesity. Forcing someone to eat 10,000 calories of any food doesn’t capture the slow, subtle metabolic dysregulation that underlies obesity. The same goes for starvation studies — the body adapts massively at every level, from fat cells to brain signaling to the microbiome. This complexity and lack of simple unifying explanation intimidates people, so they cling to simple arithmetic: “energy balance.” But here’s the truth: Chronic calorie balance is not the "cause" of obesity. It’s the consequence. It’s the dependent variable — the math you do after biology has already made its decisions. If you don’t get that, reread this post 12 times until it sinks in. Or don’t. If you’d rather live on tuna and celery sticks, that’s your call. 😉

Science is a team sport, and our team is rocking it As a moment of open reflection, it feels wild to me that in just a few months since I graduated medical school and doubled-down on providing public science education, our #StayCurious community (on Substack) has consistently ranked at the top of Rising Science and is rocketing 🚀 up the overall bestsellers list. 🚨Let me be clear: this is not a celebration of self—far from it. Rankings can often be shallow signals. But here I feel it reflect the breadth and depth of your enthusiasm for nuanced science. I know it’s not easy. I never expected my enthusiasm for all things metabolism to be reflected back at me with such force. What I’m trying to say it your are more motivating and inspiring than you can imagine. This isn’t a victory lap, because we’ve only just gotten started. So thank you, #StayCurious family.

Is your High LDL-Cholesterol clogging your heart arteries?? Here's the latest research on this touchy question. Watch: youtube.com/live/6rfiLvrlo…

Some people have said the CDC is not responsible for advice to prevent chronic disease. Yet, CDC has an entire division called the National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP). This includes the Diabetes Prevention Program, whose guidance is followed by all diabetes educators in the country. Its current guidance is to eat a high-carb, low-fat diet to prevent T2 diabetes. This is outdated. This diet may slow the progression of this disease, but for at least a decade, there's been solid science to show that prediabetes can be reversed with a ketogenic diet. The DPP urgently needs an update.

Eating healthy doesn't have to be expensive. Costco is now selling a pound of grass-fed and finished beef for less than a McDonalds Big Mac. h/t @thecarnivorebar ·

If a doctor prescribes a pill before asking about your diet, that doctor is practicing pharmaceuticals, not medicine.

🚨All Keto-CTA Analyses are in!🚨 In this preliminary presentation I cover: 📆 Updates to date on study 🤔 "Lack of contrast" assertion 🔥 Incredible new data on confirmed regression ⚠️ Reminder on subset of progressors ✅Next steps for the research youtu.be/aJobOSRdIOM

One of my coolest memories. Sharing the stage at Low Carb for Better Health in Tennessee with Kim Howerton, @TuitNutrition ,@KenDBerryMD , Neisha Maria Salas-Berry, @ChrisPalmerMD, Mark Cucuzzella, and my bestie @carbaddictcoach. These are all people I love and admire, who have taught me a great deal about metabolic disease and how to reclaim my health. I think there are still a few tickets left for this year's event (September 12-13th). @deckerlesscarbs was able to secure amazing speakers. Check them out at lc4bh.com

Just so you all know, Type 2 diabetes is not chronic progressive. I’ve been off insulin for over 5 years. A1c was 8.5. I am no longer diabetic. Screenshot 1 hour after breakfast, which, shocker, included some carbs.

People with diabetes are hungry for helpful advice and now they have a place they can get it, the @OfficialADSOrg Their delicious recipes make your blood sugar go down!

Gary Taubes, one of my favourite speakers, on The Stickiness Problem: A History of Metabolic/ Ketogenic Therapies and the Challenge to Acceptance and Use at @lowcarbusa in San Diego.

Dr. Csilla Ari D'Agostino on stage at the Symposium for Metabolic Health in San Diego: Neuroprotection and Neuroregeneration with Ketone Metabolic Therapies @lowcarbusa

It’s official, all four analyses are now in — including our long awaited, prespecified methodology for Keto-CTA, MEDIS QAngio. I’ll be presenting these at @TheSMHP conference this weekend in San Diego.

SUGAR AND BLOOD PRESSURE: People with high blood pressure are told to restrict salt. Should they also be told to restrict sugar? Fructose converts to uric acid, which decreases nitric oxide(NO). Glucose raised insulin. Increased insulin retains salt. Both increase blood pressure. h/t @Wegiveyouhealt1

Obesity Rewires Your Brain, Your Kidneys, and Your Blood Pressure (Full content🔗in 5/5; And 3/5 will freak you out 🫣) 1/5) For decades, we’ve been told to cut back on salt to control blood pressure. The U.S. Dietary Guidelines still recommend limiting sodium intake to 2.3 grams per day. But the science behind this advice is far from settled. In fact, some long-term studies suggest the opposite: that lower sodium intake associates with higher blood pressure. (reference in letter, linked at the end). And—curiously—people with obesity tend to be more salt-sensitive than lean individuals. Why? I promise, we’re going to unpack these questions today in the letter, and give you enough knowledge to terrify your cardiologist and woo your nephrologist. #salt #bloodpressure #hearthealth #electrolytes @robbwolf @realDaveFeldman

🔥 New Blog: Natural Solutions for Metabolic Health 🔥 @MichelleHurnRD on insulin resistance, protein, fat, fibre, movement, sleep and practical ways to cut cravings. tinyurl.com/kzczew9v