Arvind Sharma

Model for bnAb C10 bivalent binding👇 C10 recognizes the icosahedral epitope distribution - its Fab arms cross-link the 3 fold symmetry axis related epitopes. 30 mAbs to neutralize one #dengue or #Zika virion. @virusfusion007 More in @CellCellPress 👇

Heartiest Congratulations Priyanka ….With this publication, you have become one of the few in the world and probably the only one from India to have first-author publications of #protein-nucleic acid complex #structures solved by #CryoEM, X-ray #crystallography, and liquid-state #NMR spectroscopy. 𝑰 𝒂𝒎 𝒑𝒓𝒐𝒖𝒅 𝒐𝒇 𝒚𝒐𝒖…..

Excited to share my first-author paper, now published in #NAR as a Breakthrough Article! 🎉 📖 Read the full study: lnkd.in/ert6FmPv #NARBreakthrough #CryoEM #ChromatinRemodeling #StructuralBiology #INO80 #Nucleosomes #GeneExpression

Delighted to be part of this study and grateful to the editors who recognized its potential and selected it as a Breakthrough Article. Recognition and remodelling of nucleosomes and hexasomes by the human INO80 complex academic.oup.com/nar/article/54…

We are looking to recruit a postdoctoral researcher to work in my group in the Institut Pasteur (Paris), a great place to learn new techniques and establish collaborations. More information here: research.pasteur.fr/en/job/postdoc… If you know someone interested, please share the link.

We are looking for 2 junior postdocs to work on our EU projects: yellow4FLAVI (yellow4flavi.eu) and new project SHIELD. You will be based @PasteurVirology in 🇫🇷 and be part of a dynamic group research.pasteur.fr/en/team/flavim… #YFV @PostdocJobs #jobopening #JobOpportunity #JobAlert

Have you heard of the ongoing outbreak of feline infectious peritonitis (FIP) that claimed the lives of ~10,000 cats in Cyprus and was imported to the UK? Learn about it and its causative coronavirus (FCoV-23) in our study led by @aletortorici 1/17 biorxiv.org/content/10.110…

Delighted to see the artwork by @SaundersNell1 displayed at the @CellCellPress cover page! It illustrates the work by @virusfusion007 and our lab on HKU1 binding to its receptor. Commentary on this study and two other papers: cell.com/cell/abstract/… Congrats to @SaundersNell1

Congrats to Ignacio Fernandez, @SaundersNell1 @virusfusion007 and great collaborators, for deciphering the structural basis of TMPRSS2 activation and recognition by the HKU1 seasonal #coronavirus. cell.com/cell/fulltext/…

In a great collaboration with @HummerLab and the Kräusslich lab, @jpkreysing, @MaziarHeidari1, @VojtechZila and others tackle what happens when HIV capsid goes through an NPC. Instead of the NPC cracking the capsid, the capsid appears to crack the NPC (@MPIbp @CiidHeidelberg).

Modulation of SARS-CoV-2 spike binding to ACE2 throughconformational selection biorxiv.org/cgi/content/sh… #biorxiv_biophys

We are looking for a junior postdoc to work on our EU project yellow4flavi.eu You will be based @PasteurVirology in 🇫🇷 and interact with researchers from 🇮🇹🇩🇪🇨🇴🇧🇪🇳🇱🇫🇮 #YFV @PostdocP @PostdocJobs #jobopening #JobOpportunity #JobAlert

Happy to share our latest preprint describing how RBD dynamics of #SARSCoV2 spike protein affects binding to ACE2. Collaboration between @virusfusion007 @CharlieGosse and @Terence_Strick and our lab @FM4B_Lab. biorxiv.org/content/10.110…

Immunity to Flaviviruses?......it's complicated! Check Antonio Santos-Peral work about YF17D vaccination in the context of prior flavivirus immunity rdcu.be/dzu6L @NatureComms @PasteurVirology Another great collaboration with #Rothenfusserlab @AnneKrug5 @kischober #YFV

It's raining HKU1 papers! ☔️ Very nice work from Fernandez et al. Congratulations to all the authors! 🎉 I particularly like the experiment shown in panel 1H, which supports the model we proposed in our recent paper: nature.com/articles/s4158…

The follow-up story on TMPRSS2 and HKU1 is out ! Crystallography, mutations, tropism study, nanobodies and more cool results can be found there -> biorxiv.org/content/10.110… Big up to Ignacio Fernandez and the teams @virusfusion007 and @Virus_Immunity

Excited to share the pre-print describing our efforts to stabilize the HCMV gB ectodomain in a prefusion-like conformation. We and others have now routinely stabilized class I viral fusion proteins, but class III viral fusogens have been more difficult.

Do you want to study viruses by CryoEM ❄️🔬? Do you love art, food and history 🎭🍷🏰? We are hiring!

Virion morphology and on-virus spike protein structures of diverse SARS-CoV-2 variants biorxiv.org/cgi/content/sh… #bioRxiv

🦟🌍 Dengue virus is spreading globally, even in Europe! In 2023, Italy saw a record high in dengue cases. Our latest research introduces a data repository and delves into circulating viral lineages, hotspots, and climate impacts! @LourencoJML <3 and the dream team!

@MaxxRenner Congratulations, Max!