Hummer Lab

66 posts

Hummer Lab

@HummerLab

Molecular simulations and computational biophysics @MPIbp

Frankfurt, Germany Katılım Haziran 2021

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IBC2@IBC2_GU·28 Eki

A multidisciplinary team around @RamBhaskara4 from @IBC2_GU @goetheuni provides fresh insights into the role of intrinsic disorder in large-scale membrane shaping during ER-phagy. @HummerLab @DikicLab @EnableFrankfurt @sfb1177 @SCALE_Uni_FFM

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Di Wu@MiChAeL_900922·22 May

Happy to share our latest study in @Nature revealing how FLVCR1 & FLVCR2 transport choline & ethanolamine, and shedding light on their roles in related rare diseases. Two in One! 🔬 Read more: nature.com/articles/s4158… Great teamwork with @SafarianSchara @HummerLab @nguyenln_ 💪

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Sergio Cruz-León@SergioCruzLeon1·14 May

We are excited to announce the publication of high confidence 3D template matching for #cryoET @HummerLab @Beck_Laboratory @jpkreysing @geissler_katha @s_l_schaefer @pc_hoffmann @MPIbp @cziscience Paper's link: nature.com/articles/s4146… See it in action in our short video!

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Max Planck Institute of Biophysics@MPIbp·14 May

Congratulations!!!👏😀

Sergio Cruz-León@SergioCruzLeon1

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Beck Laboratory@Beck_Laboratory·24 Nis

In a great collaboration with @HummerLab and the Kräusslich lab, @jpkreysing, @MaziarHeidari1, @VojtechZila and others tackle what happens when HIV capsid goes through an NPC. Instead of the NPC cracking the capsid, the capsid appears to crack the NPC (@MPIbp @CiidHeidelberg).

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Ram Bhaskara@RamBhaskara4·29 Mar

Our team’s latest research on IDRs in membrane remodeling. #membraneremodeling #ERphagy @HummerLab @DikicLab

bioRxiv@biorxivpreprint

Intrinsically disordered region amplifies membrane remodeling to augment selective ER-phagy biorxiv.org/cgi/content/sh… #bioRxiv

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Max Planck Institute of Biophysics@MPIbp·28 Mar

Heartfelt congrats to our group leader @eugene_kim__ (@EKimlab) on receiving the Heinz Maier-Leibnitz Prize, one of the most important awards for early-career researchers, for her research on genome packaging! #biophysics @dfg_public @maxplanckpress 👉 biophys.mpg.de/eugene-kim-hei…

Max Planck Institute of Biophysics tweet media

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Max Planck Institute of Biophysics@MPIbp·11 Mar

#ATP, the energy currency of cells, is produced by the mitochondrial protein ATP synthase. Our @HummerLab provides new insights into the structural mechanism and energetics of the crucial proton-driven c-ring rotation by atomistic free energy calculations👉pnas.org/doi/10.1073/pn…

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Matt Sikora@BioPhysMatt·29 Şub

a true adventure and privilege to work Danny's team and colleagues (cryoEM, MS, SAXS) @IBCSinica @asibc512 @AcadSinica @khooAS @TzuJingYang @SKCM2_HU @KarenMinfenghsu big MD from @HummerLab @_mischi @SoBuelow enhanced sampling from @Isa_Grothaus @hmi_group and amazing @vidseh

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Hurley Lab@TheHurleyLab·26 Şub

🚨Now in print!🚨Sankalp Shukla @Sankalp Shukla_ in collaboration with @PIHanson lab and @HummerLab probes the mechanistic and cellular implications of direct membrane binding by the ESCRT and ERES associated Ca2+- sensor ALG- 2 protein. Read it: pnas.org/doi/10.1073/pn… @PNASNews

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Max Planck Institute of Biophysics@MPIbp·13 Şub

Video by S. Rao: All-atom molecular dynamics simulation of the membrane-recruited ATG12-ATG5-ATG16L1-WIPI2 complex loaded with the ATG3-LC3 conjugate. Congratulations to all authors from @LazarouLab, @TheHurleyLab and @HummerLab on this amazing publication in @ScienceAdvances!

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Max Planck Institute of Biophysics@MPIbp·13 Şub

S.Rao from our @HummerLab & coworkers resolve mechanism of LC3 delivery to the phagophore membrane, a key step in selective #autophagy, by combining #MDsimulations & experiments. Three-step targeting of ATG12-ATG5-ATG16L1 machinery leads to LC3 lipidation👉science.org/doi/10.1126/sc…

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Max Planck Institute of Biophysics@MPIbp·4 Eki

Scientists from the MPI of Molecular Physiology (@mpimoph) and from our Department of Theoretical #Biophysics (@HummerLab) have identifed a region in actin that functions as a “molecular backdoor” for phosphate to exit through! 👉 biophys.mpg.de/2768357/throug…

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Wout Oosterheert@WoutOosterheert·25 Eyl

Very excited that our manuscript is now online @NatureSMB! nature.com/articles/s4159… We show how actin filaments release inorganic phosphate (Pi) through a “molecular backdoor” and demonstrate that the backdoor is distorted in a disease-linked actin variant. A thread (1/17)

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Hurley Lab@TheHurleyLab·29 Eyl

New preprint! @AutophaZeke’s PI3KC3-C1/RAB1A structure reveals that VPS15 is a GTP-binding pseudokinase that repurposes the kinase fold to regulate a myristoylation, and stabilize a large rotation in the VPS34 lipid kinase to promote membrane binding and PI(3)P synthesis!

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Hurley Lab@TheHurleyLab·1 Eki

The 2024 Gordon Conference on Autophagy will be held at the beautiful Il Ciocco site in Tuscany Mar. 10-15. If you have a passion for autophagy or just want to learn more, apply now before it gets oversubscribed! tinyurl.com/mu9dmc6w

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Beck Laboratory@Beck_Laboratory·8 Eyl

Detection of various complexes in cryo electron tomograms. Great work by @SergioCruzLeon1 and others now online. @MPIbp #teamtomo #cryoem @ChanZuckerberg

Sergio Cruz-León@SergioCruzLeon1

🧵[1/6] We achieve high-confidence localization of a wide range of macromolecular complexes, their subunits, and functional substates through 3D template matching (TM) for #CryoET. This allows us to capture vaults transporting ribosomal cargo in situ!🤯 doi.org/10.1101/2023.0…

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Max Planck Institute of Biophysics@MPIbp·29 Ağu

The role of CydDC, a potential target for new antibiotics, in the bacterial energy metabolism has remained nebulous for decades. Scientists from our Institute, @ALIFE_VU, @UGent, @UniKent solved the riddle: CydDC is a heme transporter👉biophys.mpg.de/cyddc #biophysics #cryoEM