G.Osborne

286 posts

G.Osborne

G.Osborne

@Asclepius7TM

GPCR pharmacology with structure based drug design 👍

Cambridge,UK Katılım Aralık 2015
247 Takip Edilen226 Takipçiler
G.Osborne retweetledi
Nxera Pharma
Nxera Pharma@NxeraPharma·
We are pleased to announce that we have reached an important R&D milestone under our multi-target discovery collaboration with @AbbVie targeting #neurologicaldiseases, resulting in a payment of US$10m to Nxera. bit.ly/4cdDr3M
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National Highways: East
National Highways: East@HighwaysEAST·
Traffic has temporarily stopped on the #M11 northbound between J10 (#Duxford) and J11 (#Cambridge) due to a collision causing barrier damage. @CambsCops are in attendance. There are delays of at least 20 minutes on approach.
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G.Osborne retweetledi
Nxera Pharma
Nxera Pharma@NxeraPharma·
Our partner @pfizer has entered a new oral small molecule GLP-1 receptor agonist into a Phase 1 clinical trial. PF-06954522 was discovered during a multi-target research collaboration in which Pfizer had access to our proprietary StaR technology. bit.ly/3MwvUm1 #GLP1
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Nxera Pharma
Nxera Pharma@NxeraPharma·
Today we are excited to announce the acquisition of Idorsia’s pharmaceuticals business in Japan and APAC (ex-China), accelerating our transformation into a fully integrated biopharmaceutical company. Read our full announcement here: bit.ly/43sKtMU
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G.Osborne retweetledi
Nxera Pharma
Nxera Pharma@NxeraPharma·
We are delighted to announce we have received approval to change Sosei’s market listing to the Tokyo Stock Exchange Prime Market from the Growth Market segment effective 15 March 2023. For further details please see the Japan Exchange Group’s website (jpx.co.jp/english/).
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G.Osborne retweetledi
Keith Hornberger
Keith Hornberger@KRHornberger·
If you read one pharmacology paper in January, make it this one that was sent my way by @pwk2013. Although it speaks about the difficulty of measuring intracellular free drug concentrations, it’s largely a defense of the free drug hypothesis. 1/6 dmd.aspetjournals.org/content/47/6/6…
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G.Osborne retweetledi
Nxera Pharma
Nxera Pharma@NxeraPharma·
We are pleased to announce that our partner @pfizer has dosed the first subject in a Ph2 clinical trial with its candidate PF-07081532 for the treatment of Type 2 #diabetes and #obesity. This milestone triggers a payment of US$10 mio to Sosei Heptares. bit.ly/3jfW68y
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G.Osborne retweetledi
Nxera Pharma
Nxera Pharma@NxeraPharma·
We are delighted to announce a multi-target drug discovery collaboration with @LillyPad to discover small molecules that modulate novel G protein-coupled receptor (#GPCR) targets associated with #diabetes and #metabolic diseases. Read the full PR: bit.ly/3WkUQ23
Nxera Pharma tweet media
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G.Osborne retweetledi
Nxera Pharma
Nxera Pharma@NxeraPharma·
Centessa's novel agonists were developed using structure-based design with an OX2R protein stabilized in agonist conformation using our StaR® Technology. We are pleased to see progress of molecules designed using our technology and look forward to seeing further advancement.
Centessa Pharmaceuticals@centessa

Today we announced a poster presentation of data from our oral small-molecule orexin receptor 2 (OX2R) agonist discovery pipeline at #SleepEurope 2022. The poster will be presented in Athens on Thurs., Sept. 29 at 12:15pm EEST. Read our press release: investors.centessa.com/news-releases/…

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G.Osborne
G.Osborne@Asclepius7TM·
@chrislangmead this is basically the same as someone asking for a new bit of research until you give in..then it doesn’t work and they want to drop it - what I am saying is..your career has trained you for children mate 😂
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Prof. Chris Langmead
Prof. Chris Langmead@chrislangmead·
Ethan pestered me non-stop all day for burger and chips. I finally relented and got him and Grace kids’ burger and fries for dinner. THE LITTLE SOD WOULDN’ T EAT THE BURGER. SAID HE “DOESN’T LIKE BURGERS”. PLEASE SEND ME THE PATIENCE I NEED NOT TO PUT MY KIDS OUT ON THE STREET.
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G.Osborne retweetledi
Nxera Pharma
Nxera Pharma@NxeraPharma·
We are pleased to announce that the IND application for a Phase 2 clinical trial of NBI-1117568 for the treatment of #schizophrenia​, in collaboration with @neurocrine, has been accepted by the @US_FDA. View PR:bit.ly/3vFb37o
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G.Osborne retweetledi
Nxera Pharma
Nxera Pharma@NxeraPharma·
We are delighted to announce we have entered a new multi-target collaboration with @abbvie to discover, develop and commercialize small molecule therapeutics targeting GPCRs associated with neurological disease. View PR: bit.ly/3Jl9tgw
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G.Osborne
G.Osborne@Asclepius7TM·
I am recruiting to grow our Pharmacology team in Cambridge UK in order to support a growing portfolio of exciting GPCR drug discovery programs. If you are completing a PhD, postdoc or are in industry/biotech & interested in this opportunity pls reach out!! linkedin.com/jobs/view/3195…
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G.Osborne retweetledi
Nxera Pharma
Nxera Pharma@NxeraPharma·
We are thrilled to have signed an agreement with @CR_UK to advance HTL0039732 into a Phase I/IIa clinical trial, evaluating this drug candidate in combination with other immunotherapies to treat a wide range of cancers. soseiheptares.com/news/783/129/C…
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Keşfet

@abbvie @HighwaysEAST @CambsCops @pfizer @pwk2013 @LillyPad @chrislangmead @neurocrine