Isacco Desideri

Day FOUR of #ESTRO26 Coverage by OncoAlert 🚨 PERSIAN TRIAL (NCT03449719): a randomized phase II trial testing Apalutamide and SBRT for hormone-sensitive prostate cancer Presented by Giulio Francolini 🇮🇹 #RadOnc ☢️ The PERSIAN randomized phase II trial evaluated apalutamide ± SBRT in oligometastatic hormone-sensitive prostate cancer. Biochemical response rates were high in both arms, with no significant differences overall. A consistent numerical trend favoring SBRT was observed, particularly in patients with higher disease burden. Treatment was well tolerated, with limited interruptions. These findings suggest a potential role for SBRT alongside systemic therapy in selected patients. @ESTRO_RT @yasemin09896924 @LindaMrissa @christian_roenn @Valeriadionisi @gerryhanna @clchiang_hk @mtugceyilmaz @B_Tomasik @gmpetrianni @CiroFranzese1 @Atem84 @piet_ost @brachyexpert @BlanceS90 @The_PT_Explorer @BarbaraJereczek @Mat_Guc @ZilliThomas @AnnaKirby17 @PBlanchardMD @achoud72 Pinging OA faculty @MKnoll_MD @_ShankarSiva @Icro_Meattini @seanmmcbride @NiuSanford @nataliagandur @acampsmalea @to_be_elizabeth

Join us in sending birthday greetings to the guitarist as we build a RF@80 song playlist celebrating his 80th year. Find out more at dgmlive.com/news/happy-bir…

It sucks to see that the last time my recent repack posts (excluding reposting old ones) ever reached 100k views was more than a month ago, and even games like halo 2 (whose predecessor had 1m views) couldn't even reach 50k. Even changing to new format didn't helped so I'll stick to old one ig.

#ESTRO26 - INTRAGO phase III trial Dr Frank Giordano investigated that dose escalation in #glioblastoma #braincancer. Using single fraction intra-operative #radiotherapy dose escalation did not improve outcomes. Congrats to authors completing this challenging trial!

Agreed. GBM is unfortunately a much more complex disease to be effectively treated only by tweaking dose and volume. #ESTRO2026

No improvement in oncological outcomes with intraoperative dose escalation in GBM patients. Time to shift from dose and volume to other approaches in this uncurable disease. #ESTRO2026

Long term outcomes of conventional fractionated re-irradiation in recurrent pediatric ependymomas: prolongs survival but concerns regarding long-term complications. #ESTRO2026

What is the role of reirradiation for recurrent meningioma? Read our systematic review and meta‑analysis in @Advances_ASTRO! @ASTRO_org @ESTRO_RT @LabRaleigh @joostverhoeff advancesradonc.org/article/S2452-…

2/ Interesting proof of concept multicentric trial just discussed in a lively CNS proofered paper session #ESTRO2026

1/ Promising targeted strategy in unmethylated GBM addressing both vasculogenesis (NOX-A12) and angiogenesis (Bevacizumab) #ESTRO2026 @OncoAlert

Inferior oncological outcomes as well as Qol

Non-inferiority was not demonstrated with 6x6Gy vs 30x2Gy in GBM patients #ESTRO2026

For people who want Dishonored3: rejoice, wait no more: Elon Musk just said gamers will be able to generate GTA6 before GTA6 comes out in minutes thanks to AI, so D3 should be a walk in the park. Right?

I do not believe this story.

Respect Italy ✊

Editorial CATNON IDHmt Grade 3 Astrocytoma · NO benefit concurrent temozolomide · Sig benefit w/adjuvant TMZ · MGMT NOT prognostic · Poor prog CDKN2A/B homo deletion, PDGFRA amp, methy profile academic.oup.com/neuro-oncology…

That moment in a game when you know you were about to play a masterpiece

In MD Anderson, we have treated all SBRT consecutive days including 54 Gy in 3 FX, 50 Gy (SIB GTV 60 Gy) in 4 Fx, 50 Gy (SIB GTV 60 Gy) in 5 Fx. We don’t observe any particular concerns for side effects and it is much convenient for our patients.

Nobody: Absolutely nobody: Post SBRT lung sitting there for the last 3 years as fibrosis: 👁️👄👁️ Radiologist: “cannot exclude residual disease, clinical correlation recommended, suggest PET/CT, bronchoscopy, repeat CT in 6 weeks, and carrier pigeon to oncologist”

@RyanAFournier This you?