BRI

Peptides

What began as a routine check triggered by a persistent odor led to an unsettling discovery: a hidden lab operating inside a California warehouse containing dangerous pathogens including HIV, malaria, COVID-19 and Ebola. latimes.com/california/sto…

A duo of drugs that boosts our glympathic system, which clears waste from our brain, also improves the removal of proteins associated with the onset of Alzheimer's disease #Echobox=1774467810" target="_blank" rel="nofollow noopener">newscientist.com/article/252084…

Chronic diseases now cause 74% of global deaths. A NEJM paper identifies fossil fuels, tobacco, ultra-processed foods, chemicals and alcohol as major corporate-driven health risks. doi.org/hbtt7n medicalxpress.com/news/2026-03-s…

The Narborough bone mill, with a big cast-iron wheel typical of industrial revolution water power, partially restored. It made calcium phosphate fertilizer out of bones from slaughterhouses, whaling, and, it was rumored, from a Hamburg cemetery: norfolkmills.co.uk/Watermills/nar…

Thymosin alpha 1 (Tα1) reduces the mortality of severe COVID-19 by restoration of lymphocytopenia and reversion of exhausted T cells academic.oup.com/cid/article/do… “Tα1 reverses T cell exhaustion and recovers immune reconstitution through promoting thymus output during SARS-CoV-2…”

Life itself underwent revolutions that increased its scale. One of the earliest was when it evolved the ability to break the triply-bonded N2 to create the single-N-containing molecules needed to make all amino acids, and thus all proteins. unenumerated.blogspot.com/2010/10/elemen…

Big old Big History 🧵: biology, the origins of life, farming, disease-killing drinks, bone grinding and bone china, hay, fertilizer, and the Agricultural Revolution:

“Combining current antitumor treatments and senolytics can eliminate senescent cells more effectively and improve treatment outcomes in hematologic malignancies.”

Thymus health is a predictor of lifelong well-being and immunotherapy effectiveness nature.com/articles/d4158…

SS-31 upregulates enzymes required for cardiolipin biosynthesis and remodeling, and restores mitochondrial biogenesis. peptidesciences.com/blog/ss-31-als… SS-31 repairs mitochondrial cristae architecture in aged mice:

Targeted Elimination of Senescent Beta Cells Prevents Type 1 Diabetes 🍪 “Significantly, elimination of senescent beta cells halted immune-mediated beta cell destruction and was sufficient to prevent diabetes.” pubmed.ncbi.nlm.nih.gov/30799288/

Most senescent cells contain uPAR receptors in elevated quantities. By encouraging immune cells to bind with uPAR receptors, it’s plausible that more senescent cells could be eradicated without destroying as many normal cells in the crossfire. Many normal cells contain uPAR, but immune cells won’t automatically kill normal cells — even if they are attracted to them. Immune cells that come in contact with senescent cells are wired to kill them, but oftentimes the meetup never happens. Endogenously, release of SASP-inflammation from senescent cells can attract an army of immune cells (NK cells and T cells) that bring them closer to senescent cells. It’s almost as if SASP-inflammation is a flare that recruits an army of immune cells to eliminate the senescent cell.

In world first - Japan approves ground-breaking stem-cell treatments for Parkinson's and severe heart failure u.afp.com/Su6H

One-of-a-kind microscope reveals living cells in unprecedented detail phys.org/news/2026-03-k…

Meet BioGPT-Large: a specialized AI trained on millions of PubMed articles. It's not just another language model. It's a biomedical expert that can generate and understand complex medical text. This is huge for researchers and developers.

Targeting hippocampal neurogenesis to protect astronauts’ cognition and mood from decline due to space radiation effects 🛸 “mechanistic discoveries of radiation injury on hippocampal neurogenesis… The most promising pro-neurogenic drug, NSI-189, has been developed by Neuralstem (now Seneca Biopharmaceuticals) for the treatment of MDD (Fava et al., 2016a, 2016b)…” pubmed.ncbi.nlm.nih.gov/36336363/

Those Who ‘Age Well’ Show Higher Rates of Hippocampal Neurogenesis Than Typical Older Adults 🧠 medicalxpress.com/news/2026-02-s…

Asked Rosalind to model trastuzumab PK. It downloaded the PDB structure, wrote an R script using mrgsolve, ran a 2-compartment model with real PopPK parameters (Bruno et al. 2005), and gave me Cmax, Ctrough, and a full 24-week PK profile. One prompt. We are coming out with detailed blogs of Rosalind, one capability at a time, very soon.

COVID Perturbs Brain Chemistry and Bleeding, Unlike Flu Viruses 🧠 “Although neither virus was found in brain tissue, mice that had COVID-19 showed signs of persistent brain inflammation weeks later, along with tiny areas of bleeding. Gene expression analysis revealed ongoing inflammatory signaling and disruption of pathways involved in serotonin and dopamine regulation, systems closely tied to mood, cognition and energy levels. These persistent changes were largely absent in influenza-infected animals.” medicalxpress.com/news/2026-02-t…