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(1/7) Very excited to share my first PhD preprint on the interactions of two of my favorite mobile genetic elements: phages and group II introns!
biorxiv.org/content/10.110…
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Liana Merk
63 posts
Liana Merk
@BacteriYay
Harvard Biophysics G3 | Eddy Lab | 🧫🥣🌍🧬 | she/her
Woods Hole, MA Katılım Kasım 2021
309 Takip Edilen211 Takipçiler
Liana Merk retweetledi
Excited to be a part of this team! Check out our work investigating scientific problem solving in LLMs!
Alan Li@alanli2020
1/9 🚀 New paper: Demystifying Scientific Problem-Solving in LLMs — How does reasoning enhancement affect knowledge recall, and do LLMs benefit from external knowledge complimentary to reasoning? Tldr; 📊 SciReas: holistic and efficient evaluation suite for scientific reasoning 🧠 KRUX: a novel framework to study knowledge vs reasoning in LLMs 🔑 Findings: knowledge is a bottleneck; reasoners + in-context knowledge help; long CoT helps knowledge recall/utilization
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Liana Merk retweetledi
Prevalence of Group II Introns in Phage Genomes biorxiv.org/content/10.110… #biorxiv_bioinfo
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(7/7) We’d love to hear your thoughts, and if you are at the RNA conference in San Diego this week, I am presenting this work at P2-353 in the second poster session!
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(6/7) We highlight a few stories: evidence for retroposition into phage-specific loci, unique CapR domains not reported in gpII intron-encoded homing endonucleases, and the presence of a gpII intron in an annotated Inovirus, the first gpII intron noted in a ssDNA organism.
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(1/7) Very excited to share my first PhD preprint on the interactions of two of my favorite mobile genetic elements: phages and group II introns!
biorxiv.org/content/10.110…
English
Liana Merk retweetledi
Get ready to dance, our paper – Phage DisCo: targeted discovery of bacteriophages by co-culture – has been pre-printed! 🪩 This has been a really fun project to work on with @implosian, @baym, @nquinoneso, Kesther and Carmen! biorxiv.org/content/10.110… 1/
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Liana Merk retweetledi
Thrilled to share that I'm starting my own lab at UC Irvine in April 2025 and am recruiting at all levels - please spread the word! My lab will study how microbes interact and evolve in complex communities like the human gut microbiome. kxuelab.com 1/2
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Liana Merk retweetledi
1/8. 𝐧𝐜𝐑𝐍𝐀𝐬 often fly under the radar... but they're vital in bacteria-phage conflicts & beyond. Curious 𝙬𝙝𝙮!? 🤔
Here, we dive into their immune roles, plasticity, and discuss their hidden potential! 🧬🚀
🔗:cell.com/trends/microbi…
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Liana Merk retweetledi
My favourite discovery ever has just come online. Can I please tell you about some seriously wacky molecular biology? The story starts with a reverse transcriptase that SOMEHOW defends bacteria from viruses.
(👇 I recommend sound ON for the video 🎹)
1/
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Liana Merk retweetledi
Super excited to share my postdoc work investigating how mating and parental behaviors evolve using wild species of mice combined with single nucleus RNA-sequencing of the hypothalamus 🐭🧠🧬!
biorxiv.org/content/10.110…
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Liana Merk retweetledi
Thrilled to see the first review article from my lab out in advance @AnnualReviews, helmed by @Celia_Sqe: From Petri Dishes to Patients to Populations:
Scales and Evolutionary Mechanisms Driving Antibiotic Resistance
annualreviews.org/content/journa…
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Liana Merk retweetledi
Woohoo, our paper on the discovery of 65 new phages dependent on conjugative plasmids is published in it's final form today in @NatureComms ! Here follows a thread (1/ ) link.springer.com/article/10.103…
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“It’s never too early to drink spent media”
-@wc_ratcliff when I brought kombucha to 9:30 am lab meeting
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Liana Merk retweetledi
How do bacteria navigate environmental variation in human hosts?
In our newest preprint, we find bacteria can use “permanent” solutions for temporary problems — mutation-mediated phenotypic switching!
See: biorxiv.org/content/10.110…
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Liana Merk retweetledi
Excited to share some new work led by Jimmy Ferrare. How do rapidly adapting pop'ns balance short-term selection for fitness & long-term selection for evolvability? We develop a theory to predict how these indirect selection pressures emerge from competition btw linked mutations
bioRxiv Evobio@biorxiv_evobio
Evolution of Evolvability In Rapidly Adapting Populations biorxiv.org/cgi/content/sh… #biorxiv_evobio
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