Anthony Bain, PhD

@Nyborger_Nybo @DebevecTadej Agree - within changes in flow vs baseline cross-sectional compare different things. My point is to not neglect metabolic changes from CO2 or heat (both potent metabolic modulators).

@BainPhd @DebevecTadej yes - but with lower flow -> increased extraction and in the Paper with CO2/hyperventilation we also see "inverse flow-glucose extraction relationship in resting conditions (within same participant) - my point is that the cross-sectional observations are not "universal"

Brain glucose extraction is fixed at 10% despite twofold variability in resting cerebral blood flow in healthy humans journals.sagepub.com/doi/10.1177/02…

@Nyborger_Nybo @DebevecTadej Could this also be related to changes in metabolic rate? onlinelibrary.wiley.com/doi/10.1111/ap…

@DebevecTadej and here marked change in a-vDiff for GLUCOSE when CBF is manipulated at rest (with CO2/hyperventilation) journals.sagepub.com/doi/pdf/10.103…

@Nyborger_Nybo @DebevecTadej But this is during hyperthermia, which increases metabolism pubmed.ncbi.nlm.nih.gov/31900940/

@DebevecTadej lack of lactate measure + not what we see in same person when flow is "manipulated" - journals.physiology.org/doi/pdf/10.115… (hyperthermia -> CBF down -> glucose extraction up)

We argue a small dose in those habitual users (the majority) is better! Also hate withdrawing…

Caffeine in cerebrovascular research: To withdraw or not to withdraw? - Shepley - Experimental Physiology - Wiley Online Library physoc.onlinelibrary.wiley.com/doi/full/10.11…

@jonathan_smirl @DamianMBaileyEP @ExpPhysiol Excellent idea! Although I suspect he’ll win that one as well (much more efficient swimmer).

@BainPhd @DamianMBaileyEP @ExpPhysiol Maybe merge the two and do underwater horizontal distance instead of depth?

Thanks @DamianMBaileyEP for the opportunity to write this one - my ‘failed’ attempt at freediving @ExpPhysiol physoc.onlinelibrary.wiley.com/doi/full/10.11…

@jonathan_smirl @DamianMBaileyEP @ExpPhysiol Ha - already in discussion. Taking recommendations

@BainPhd @DamianMBaileyEP @ExpPhysiol Very informative and interesting narrative on the "Intro to Freediving". Anyone interested in integrative physiology should give this a read! The next question seems to be, what is the next feat of strength to break the 1:1 tie?

@ollie_jay13 @HeatHealth_USYD @IntegrPhysLab @NEJM @GeorgiaKatec @LilyHospers @DrYorgiMavros @AmyHarwood91 @syd_health @Sydney_Uni Congrats, Ollie and Dan! What a great contribution.

Our paper from @HeatHealth_USYD and @IntegrPhysLab out now @NEJM @GeorgiaKatec @LilyHospers @DrYorgiMavros @AmyHarwood91 @syd_health @Sydney_Uni Simple Strategies to Reduce Cardiac Strain in Older Adults in Extreme Heat | New England Journal of Medicine nejm.org/doi/full/10.10…

@RyanLeoHoiland @_CARNet__ @J_C_MD_PhD @JJ_Walsh16 @balkhaz Hoping one or two will go (unfortunately I can’t). Line up looks stellar

@_CARNet__ @J_C_MD_PhD @JJ_Walsh16 @balkhaz @BainPhd. You or any of your students coming to CARNet? Debate should be good fun!

CARNet 2024 - Oct 29 to 31, 2024 Debate between Prof Olaf Paulson and @J_C_MD_PhD ! DISCUSSION: The classic autoregulation curve (Lassen) under debate Register today ! event.fourwaves.com/carnet2024/pag…

@Sandy_REACHLab Tymko summer world tour 2024 - great to see it!

Always wonderful to meet like-minded colleagues with interests in vascular health. #cerebrovascular #MichaelTymko from U of Guelph stopped thru KC to tour the #REACHLab and talk science. A few great #Ainslie stories were shared!!

🔷Our department is doing groundbreaking research into the use of low-light lasers as a treatment for Parkinson's disease. Read more here: bit.ly/49aAzDv #uwindsor #Windsor #yqg #parkinson #parkinsonsdisease #research #kinesiology #laser

This is fantastic. @sweatscience with an absolute killer opener...and the article follows suit on tearing apart our obsession with supplements and silver bullets. A must-read: outsideonline.com/health/trainin…

🎓EDITOR'S CHOICE🎓 This study by @BainPhd (@uwinkinesiology) et. al. shows that the hypocapnia protects the brain from elevated penetration by microvesicles, which otherwise might cause cerebral inflammation! 📜buff.ly/46XMkuU

@KhushaliParikh_ @uwinkinesiology @bshepley2

Cerebral uptake of microvesicles occurs in normocapnic but not hypocapnic passive hyperthermia in young healthy male adults - Parikh - The Journal of Physiology - Wiley Online Library. A potential ‘protective role’ for heat-induced hyperventilation? physoc.onlinelibrary.wiley.com/doi/10.1113/JP…

@CelticsU13A @aclevel24 Congrats Isaac!!

Here’s Isaac. Great game, #80!

We are currently engaged in a large collaborative work spanning various disciplines to drive innovation in human breathing sensing @SimonRondeau @BainPhd

@Mypster2 @RyanLeoHoiland @HlthResearchBC @VGHFdn @UBCDoM Well deserved!! Congrats Ryan