Bartek Lab

We identified a ribosome biogenesis-associated gene signature with prognostic/predictive value in Acute Myeloid Leukaemia. Many thanks to all authors and our funding agencies! @Vetenskapsradet, @cancer_dk, @Cancerfonden, @cancerforskning haematologica.org/haematologica/…

S hlubokým zklamáním upozorňuji na rozpočtové opatření schválené vládou dne 19. 11. (usnesení vlády č. 914/2025), které přesouvá z oblasti vědy a výzkumu více než 500 mil. Kč (dohromady u TA ČR, GA ČR, AV ČR a AZV/MZ) a 1 mld. Kč v rámci MŠMT (nevím z jakých zdrojů) do rozpočtu MŠMT, pravděpodobně na pokrytí nákladů na nepedagogické pracovníky ve školách, kde chybí asi 3 mld. Kč. Tyto prostředky budou ve vědě a výzkumu velmi bolestně chybět a to i s ohledem na 30% inflaci, která v rozpočtu nebyla kompenzovaná. Pokračuje tak reálný pokles financování vědy, výzkumu a inovací v poměru k HDP. Je to další rána vědě a inovacím v České republice, která snad nejvíce oborově postihne zdravotnický výzkum a medicínu.

To all colleagues - we have a nearly brand new Evident ScanR microscope for sale. Less than 100 hours of use, 60% of original price. A real bargain for the aficionados. Please PM for details

The new review “The need for speed: drivers and consequences of accelerated replication forks” summarizes current understanding of how replication fork speed is regulated and why it matters. Read here: nature.com/articles/s4200…

Encouraging to see how both the science and the people have advanced. Our 2018 study showed that PARP inhibitors accelerate replication fork progression (Maya-Mendoza et al., Nature), a finding later followed up by several other labs. nature.com/articles/s4200…

Our first group method paper is out in @STARProtocols from the @bmbSDU @NATsdu, presenting a robust imaging approach to monitor de novo RNA synthesis at DNA DSBs! Huge shout-out to all co-athors and to our collaborators from the @Bartek_Lab sciencedirect.com/science/articl…

PARP1 auto-modification promotes faithful Okazaki fragment processing and limits replication fork speed dlvr.it/TNSZx9

Sharing our latest work @UZH_en tracking DNA damage inheritance by Live+QIBC nature.com/articles/s4158…. Huge congrats to @APanagopoulos_, M. Stout and all co-authors for this tour de force! Beautifully summarized by @S_J_Aitken and E. Reilly @NatureNV nature.com/articles/d4158….

🧬 Zbývá už jen poslední měsíc na přihlášení na PhD pozici zaměřenou na výzkum replikace DNA. Přidej se k našemu týmu a podílej se na špičkovém biomedicínském výzkumu! 📍Ústav Molekulární a Translační Medicíny, UPOL Olomouc 📅 Deadline: 15.5.2025 researchjobs.cz/job/phd-pozice…

📢 For all DNA fiber enthusiasts! 🟥🟩 We are thrilled to announce the release of our long-awaited AI-based workflow for the automated and quantitative analysis of DNA fibers. It's an exciting step forward—check it out on bioRxiv! lnkd.in/dQWUPtsP

Our new preprint is now on bioRxiv! 📄 We introduce qAID, an AI-based workflow for automated analysis of DNA replication dynamics. Glad to have contributed a small part to this study.

Působíte vědecky v Dánsku? 🇩🇰 Přijďte se potkat! 💫 Další ze série lokálních setkání proběhne 25. dubna na Velvyslanectví ČR v Kodani ve spolupráci s @czexpats 🤝 Těšit se můžete na keynote přednášku kognitivní neurovědkyně @HanaMalaRytter, sérii krátkých flash talků a samozřejmě spoustu networkingu 🗣️ 💬 Registrace je otevřená do 21. dubna 👉 czexpats.org/udalost/setkan… Budeme se moc těšit! 🙌

Looking for a PhD in cutting - edge cancer research? Join DNA replication dynamics group at @IMTM_Olomouc @NUVR_CZ @UPOL to study PARP inhibitors - key cancer drugs - and their impact on DNA replication. The fight against cancer starts in the lab! #PhDposition #CancerResearch

We managed to get one last paper rdcu.be/d5gAe over the line before the new year🥂! We are pleased to share the first Nature Cell Biology paper from our lab functionally validating the role of a frequently occurring lung cancer driver, FAT1 in cancer evolution. 🧵1/13

📢 Happy to share our bioRxiv preprint on how CRL4-DCAF12 regulates the cellular level of MCMBP, a chaperone of nascent MCM2-7 complexes, to ensure error-free genome duplication. The full story can be found here: lnkd.in/eCjVNQks

🚀 #Postdoc Opportunity! 🚀 Join my lab @UniSouthDenmark in the Translational Cancer Hub initiative. Dive into cellular #senescence & its impact on cancer progression & therapy resistance! Apply here 👇 nature.com/naturecareers/…

Important breakthrough! Our scientists have identified a new molecular target for cancer therapy, focusing on hereditary breast & ovarian cancers. Published in @NatureComms, their findings on DNA replication could lead to more effective treatments.💊imtm.cz/news/scientist…

We are very excited to share our manuscript "Hyper-recombination in ribosomal DNA is driven by long-range resection-independent RAD51 accumulation" now online in Nature Communications :-) nature.com/articles/s4146…

Thrilled to announce our latest bioinformatic study in @NatureComms! If your interests are genome maintenance mechanisms in mitosis or DNA repair check out this rich resource of new genome maintenance candidates doi.org/10.1038/s41467… #dnarepair #replication #AlphaFold #Cancer

Have you ever wondered which DNA polymerases are responsible for accelerated replication forks?