Basit Ali Chaudhry

Investigation of the rimegepant effect on cerebral and extracerebral arteries during migraine attacks: a longitudinal magnetic resonance angiography study academic.oup.com/braincomms/art…

Large 3T MRI study finds no subcortical volume differences in #migraine vs controls or across migraine subtypes. ➡️ Structural size ≠ migraine biomarker Full article: …adachejournal.onlinelibrary.wiley.com/share/HVB3TG2H… @BasitAliChaudh4 @RuneHackert @h_ashina @MessoudAshina @drfa_CPH et al

New in Cephalalgia! The current study demonstrates altered brain structure in persistent post-traumatic headache using MRI. Changes in pain-processing brain regions similar to migraine suggest shared neurobiological mechanisms. journals.sagepub.com/doi/10.1177/03… #migraine #headache #brain #pain #neurology #neuroscience

In today's plenary session, 'Unveiling PACAP's role in migraine: Evidence from human provocation studies,' Professor Messoud Ashina delivered an insightful overview of the role of PACAP in migraine pathophysiology and future treatment.

Persistent posttraumatic headache shows cortical enlargement in pain-processing regions on 3T MRI vs healthy controls. Similar profile to migraine. Shared mechanisms may sustain chronic pain. ⁦@lundbeckfonden⁩ ⁦@ihs_official⁩ journals.sagepub.com/doi/10.1177/03…

🧠 Highly Interesting Review in Cephalalgia! “Cortical thickness studies in migraine: Current evidence and future directions” 📅 Published June 6, 2025 | 🔓 Open Access Cortical thickness is emerging as a key marker of migraine-related brain changes. This comprehensive review synthesizes current evidence from surface-based and voxel-based morphometry studies, highlighting: 🔹 Thickening in pain-processing regions (somatosensory cortex, insula, anterior cingulate) – possibly reflecting hyperexcitability. 🔹 Thinning in regions like the orbitofrontal and visual cortices – suggesting cortical integrity loss. 🔹 Differences between episodic vs chronic migraine, and preliminary signs of reversibility with CGRP-mAbs and botulinum toxin A in responders. 📌 The review underscores the potential of cortical thickness as a biomarker—but also the pressing need for standardized protocols and longitudinal data. 🔗 Read the full article: doi.org/10.1177/033310… #Migraine #Neuroimaging #CorticalThickness #MRI #Cephalalgia #HeadacheResearch #Neurology #CGRP #Botox

🔬 New study finds signs of cortical inflammation in migraine using quantitative MRI! 📊 Higher T2 values in the occipital cortex suggest edema or immune activation in those with migraine aura. 🧠💥 Read more here: onlinelibrary.wiley.com/doi/epdf/10.10…

Thursday News 🗞️ Excited to announce our latest paper in @bmj_latest: a network meta-analysis comparing 17 acute #migraine meds 💊. Eletriptan, Rizatriptan, Sumatriptan, & Zolmitriptan outshine newer #CGRP-targeted treatments 🧠bmj.com/content/386/bm… bmj.com/content/386/bm…

🧠The signaling molecule PACAP plays a key role in triggering migraine attacks. Discover how PACAP could reshape migraine treatment and bring relief to those in need 💡👇⁦@hmru_cph⁩ ⁦@ihs_official⁩ ⁦@EANeurology⁩ ⁦@EHF_Official⁩ nature.com/articles/s4158…

Al-Khazali et al. show that individuals with migraine experience more problems related to neck pain compared to those with tension-type headache and healthy individuals without headache. journals.sagepub.com/doi/10.1177/03… #headache #migraine @HaidarAlKhazal2 @SaitAshina @HenrikSchytz

New migraine treatment targeting PACAP shows promise! Lu AG09222 reduces migraine days for those unresponsive to other therapies. A potential game-changer in migraine care! #Migraine #Neurology #PACAP 👇 rb.gy/q0h88y

🚨 New hope for people with migraine! A Phase 2 study shows that a monoclonal antibody against PACAP reduces migraine days. 🌟⁦⁦@Rigshospitalet⁩ ⁦⁦⁦@ihs_official⁩ ⁦@lundbeckfonden⁩ ⁦@hmru_cph⁩ ⁦@EHF_Official⁩ nejm.org/doi/full/10.10…

Exciting news! In 2009, our lab was the first to show that the signaling molecule #PACAP can trigger #migraine attacks 🧠 Now, a phase 2 trial confirms that blocking PACAP can prevent them! A big step forward in migraine #research 🌟 Read more: nejm.org/doi/full/10.10…

Possible pathophysiological mechanisms of medication overuse #headache involve potential genetic factors, peripheral mechanisms and central mechanisms, including descending pain modulation. go.nature.com/3XZtJen

🔬 New research paper finds hypersensitivity to BKCa channel opening in people with post-traumatic headache🧠 Targeting BKCa channels might open new avenues for drug discovery 💊@h_ashina @HaidarAlKhazal2 @BasitAliChaudh4 Read more here: …alofheadacheandpain.biomedcentral.com/articles/10.11…

MRI of the brain is necessary to exclude symptomatic causes of trigeminal neuralgia go.nature.com/4aEbVe9

#Trigeminal #neuralgia is a facial pain disorder characterized by intense and paroxysmal pain that profoundly affects quality of life go.nature.com/4bGTiI2

Now in #PAIN: “Induction of cluster headache after opening of adenosine triphosphate-sensitive potassium channels: a randomized clinical trial” by @HaidarAlKhazal2 et al. bit.ly/3K0UtWd

Localization of pain in trigeminal neuralgia based on dermatomes innervated by the trigeminal nerve's sensory branches (V1, V2, V3) and its laterality, reported in published literature #trigeminal #pain #dermatome #neuralgia

Trigeminal Neuralgia is a severe facial pain disorder causing intense, sudden pain. It affects quality of life and requires a multifaceted treatment approach #TrigeminalNeuralgia #Pain #Neurology #Neurosurgery 👇