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Michael Baym
37.5K posts
Michael Baym
@baym
Microbiology, evolution, antibiotic resistance, applied math, molecular biotech. Associate Professor @HarvardMed. Basic research is the engine of progress
A talking head on a screen Katılım Temmuz 2008
1.6K Takip Edilen22.5K Takipçiler
Michael Baym retweetledi
Regular exercise lowers all-cause mortality ~30%. Move daily.
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Michael Baym retweetledi
I also feel like there is a weird valley these days. If you attempt to show something in a shallow manner, somehow the burden of proof seems to be lowered to match. If you aim for depth, ironically, you run into more problems because it engages people's brains again. Hmm.
Michael Baym@baym
What I see a lot of is people so desperate to claim that they’re the one who made some big advance everyone knows is kind of inevitable that they don’t really do it but claim victory, and so when someone actually does it right and for real it’s treated as an also-ran validation
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@Hersh_Desai And yet somehow I remember being laughed out of the room by Great Futurists when I brought up this prospect last time we met
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@FinnMurphy12 Data centers are going to be much harder to build inside the US starting in 2027
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The politics around data centres is going to get really gnarly in the coming 24 months & almost no one in tech has a positive populist story on their benefit.
‘Oh wow increase my energy bill AND take my job? Can they also ruin my view?’
‘But progress’ is not winning messaging.
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The same way Urbana or Geneva are the birthplaces of the web, but y’all aren’t ready for that conversation
NIMI VASHI (bio/acc to infinity & beyond)@nimivashi15
When you take a cab from the SFO airport in Millbrae to SF, you cross South San Francisco- the birthplace of Biotech. You see Mammoth Biosciences (can’t miss this one), AstraZeneca, Merck, Sutro Biopharma all one after the other. The first time I drove through, I knew I had arrived at my destination in life.
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Which also asks how much we should really be lionizing “we all knew somebody was going to do it but who?” papers
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What I see a lot of is people so desperate to claim that they’re the one who made some big advance everyone knows is kind of inevitable that they don’t really do it but claim victory, and so when someone actually does it right and for real it’s treated as an also-ran validation
Anshul Kundaje@anshulkundaje
Honestly feel kinda sad to see so many young scientists adopting and idolizing ultra hype culture. I think people don't really understand the medium and long term consequences to their own credibility and that of science as a whole.
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Michael Baym retweetledi
And exactly this is happening in phage biology.
Minus the retracted papers… because no one is checking
Sequence your phages! Not just once. Have a system. It’s not expensive.
Every time I sequence a bunch of phages I find stowaways.
Ming "Tommy" Tang@tangming2005
1/ A researcher spent 2 years studying liver cancer biology. Published 3 papers. Then discovered the "liver cancer" cell line was actually HeLa -- a cervical cancer line that contaminated their stock decades ago. Those papers? Retracted.
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And for those of you stoked about FROs and industry research labs and whatnot, they aren’t the answer either.
They’re great for large applied engineering projects, but fundamental curiosity-driven research is still the best way our civilization knows to find truly new knowledge
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This argument, that what’s ultimately right and better may not appear to be the best solution now, is the best rebuttal I’ve heard to the current fervor for translational and applied research over basic science
Dwarkesh Patel@dwarkesh_sp
When Copernicus proposed heliocentrism in 1543, it was actually less accurate than Ptolemy's geocentric model - a system refined over 1,400 years with epicycles precisely tuned to match observed planetary positions. It took another 70 years before Kepler, working from Tycho Brahe's unprecedentedly precise observations, replaced Copernicus’s circles with ellipses - finally making heliocentrism empirically superior. Terence Tao's point is that science needs a high temperature setting. If we only fund and follow what's most state of the art today, we kill the ideas that might need decades of work to surpass some overall plateau.
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Sadly, no fundraising medical school deans are going to see this and really think about what it means
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Semaglutide came off patent
WyattzWorld@WyattzWorId
Did something come out today? Why the fuck are people wrapped around Best Buy at 10 am
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Michael Baym retweetledi
Happy to announce that our paper on orphan genes in bacteria dropped in PNAS yesterday!
This is a problem I've been thinking about since the start of my PhD. Grateful for this journey, as well as All The Friends I Made Along the Way.
Also, Eid Mubarak to those who celebrate!
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OK, I don't like the term plasmidome, but otherwise this looks pretty cool / interesting:
nature.com/articles/s4146…
A global soil plasmidome resource unveils functional and ecological roles of plasmids in soil microbiomes
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Michael Baym retweetledi
This spring, numerous European scientists have declined invitations to scientific conferences in the US, explicitly citing the current political climate as their reason for declining.
This is at once understandable and stunning.
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As a kid, watching Walker, Texas Ranger taught me that many problems in life can be solved by a well-timed roundhouse kick, a lesson that has served me well in academia
TMZ@TMZ
🕊️ Chuck Norris has died at 86. tmz.me/N3EVxQe
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Michael Baym retweetledi
Postdoc position now open in my lab at New England Biolabs. Focus is on exploring phage defence systems through biochem and structural biology. @NEBiolabs provides an academic research environment with the freedom of industry. Please take a look! 🤓🧫🧬 tinyurl.com/49phcyh6
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