Dr. Rebecca Gladstone

Now published! 'Identification of transporter-dependent capsular loci associated with the invasive potential of Escherichia coli' nature.com/articles/s4156… insights below.....

Data from invasive neonatal infections showed a major difference in the proportion of transporter-dependent K-loci between Europe and LMICs, indicating different vaccine design requirements.

We created a database compatible with Kaptive3 of 90 distinct capsule (K) loci; 66% represented novel K-loci that did not correspond to the known phenotypic K-antigens. Give it a whirl, and get in touch to have novel K-loci added to the DB github.com/rgladstone/EC-…

Now published! 'Identification of transporter-dependent capsular loci associated with the invasive potential of Escherichia coli' nature.com/articles/s4156… insights below.....

And special thanks to Handal and Kaspersen et al. (doi.org/10.1093/jac/...) for sharing their AST data to serve as a UTI validation set.

It's largely infeasible for national genomic surveillance at the scale AST data is available (here 24,866 BSI and 28,639 UTI E. coli, 2006–2021), but combining existing 3254 BSI genomes and AST data allowed us to estimate the importance of a notorious MDR clone in Norwegian UTIs.

"Machine learning-based lineage prediction from antimicrobial susceptibility testing phenotypes for Escherichia coli sequence type 131 clade C surveillance across infection types" The MDR ST131-C is pervasive in UTIs, underlying BSI trends doi.org/10.1099/mgen... @MicrobioSoc

How invasive are different E .coli capsules and how many are there? Find out here and use the group 2 and 3 database to type your own! medrxiv.org/cgi/content/sh…

Unsung hero who processed tens and thousands DNA 🧬 extraction for the #GPS_project @sangerinstitute Left to Right: Sally Kay, Kirsty Ambridge, Terry Judah, Annie Fletcher, Nicole Sevilleno, James Groom and Divenita Govender #pneumococci #DNA #Genome

What's cool about this is the fact that Norway has been sequencing all IPD routinely since 2018! Coupled with >20 years of pre-PCV data we can really see the fantastic impact of vaccination, and the role of those pesky NVTs aready in Norway just waiting in the sidelines

So seriously, in grad school a therapist gave me some solid advice: If you try to bring work on vacation you’ll succeed at neither. You have to give yourself permission to relax knowing the work will still be there for you when you return

I’m excited to share our work Estimating between-country migration in pneumococcal populations academic.oup.com/g3journal/arti… out now in G3 @GeneticsGSA 1/9

✨New Opportunity! ✨ Calling all GPS partners - we're recruiting an early career postdoc for a placement here in Cambridge! Find out more and apply here by the 31st of July! ⬇️ forms.gle/UcT1WTZwCR54vj…

💥 "GET OFF THE ROAD, BITCH!" 9/10 women cycling in London face abuse says new LCC survey. CW: swearing, abuse descriptions Sign the #FreedomToRide petition & share to add your voice >> action.lcc.org.uk/safe-cycling-f… Full report: lcc.org.uk/freedom

Come and work with us on a range of very excited and important projects! We are using genomics to better understand clinical infections and AMR!

Teamwork makes the dream work! AK Pöntinen*, RA Gladstone*, @henri_pesonen , M Pesonen, F Cléon, BJ Parcell, T Kallonen, GS Simonsen, NJ Croucher, @alanmcn1 @JulianParkhill @Paal_Johnsen @Orjan_Samuelsen & J Corander!

We also used E.coli colonisation frequencies in a UK neonatal cohort to compare success in disease against colonisation. We confirmed C1 and C2 are found considerably more often than expected in disease. Clades A and B are found more often in carriage.

It's out! Further exploring different ST131 clade success in UK/Norway due to abx use! Modulation of multidrug-resistant clone success in E. coli populations: a longitudinal, multi-country, genomic and antibiotic usage cohort study - The Lancet Microbe thelancet.com/journals/lanmi…