Massive effort from @duttmri and thanks to @UniMelbCMR @MattWattUnimelb @garrondodd @GordonSLynch @WEHI_research and many others!
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Benjamin Parker
72 posts
Benjamin Parker
@BenParkerLab
Research group of @Ben_Leo_Parker @UniMelb as we lost access to previous account. We love metabolic proteomics and signal transduction.
Melbourne, Victoria Katılım Mart 2024
199 Takip Edilen160 Takipçiler
Our #phosphoproteomics analysis of insulin signaling in bone uncovered a new mechanism of transcriptional activation via S6K phosphorylation of AFF4. It appears to play a role in regulating the expression of genes in ageing and insulin resistance. nature.com/articles/s4146…
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Thanks for all the support!
Centre for Muscle Research@UniMelbCMR
Congrats to the CMR's @duttmri, @Ben_Leo_Parker and Team for their new Nature Comms paper "Phosphoproteomics of aged insulin-resistant bone identifies P70S6K phosphorylation of AFF4 as a gene-specific transcriptional regulator" @UniMelbMDHS @UniMelb nature.com/articles/s4146…
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Protein:protein interactions are dynamic so how do we quantify and discover changes in native tissues? Our new study uses qXL-MS and PCP-MS to study dynamic remodeling of interactions following skeletal muscle insulin resistance. biorxiv.org/content/10.648… #myotwitter #proteomics
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An amazing opportunity with such a cool team!
A/Prof Garron Dodd@garrondodd
🚨 Join Our Team! 🚨 We’re on the hunt for a brilliant postdoctoral researcher with a passion for neuroscience or metabolic disease. This is your chance to work at the intersection of academia & industry, driving innovation in obesity & T2D research. 🌟 jobs.unimelb.edu.au/caw/en/job/919…
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Thanks for the leadership @MattWattUnimelb! Couldn’t have done it without you.
Matthew Watt@MattWattUnimelb
Thrilled that the metabolism theme in Dept of Anatomy & Physiology were awarded NHMRC and ARC grants in #obesity #MASLD, #fibrosis and #aging. Go @garrondodd @Ben_Leo_Parker @MagdaMontg64866 @MattWattUnimelb 🎉💯🙂 @UniMelbMDHS
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@UniMelbCMR @JustinHardeePhD @UF @UFMyology @UniMelbMDHS @UniMelb You’ll be missed @JustinHardeePhD but good luck in the new position!
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After 7 years (2018-2024) in the CMR, we farewell @JustinHardeePhD.
We congratulate him on his many achievements with us, including prestigious fellowships and awards.
We wish him much luck and success as an Assistant Professor at @UF.
@UFMyology #Myotwitter @UnimelbMDHS @UniMelb
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Check out our latest: Variable #glucagon metabolic actions in diverse mouse models of #obesity and type 2 #diabetes
sciencedirect.com/science/articl…
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@MattWattUnimelb @UniMelbMDHS It was the best retreat I’ve ever attended!
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Just spent two days at the Department of Anatomy and Physiology retreat. Inspired by the collegiality, openness and our future together. @UniMelbMDHS #nogolf!
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@ucdmrt Sorry, meant to say Cysteine not Lysine! That makes complete sense.
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@BenParkerLab It is because it contains a cysteine in the catalytic pocket that coordinates the enzymatic hydrolysis. Unlike LysC and Trypsin which are serine class proteases. So if the cysteine gets alkylated the activities is gone as well.
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We are launching our latest product, Arg-C Zero!
This is a really cool protease and it delivers ultimate efficiency, basically close to 0% missed cleavages at arginine residues (hence the "Zero"... get it ? 😅 )
Feel free to reach out for any Q's :)
#Proteomics #TeamMassSpec
KPL ApS@KPL_ApS
🚀Introducing Arg-C Zero (KPL0146)🧬 Next-gen proteomic enzyme with close to 0% missed cleavages at Arginine residues! 🔬100% Arginine cleavage + ultimate specificity = next-level protein analysis magic ✨ 🧬 Details: kplbio.com/product/arg-c/ #Proteomics #TeamMassSpec #proteins
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Benjamin Parker retweetledi
Abstract submissions are closing in a few weeks! Register now for the free WEHI Proteomics Symposium co-hosted by PMV.
eventbrite.com.au/e/proteomics-s…
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@funtoshs @ItsBiniR @UCDProteomics @ProteomicsNews Ah, I see. Maybe you could simply dimethylate a lysate and use this to preclear? Simple protocol here (obviously just using ‘light’ for your application) nature.com/articles/nprot…
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@BenParkerLab @ItsBiniR @UCDProteomics @ProteomicsNews Yes on similar lines, thanks. To coat the beads to prevent non-specific binding rather than interact with a tagged bait.
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Is there any report in literature on passivating beads using a Lys/Arg-free protein for pull-down or IP-MS? #TeamMassSpec
@ItsBiniR
@UCDProteomics
@ProteomicsNews
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@brettcollins100 @igordownunder @arc_gov_au More than crazy. A complete disregard of academics in general. Grant outcomes on Xmas eve, shifting dates, changing rules, modifying eligibility, cutting sections or adding new ones to make the most complicated applications in the world, the list goes on….It’s an absolute mess!
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@igordownunder @arc_gov_au Yes it's true. And ARC is much better at this than NHMRC. But it is still completely crazy that a new round of EOIs are open before the results of the previous round are even known.
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Another year where Oz researchers depend on an anonymous Twitter account (no offence ARC tracker!) rather than clear and sensible messages from the funding agencies!
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Interested in #skeletalmuscle in #ALS #MND? Then this one is for you! Check out this thread by @BenParkerLab re some really cool work and what we found. A huge thank you to people with ALS/MND and healthy donors who contributed their samples! @UQ_News @AIBNatUQ @UQMedicine
Benjamin Parker@BenParkerLab
Check out our new #proteomic method to site-specifically quantify UFMylation! We applied the approach to look at human skeletal muscle biopsies from #ALS. A great collaboration with @CellSignal and many others... A little summary below... biorxiv.org/content/10.110…
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A big thanks to @UniMelbMDHS and @CellSignal for supporting this research, and several collaborators @UniMelbCMR @JamesMc2327 @CraigAGoodman1 @OchDr @NgoShyuan and many others!
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Why do we care? Because we have previously shown that UFC1 levels are negatively correlated with lean mass in various mouse strains, and knockdown of UFC1/UFMylation can increase muscle function. Maybe myosin UFMylation is a key link?
doi.org/10.7554/eLife.…
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UFMylation is a ubiquitin like modification of UFM1 applied to substrate lysine residues. <15 substrates have been identified (a nice summary: doi.org/10.1016/j.molc…). RPL26 has been most extensively characterised and suggested to be the major substrate: doi.org/10.1073/pnas.1…
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