Bence Daniel

341 posts

Bence Daniel

Bence Daniel

@BenceDaniel2

Principal Scientist @genentech, Epigenetics and Chromatin Biology.

Katılım Ekim 2018
323 Takip Edilen291 Takipçiler
Bence Daniel
Bence Daniel@BenceDaniel2·
Further studies are needed to better understand this mechanism and how widespread it is among cancer types and treatments.
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Bence Daniel
Bence Daniel@BenceDaniel2·
We introduce the "Promoter-switch" concept as an adaptation mechanism in cancer cells when selective pressure targets TEAD/YAP-bound distal elements, shifting reliance to promoter-centric gene regulation.
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Bence Daniel
Bence Daniel@BenceDaniel2·
Exciting news, first preprint from my group @Genentech, led by Vasumathi Kameswaran. We studied TEAD/YAP-addicted mesothelioma cells, and how they resist a pan-TEAD inhibitor. They revert to an old-school way of gene regulation…promoters: biorxiv.org/content/10.110…
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Cartography Biosciences
Cartography Biosciences@CartographyBio·
On #IDWGS, we celebrate women transforming the way we tackle global challenges. From breaking stereotypes to mentoring the next generation, their contributions are shaping the future. We're proud to highlight the stories & wisdom of the #womeninscience at Cartography.
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Caleb Lareau
Caleb Lareau@CalebLareau·
PERFF-seq is out today in @NatureGenet! Our recent thread summarizes why we are excited about the prospects of programmable nucleic acid cytometry for studying rare cell states. nature.com/articles/s4158…
Caleb Lareau@CalebLareau

What a PERFFect day to share our new preprint! With @tsion_abay #BobStickels @MerilTakizawa @ChaligneRonan and @Satpathology, we introduce PERFF-seq, a new experimental approach to studying rare cells with scRNA-seq via transcript-specific enrichment. biorxiv.org/content/10.110… 1/n

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Howard Chang
Howard Chang@HowardYChang·
I am excited to join storied biotech pioneer @Amgen as Chief Scientific Officer and Head of Research. I look forward to partnering with my new colleagues to deepen understanding of biology and develop solutions to the most pressing medical challenges tinyurl.com/5n86sku5
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King L Hung
King L Hung@kinglhung·
Cancer cells often harbor oncogenes outside chromosomes on extrachromosomal DNA (ecDNA), which is unevenly inherited by dividing cells. Today we report in @Nature that collectives of ecDNAs are inherited together by dividing cancer cells. 1/ nature.com/articles/s4158…
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Bence Daniel
Bence Daniel@BenceDaniel2·
wow, an amazing synthetic biology approach, congrats to all involved!
Ansu Satpathy@Satpathology

Happy to share our new work describing DESynR genes! The evolution of new human protein-coding genes relies on repurposing protein domains from ancestral genes, rather than de novo sequence creation. New genes evolved from old parts, and while we have methods that enable high-throughput generation and screening of base-pair level sequence evolution (mutagenesis, directed evolution, CRISPR, etc), we lack similar scalable technologies for domain-level evolution. We developed a high-throughput combinatorial molecular assembly method to generate thousands of barcoded novel genes from the domain building blocks of natural genes, termed DESynR (Domain Engineered via Synthesis and Recombination) genes.

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@genentech @InflammatoryDC @NatureGenet @Amgen @kinglhung @Nature @SagerGosai @elonmusk