Philippe Bertolino

What is a PhD? Open Access embopress.org/doi/full/10.10… #PhD #PhDlife #academics #AcademicChatter #AcademicTwitter #Postdocs #Research #Science

#Senescence #SpatialTranscriptomics Skin Wound Healing P21-high cell clearance⏫ full-thickness skin wound healing🐭(till D12) ⏬Dermal fibroblast ⏬Collagen deposit #Xenium p21-CreERT2::tdT::DTA🐭 p21-high (tdT+) cells are induced & constitute 7% (mainly fibroblasts #EndothelialCell M1Mφ granulocyte/lymphoid cell) of all wounded skin cells vs p16-hi cells▶️only 0.5% cells p21-hi cells are all enriched in transcripts of PDGFA (similar to previously reported p16-hi cells in wounded skin) MMPs TGFb1/3 MCP1 MIP2 +⏫#DNADamage ⏫1.7-fold cell size vs p16-hi cells have a distinct transcript profile Any impact of p21 cell clearance on #HairFollicle regeneration?😆 @MingXuUCHC @NatureAging 2024 nature.com/articles/s4358… x.com/NatureAging/st…

from bench to bedside to restaurant ..... @HCL_research @crcl @Bertolino_Lab #Pituitary translational research group with our guest @elisalamback from @gadelha_monica 's Lab #EmmanuelJouanneau our pituitary neurosurgeon expert is missing (resting)

🚨 Rappel ! En attendant la remise des prix, nous vous rappelons que vous pouvez proposer vos idées d'acronyme et vous inscrire pour le nouveau groupe jeunes en endocrinologie. Scannez les QR codes sur l'affiche ⬇

"Occasionally, you work with people that you cannot, in all honesty, recommend to move on to the next stage of their research career. How do I tell someone that I can't write them a strong letter of recommendation?" go.nature.com/3Yb8uY5

Another excellent #ECE2024 @ESEndocrinology meeting Both our clinical @CRMR_HypoLyon @HCL_research and research #pituitary departments @crcl @Bertolino_Lab are greatly represented

We are now recruiting students to join the Master 2 Cancer Bioengineering in Lyon. For biologists or physicians wishing to move towards interdisciplinarity. tinyurl.com/4mpxe57a Registrations now open : ecandidat.univ-lyon1.fr Do not hesitate to contact me for more info.

Excited to be part of this excellent @EYEScientists @ESEndocrinology initiative with @Bertolino_Lab waiting for #pituitary lovers !!

We are currently looking for a PhD candidate to join the team. Details are bellow : doctorat.campusfrance.org/CF202434149

New content online: Pituitary stem cells: past, present and future perspectives dlvr.it/T0BG3c

GitHub - omnideconv/spacedeconv: A unified interface to spatial transcriptomics deconvolution tools github.com/omnideconv/spa…

Our DARLIN paper is out. We hope that this model really enables and facilitates single cell lineage tracing experiments in the mouse. Thanks specially to @Li_Li_666 and @ShouwenW. More exciting uses of the technology coming out soon... cell.com/cell/fulltext/…

Excellent com by Marie CHANAL from @Bertolino_Lab on new mice model of #pituitary tumors #SFE2023

Long-read whole-genome analysis of human single cells | Nature Communications nature.com/articles/s4146…

I was wondering if sc3D was able to register and display the crazy data from doi.org/10.1016/j.cell…. Here is the result with some Hox genes🤓 (showing downsampled data). sc3D➡️github.com/GuignardLab/sc… ➡️@AbhiSampKumar, @adrianobolondi, @Luyi_T et al.: nature.com/articles/s4158…

When you tell a bioinformatician that they can now run wetlab experiments on their own

@FannyChasseloup @the_hormone_doc @CERMEP @crcl @GeraldRaverot No as you know… it took us quite some time to find the good experimental design. No need to mention that your work was inspiring and motivating 🙏

@Bertolino_Lab @the_hormone_doc @CERMEP @crcl @GeraldRaverot I love it 😻 !!! Was it easy to target the mouse pituitary ?!

Building preclinical models at @cermep and @crcl…. Super excited to image the longitudinal progression of tumour cells we grafted in mouse pituitaries @GeraldRaverot et @Bertolino_Lab , #pituitary, #MRI

Today I have published a guide that introduces some of the key concepts of napari - a multi-dimensional image viewer for Python. Thanks to @martinjones78 and @haesleinhuepf for their helpful feedback. @matous.elphick/napari-a-multi-dimensional-image-viewer-for-python-1522b3e84c11" target="_blank" rel="nofollow noopener">medium.com/@matous.elphic…

Spatial profiling technologies illuminate the tumor microenvironment dlvr.it/SksxwR