Bhandoola_Lab

Arundhoti Das' review on ILC development was published, shortly after she started her own lab. Yi Ding and Christelle Harly are co-authors. nature.com/articles/s4159…

cell.com/immunity/abstr… NFIL3 resides at the apex - as far as I know, at least - of a transcription factor hierarchy that initiates innate lymphoid specification.

Much to add. Two long obsessions, finally published last year. First, this one: journals.plos.org/plosbiology/ar… Is thymic involution consequential for immune responses? If you could figure out how to prevent it, or reverse it, would it matter?

@HBorgesdaSilva Congratulations!

At least some things are going well!

@DrAntonioPagan @CFI_UMN Congratulations, Antonio! What a pleasure to see your well-deserved success.

More than 12 years ago, I won my grad program’s Golden Pipetman Award, which included a pipet set. I’ve been saving it in mint condition until I got my own lab. Today I finally opened it! 😂@CFI_UMN

Our colleagues will of course decide whether the new NK classification proposed by @EricVivier1 is useful. What their decision, I do think a classification that makes sense of both mouse and NK subsets would be very useful to the field.

Our contribution was to show that mouse NK cells develop by 2 pathways, and that the transcriptional signatures that defined these 2 mouse NK subsets also distinguished human NK subsets defined by CD56.

Glad to have contributed to the work by Rebuffet, @EricVivier1 and colleagues, reposted below.

Vivier and colleagues integrated scRNA-seq and CITE-seq data to provide a resource of human NK cell heterogeneity in healthy tissues and in the tumor setting. Read it here: rdcu.be/dM61D nature.com/articles/s4159…

And here are the links to the two new papers in Nature Immunology. From us and our collaborators @SimonGrassmann, @SunLab_Official, @BelkaidLab nature.com/articles/s4159… From the lab of Bendelac and McDonald: nature.com/articles/s4159…

And here is the thoughtful N&V from Emma Patey & @bjorkstrom_lab nature.com/articles/s4159…

Such a bittersweet surprise to be back to back in Nature Immunology with Albert. To my thinking, our two papers are very complementary.

The original papers are here, one from our lab, one from the lab of Albert Bendelac. rdcu.be/dKS3i rdcu.be/dKS9d

Great summary from Emma Patey & @bjorkstrom_lab about the 2 recent papers studying NK cell developmental origins from the late Bendelac's lab & the Bhandoola's lab: nature.com/articles/s4159… ILCs with more nuance! Orginal studies: rdcu.be/dKS3i rdcu.be/dKS9d

Bhandoola and colleagues describe the existence of two developmental pathways that give rise to functionally distinct NK cell subsets. Read it here: rdcu.be/dKPp7 #Abs1" target="_blank" rel="nofollow noopener">nature.com/articles/s4159…

The CCR media team has a succinct outline of this latest work from our lab: twitter.com/NCIResearchCtr…

Online now: Transcription factor Tox2 is required for metabolic adaptation and tissue residency of ILC3 in the gut dlvr.it/T63Tgk

science.org/doi/full/10.11… Other recent work from our lab. Stay tuned for more.

And here's the link to the paper itself, below. nature.com/articles/s4158…

Bone marrow plasma cells require P2RX4 to sense extracellular ATP rdcu.be/dyDzS The link is to a web-readable version of our lab's first paper on plasma cells. From a very fun collaboration between our lab at the National Cancer Institute and David Allman's lab at Penn.