BiocEM Cambridge

Team headed by Amanda Chaplin reports the cryo-EM structure of a DNA-PK trimer, which is a key enzyme for DNA double-strand break repair and they discuss the potential for higher order DNA-PK assemblies @AmandaChaplin10 @BiocEMcam @uniofleicester cell.com/structure/full…

Yay, our new pre-print - many congrats to Zhan Yin @PellegriniLab! 👏👏🥳 CryoEM insights into RNA primer synthesis by the human primosome biorxiv.org/content/10.110…

A year after she won the Lister Prize, we catch up with @AmandaChaplin10 to learn more about her work on DNA breakage and repair, and discover how the award will help her pursue her research goals 🔬 Read more here: lister-institute.org.uk/in-conversatio…

Research Associate (Fixed Term) @Cambridge_Uni jobs.cam.ac.uk/job/41419/ Great job opportunity at @CamBiochem in the @PellegriniLab . If you're interested in molecular mechanisms of DNA repair and replication, please apply and join us. We're looking forward to your application! 🙂

In this short article we provide evidence of these higher order assemblies, and discuss the potential formation of filament like assemblies, whilst giving our opinions of potential biological roles of such assemblies.

@AmandaChaplin10 @CharbonnierJea7 @CamBiochem Within this dataset we noticed the presence of a small population of particles representing higher order oligomers of DNA-PK. These are able to form via the combination of the two previously reported dimer forms.

Happy to share the latest work by @AmandaChaplin10 in collaboration with Kathy Meek, @CharbonnierJea7, ourselves @CamBiochem and others cell.com/structure/full…

@AmandaChaplin10 @CamBiochem @LeicStructBio @CharbonnierJea7 Also check out the related research article from @YuanHe_NWU science.org/doi/10.1126/sc…

@AmandaChaplin10 @CamBiochem @LeicStructBio This was part of a highly collaborative project including ourselves at @BiocEMcam, @CharbonnierJea7 , Kathy Meek, Patrick Calsou and others

The latest work from @AmandaChaplin10, work initiated at @CamBiochem and continued at @LeicStructBio science.org/doi/10.1126/sc…

Congratulations Amanda - keep up the stunning work!

Midlands Cryo-EM Facility @uniofleicester has a permanent post for an Experimental Officer to assist/ train users on everything Cryo-EM incl sample preparation, data collection &processing. We have a Titan Krios G3-Bioquantum-K3, screening microscope etc jobs.le.ac.uk/vacancies/5260…

New work from @_M_Carminati shows that dephosphorylation of RNA polymerase II by CPF (the 3' end processing machinery) promotes Pol II dimerisation. @mcemremnv @MRC_LMB @ERC_Research

The Miller lab @UnivCamPharm is looking for an enthusiastic postdoc to study antibody modulation of ion channels! A previous relevant publication from our group is nature.com/articles/s4158… Job details 👉 jobs.cam.ac.uk/job/35285 DEADLINE 15th JULY

The Miller lab is delighted to announce its first publication! Mechanisms of inhibition and activation of extrasynaptic alpha-beta GABAA receptors. nature.com/articles/s4158…. @Nature @vikrambabu @UnivCamPharm @BiocEMcam and Smart Lab @uclnpp

Happy to share our paper out in @Nature, which provides insights into activation and inhibition of a subset of extrasynaptic GABA(A) receptors. @PMillerLab @UnivCamPharm @BiocEMcam and Smart Lab @uclnpp nature.com/articles/s4158…

Excited to share our latest cryo-EM work @Nature of Blundell group @CamBiochem @BiocEMcam on ligand regulation of DNA-PKcs, a key kinase in DNA damage response and repair. Inhibitor mode of action now better understood and more to explore! Check it out: nature.com/articles/s4158…