Bleichert Lab

Our study on how the human MCM2-7 helicase is loaded onto replication origins 🧬 is now online @Nature! 🎉 Our findings reveal that unlike in yeast, human MCM loading does not require ORC6 and can occur through multiple pathways. Read more here: rdcu.be/d1F6S

Our article "MCM double hexamer loading visualized with human proteins" published in Nature today! ❄️🔬🧬🎉🥳 Great collaboration with John Diffley's lab. Congratulations to Florian Weissmann, Julia Greiwe and all other authors! rdcu.be/d1F7m

Great kickoff for the EMBO EMBL Replication symposium with amazing structural and functional insights into initiation, elongation and histone recycling 🧬♻️ @TyeBik @CostaLabCrick @BleichertLab @Speck_Lab Chistol @Lopes_Lab Méchali @YardimciLab 🙌 #EESReplication @EMBLEvents

We're excited to announce a tenure-track or tenured faculty position in Cellular Biophysics and Structural Biology! We are especially excited to hear from candidates who develop in situ approaches in structural cell biology. Join us in MB&B! Apply now at apply.interfolio.com/151559

Congrats to grad students Ran Yang and Olivia Hunker for giving a wonderful talk at the MB&B retreat and also for winning poster awards! The lab had a great time socializing with our colleagues and hearing about all the amazing work being done in the department.

Incredibly cool work from our lab neighbors!!

Here is a recent posting for a Lecturer position with the Department of Molecular Biophysics and Biochemistry (MB&B) at #Yale University. Please consider joining our research and educational community @YaleMBB and contributing to these important missions! apply.interfolio.com/145019

New preprint with the latest work from our lab! Grad students Ran Yang and @okhay97 demonstrate reconstitution of human origin licensing using purified proteins.

Beautiful work from our lab neighbors!

Easy to mix the two up 😅 #MarchMadness

Thank you to everyone who came to our Thanksgiving themed science social on Friday. We had a wonderful time sharing food, drinks, and conversation with you all! Also shout-out to our co-hosts in @LabPaulsen for doing a fantastic job!

Yale MB&B is seeking a Lecturer to contribute to our educational mission. Please consider joining our scientific community and using your skills for teaching biochemistry. You will work with fantastic colleagues and enthusiastic students! @YaleMBB apply.interfolio.com/114946

Our GSMI panel “Grad Student Panel on: PhD admissions in the Biological Sciences” will be NEXT WEEK on10/23 at 2:30pm EST Learn how to craft an effective PhD application and what interviewing was like from our grad student panelist! #CLGSMI Register ➡️ cientificolatino.com/eventbrite

The lab had a great time at the @YaleMBB retreat last week. Congrats to Olivia for delivering a fantastic talk and to Ran for winning the poster award!

Congratulations to graduate student poster award winners, The Pengxin Chai, Ran Yang, and Chrishan Fernando!

Excited to see this story finally in press! Happy to be a part of the team and congrats to everyone involved. 👇🎉

Yale is hosting the 10th NE Cryo-EM Symposium Oct 27th - should be a great day full of exciting talks and posters! Register at campuspress.yale.edu/10thcryoemsymp…

We folded over 40,000 pairs of ~300 human #genomemaintenance proteins with #AlphaFold multimer. Check out all the structures and the analysis at predictomes.org! #cshreplication

Taking a moment to check out the beautiful beach @CSHL before the start of #CSHLdnarep . Excited for a great meeting!