Abha Karki Rajbhandari, PhD

I want to share this research was inspired by me-search: everyday yoga practice that involves breathing and meditation and contemplation to know more biologically!

What determines whether a cell lives or dies? This Review argues that metabolism is the ultimate gatekeeper. Energy status, mitochondrial function, redox balance, and lipid metabolism dictate how regulated cell death unfolds, offering new targets for treating cancer and degenerative diseases. #Immunometabolism #CellBiology cell.com/cell-metabolis…

Still taking this in. It's been a long road, and I'm deeply grateful to my mentors, lab mates, friends, and family who have been part of this journey. Thank you to @NIH_NINDS for the opportunity to join the #DSPAN Scholar community. Excited for this next chapter!

EXCITING PAPER! In this review, Drs. @jainparul321 & Daniela Schiller synthesize research across various domains to trace how relationships develop from initial impressions through repeated interactions to stable social bonds & networks. @NeuroCellPress 👉 cell.com/neuron/abstrac…

🧠🏃 New preprint exercise neuroscience from the lab! We built a multi-organ spatial metabolomic atlas of long-term exercise in mice. Six organs. 224 metabolic features. Coordinated inter-organ remodeling. The biggest surprise? The brain reshaped its metabolism the most, region by region. We took the same approach into PS19 tau mice. Exercise cut over 70% of observable tau pathology in the hippocampus and restored the mitochondrial metabolome. Integrated proteomics + spatial metabolomics pointed to one convergent node: NADH dehydrogenase Complex I. So we tested it. We expressed yeast Ndi1 in PS19 neurons. No exercise. This alone raised brain antioxidants, restored shuttle metabolites, and reduced tau pathology. Boosting Complex I activity reproduces the core anti-tau effects of exercise. A molecular handle on why movement may protect the aging brain. biorxiv.org/content/10.648…

📣📣We are recruiting 1-2 postdocs at Northwestern University Feinberg School of Medicine. We studies how neuropeptides shape circuit function and behavior, and psychiatric disease using Neuropixels, calcium imaging, and optogenetics. Pls RT! More info: haolilab.org

@niroshajmurugan 💯

We don't often think of the brain serving any role other than the leader in whole body communication. But the human body is an information-exchanging system that is largely decentralized. Signaling dynamics should always be considered in the greater context of the whole. Just as forests are missed for trees, we often miss the orchestra of human physiology for the individual instruments and players that are the organs.

Internal rhythms and their importance!

The results of a 2024 study are among a growing number suggesting the heartbeat quietly shapes how the brain processes information. These findings also raise the uncomfortable possibility that internal rhythms frequently treated as background noise may be subtly skewing results in neuroscience experiments. Some researchers are now warning about the issue, and a paper published in April lays out guidelines for standardizing how studies should document and account for these internal rhythms. Learn more: scim.ag/4xKmMQo

Your organs aren't just following orders from the brain. A new Yale study finds that organs like the heart, lungs, and intestines build and shape their own nervous systems, then communicate back to the brain in a two-way conversation. One of the most striking findings is that heart tissue can reprogram neurons from the gut to start behaving like heart neurons. Researchers say the discovery could eventually open new paths for treating conditions like Parkinson's disease and other organ-based illnesses. See what else researchers found: bit.ly/4aD8qYd

@itchdoctor @IcahnMountSinai Congratulations Brian ✨

After almost five meaningful years at the @IcahnMountSinai, I’ll be wrapping up my time here at the end of June and closing this chapter of my academic career. I’m deeply grateful to my colleagues, trainees, collaborators, and leaders at Mount Sinai for the opportunities to build programs together and push the science of neuroimmunology and care of inflammatory skin (and other) disease forward — it has been a privilege to grow alongside such a talented community. In July, I’ll be joining the Feinstein Institutes for Medical Research & @NorthwellHealth as the inaugural Chief Biotechnology Officer, focusing on building new bridges between discovery, clinical research, and biotech across the health system. I’m excited about the chance to help accelerate translational science at scale and to work with new partners across academia, industry, and venture. My lab will continue to focus on foundational science in neuroimmunology. More details soon. To everyone I’ve had the chance to work with so far — thank you. I’m looking forward to staying in touch, finding new ways to collaborate, and continuing to advance the field together from this new perch.

The protein Npas3 regulates the energy metabolism of astrocyte cells and is necessary for neuronal function and cognition, a new study shows. @Jacobs_Med_UB @UBuffalo scim.ag/3SJCLhA

Such a great article on interoceptive awareness, and how the brain constantly listens to the bodily signals like heart rate, breathing, gut functions etc and understanding how these signals arrive in the 🧠 is an important research area! technologyreview.com/2026/06/12/113…

Scientifically, yoga trains self-regulation through breath, attention, interoception, emotional balance, and body awareness. Yoga has given me so much, and I am deeply thankful for its presence in my daily life. 🙏✨

The Sanskrit root yuj means to yoke, join, or unite: body with mind, breath with awareness, action with intention, and the individual self with something larger.

Happy International Yoga Day. Yoga is often seen as stretching, flexibility, or posture. But in its deeper meaning, yoga is a path of integration, wholeness, and awareness.

As we approach the six-month mark since opening our doors, I'm excited to share our lab website and introduce our team at @SinaiHeartBlood @IcahnMountSinai. Check out what we've been up to and reach out if you're interested in joining us or collaborating! timothyckennylab.com

Adipose or fat tissue is far more than a fat depot—it acts as a metabolic command center, coordinating whole-body health through hormones, metabolites, extracellular vesicles, and neural circuits. When these signaling networks break down with aging or disease, metabolic dysfunction follows. #Metabolism #Aging #PrecisionMedicine nature.com/articles/s4157…

We are delighted to share the latest findings from the lab in Nature! We report mutation-dependent effects of sleep and exercise on clonal hematopoiesis (CH) and its associated atherosclerosis. nature.com/articles/s4158…

Slow breathing impacts inter-organ dynamics modulating brain function and risk behavior: Neuron cell.com/neuron/fulltex…

@Sciolino_Lab @PNBUConn Congratulations Natale 👏✨🎊