Broad Institute

🧵 Introducing SpatialFusion: a lightweight #multimodal #FoundationModel for pathway-informed spatial #niche mapping. 📄 doi.org/10.64898/2026.… It combines #histopathology and #SpatialTranscriptomics to identify functional microenvironments in tissue. Here’s what we found 👇

Delighted to share our proteomics study by @Jiwoo__Lee @mit_hst @harvardmed & @BellomoTiffany @MGHVascular prioritizing TNFR pathway proteins & recurrent CAD events sciencedirect.com/science/articl… @JACCJournals #JACCAdv

🎉 We are excited to share new work led by @Schmidt_Center postdoctoral fellow @JoYatesResearch: SpatialFusion, a multimodal foundation model that identifies tissue niches based on pathway activity—not just spatial proximity. Learn more ⬇️ @broadinstitute

After a harrowing mental health crisis, a family’s giving to the Broad Institute’s research tops $1 billion trib.al/A5KSnaB

We are incredibly grateful to The Stanley Family Foundation for their transformative support of bipolar disorder and schizophrenia research. bostonglobe.com/2026/03/18/bus…

🎉 Congrats to @Schmidt_Center’s @ChujunHe123, @AmodioMatt, Orr Ashenberg, Caroline Uhler and colleagues on their Nature Communications paper! They introduce TRIM, integrating single-cell RNA + TCR data to study immune responses to cancer immunotherapy. #Abs1" target="_blank" rel="nofollow noopener">nature.com/articles/s4146…

Join us tonight online or in person: broadinstitute.swoogo.com/discovery26

New work with @CarolineUhler, now online in @NatureComms! We developed TRIM, a multimodal framework integrating T cell RNA and TCR profiling to predict T cell responses to cancer treatment. nature.com/articles/s4146… @broadinstitute @MGHMolBio @MGBResearchNews

The Stanley Family Foundation has renewed its commitment to psychiatric research at Broad Institute, bringing its total investment to more than $1 billion. This funding has advanced schizophrenia/bipolar disorder research, opening new paths to therapies. broad.io/SC-News

Join us March 18 at 6PM ET in Cambridge, MA (or online) for a Broad Discovery Series talk with Heidi Greulich and Matthew Meyerson, “The story behind a new therapy for lung cancer patients.” Register: broadinstitute.swoogo.com/Discovery26

In our latest, we made + examined simulation frameworks for biologically-informed neural networks in cancer genomics and showed how germline + somatic integration shifts gene importance rankings (👋 BRCA2), even w/o gains in predictive accuracy... Congrats Gwen Miller et al!

A common genetic variation could have a major impact on who develops aortic stenosis, @UCSFCardiology/@broadinstitute researchers found using a deep-learning model to analyze ~60,000 UK patient records. ucsfh.org/4b2VKKV

A member of the Class of 2026, Feng Zhang joins the Hall of Fame in recognition of his transformative work advancing human health through engineered CRISPR-Cas genome-editing systems. Learn more about this new Inductee! ow.ly/YHxs50YrigZ #NIHF2026

Attention science/health reporters and editors: applications are open for Broad’s 2026 Media Boot Camp! Join us in Cambridge April 30–May 1 for a deep dive into emerging stories in biomedicine. Hotel & meals provided. Apply by next Friday, March 20: broad.io/mediabootcamp

New study, in collaboration with @Honda1Kenya, out now in @Nature. We show how a low protein diet drives a microbiota-dependent induction of thermogenic brown adipocytes via FXR & FGF21 pathways. nature.com/articles/s4158…

New research finds that the gut microbiome fine-tunes fat tissue in mice in response to diet, converting it from energy-storing fat to more energy-burning fat when dietary protein is low. broad.io/Fat-Cells-News

The recording of "New approaches and data sources for coding variant interpretation" by @ccassa is now available: youtu.be/8YiHnealbEc. This talk is part of @broadinstitute's MPG Primer series. For more info, check out broad.io/MPGPrimer.

Rescheduled to March 18 at 6 pm ET. Register: broadinstitute.swoogo.com/discovery26

Join the @Schmidt_Center on Monday, March 9 at 4:00 pm (🍪at 3:30 pm) for a colloquium featuring Grégoire Altan-Bonnet, Deputy Chief, Laboratory of Integrative Cancer Immunology, National Cancer Institute. Register here: ericandwendyschmidtcenter.org/events/gregoir… @broadinstitute

The Catalyst program, led by Alabama nonprofit Southern Research, Broad Clinical Labs, and @myomeinc, provides free genetic testing to adult residents across Alabama to improve medical care and address chronic disease. Learn more: broad.io/BCL-Catalyst