Broad Institute

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Broad Institute

Broad Institute

@broadinstitute

A multidisciplinary community of researchers on a mission to improve human health.

Cambridge, MA, USA Katılım Nisan 2009
3.5K Takip Edilen99.9K Takipçiler
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David R. Liu
David R. Liu@davidrliu·
Today in @NatureBiotech we report a new suit of PE8 prime editor proteins. PE8 variants were developed from laboratory-evolved PE6 proteins using AI-guided protein redesign. This approach combines recent advances in computational protein design and directed evolution to increase prime editing efficiency, especially in transient therapeutically relevant delivery settings such as mRNA+pegRNA electroporation into primary cells, eVLP delivery of prime editing RNPs, and LNP-mediated mRNA+pegRNA delivery in mice. drive.google.com/file/d/13VTcAs… 1/11
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Allen Jiang
Allen Jiang@AllenYJiang·
Excited to share the first co-first author paper from my postdoc in @davidrliu’s group @broadinstitute, out now in @NatureBiotech! We used AI-guided computational redesign to develop new PE8 prime editors. See David’s thread below!
David R. Liu@davidrliu

Today in @NatureBiotech we report a new suit of PE8 prime editor proteins. PE8 variants were developed from laboratory-evolved PE6 proteins using AI-guided protein redesign. This approach combines recent advances in computational protein design and directed evolution to increase prime editing efficiency, especially in transient therapeutically relevant delivery settings such as mRNA+pegRNA electroporation into primary cells, eVLP delivery of prime editing RNPs, and LNP-mediated mRNA+pegRNA delivery in mice. drive.google.com/file/d/13VTcAs… 1/11

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David R. Liu
David R. Liu@davidrliu·
Today in @NatBiotech, we report the directed evolution of structured RNA motifs that enhance the efficiency of prime editing. Iterated high-throughput pooled screens and mutagenesis of these small RNA elements improved transient pegRNA lifetime. drive.google.com/file/d/1Nyt_SS… 1/11
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Zhi Yu
Zhi Yu@ZhiYu_ACGT·
🎉Happy to share our (@LinkeLi_MGH @tigerstatdoc @M_Mesbah_Uddin @abhinrl @pnatarajanmd me) collaborative article with Reuben & Santhosh's team at @IUMedSchool, just out in @BloodPortfolio! Clonal hematopoiesis of indeterminate potential (CHIP)🧬is linked to multiple organ systems — heart, liver, brain — what about the colon? And if there is a causal link, can we do something about it? Using Dnmt3a-mutant mouse 🐭models of colitis and human🧓data from UK Biobank & Mass General Brigham, we show that CHIP increases inflammatory bowel disease (IBD) risk; further, APE1/Ref-1 inhibitor APX3330 can ameliorate CHIP-driven IBD, potentially breaking the CHIP-disease link. 🔗sciencedirect.com/science/articl…
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Blood Journals Portfolio@BloodPortfolio

New issue of Blood out now featuring WM evolution during ibrutinib therapy, Bidirectional relationship for CHIP and IBD, Targeting DHODH in B-ALL and more. Explore here: ashpublications.org/blood/issue/14… #BloodJournal #NewIssue

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David R. Liu
David R. Liu@davidrliu·
Today in @ScienceTM, we report the use of in vivo adenine base editing to correct a variant causing Dravet syndrome, a severe childhood epilepsy and neurodevelopmental disorder, substantially ameliorating disease symptoms and extending lifespan in an animal model. 1/13 drive.google.com/file/d/12rcxew…
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Eric and Wendy Schmidt Center
Eric and Wendy Schmidt Center@Schmidt_Center·
🎉Congratulations to our symposium poster and short talk winners! 🥇First: @AdaFang_ (poster 34) 🥈Second: @AnushChP (poster 24) 🥉Third: @JoYatesResearch (poster 13) 🥉Third: Mahshid Heidari, Mina Karimpour (poster 42) 🏆 Best Short Talk: Maile Hirschmann, @dawnchenx
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Sumaiya Iqbal
Sumaiya Iqbal@Sumaiyalqbal·
The 2026 Q1-Q2 update for the @broadinstitute Genomics 2 Proteins (G2P) portal is now online (g2p.broadinstitute.org)! Thanks to the team and funders! Here’s what’s new 👇
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Zhi Yu
Zhi Yu@ZhiYu_ACGT·
🎉Check out our largest CHIP GWAS to date of >1M participants, shedding light on how germline variation governs which somatic clones in blood expand with aging🧬 In parallel, we conducted CHIP PheWAS, linking CHIP to hematologic, cardiovascular, infectious, and other conditions🩸🫀🦠 medrxiv.org/content/10.110… @M_Mesbah_Uddin @AlexBickMDPhD @pnatarajanmd
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Pradeep Natarajan@pnatarajanmd

Our preprint led by @M_Mesbah_Uddin @ZhiYu_ACGT and with @AlexBickMDPhD describes the germline genetic drivers and phenotypic associations of clonal hematopoiesis of indeterminate potential across >1M individuals medrxiv.org/content/10.110… @medrxivpreprint

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Broad Institute
Broad Institute@broadinstitute·
Congratulations to core institute member Fei Chen (@insitubiology) and associate members Ryan Flynn and Jessica Stark on this well-deserved recognition and support for their research from @psscra!
Pershing Square Sohn Cancer Research Alliance@psscra

We are thrilled to announce the 13 winners of the 2026 Pershing Square Sohn Cancer Prize. Doubling our commitment, this year's scientists have been selected for their bold ideas and potential to transform cancer research. Please join us in congratulating: pershingsquarephilanthropies.org/news/pershing-…

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GTEx Portal
GTEx Portal@GTExPortal·
NHP-dGTEx V1 derived data is available for download from @GTExPortal. NHP-dGTEx V1 contains 421 Macaque samples (372 RNA-seq and 49 WGS) from 50 subjects and 333 Marmoset samples (314 RNA-seq and 19 WGS) from 20 subjects. bit.ly/4lV8tmI
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GTEx Portal
GTEx Portal@GTExPortal·
dGTEx V1 open access data is now available for download from @GTExPortal. dGTEx V1 contains 379 samples from 40 subjects. bit.ly/4rHwa3A #rnaseq
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David R. Liu
David R. Liu@davidrliu·
I’m honored to have been presented the Franklin Institute Bower Award for Achievement in Science by Kyle and Nicole Muldoon, the parents of baby K.J. (Kyle Junior), alongside @kiranmusunuru and @AhrensNicklas. Video from the ceremony: youtube.com/live/PFmFx2czD…
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Broad Institute
Broad Institute@broadinstitute·
Broad researchers from @CTSPeng's lab used their single-molecule tracking technology to reveal unexpected patterns of dimerization among EGFR family receptors, shedding light on their role in cancer. Learn more: broad.io/Peng-EGFR
GIF
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Tom Ulrich
Tom Ulrich@scribbler_tom·
Other mammals have so many abilities that we don't, but which could teach us a lot about health and disease. Join us for what promises to be a talk filled to the brim with great science and super-cute animal pictures!
Broad Institute@broadinstitute

Have you ever wondered what animal superpowers can teach us about our own DNA? Join us in Cambridge, MA (or online) for a Broad Discovery Series talk on Wednesday, May 20 at 6 pm ET with @eenork of @darwinsarkfnd. Register: broadinstitute.swoogo.com/Karlsson

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Keşfet

@NatureBiotech @davidrliu @NatBiotech @Schmidt_Center @LinkeLi_MGH @tigerstatdoc @M_Mesbah_Uddin @abhinrl