Caitlin Duncan

Spent a fabulous day exploring Brisbane getting ready for #RACI2022 @CurtinChem

@TB_Perth @MauroM3125 @CurtinChem Thanks Tom and thank you so much for all your help!

@CDuncs97 @MauroM3125 @CurtinChem Very nice 😊

Check out some of my work on Calix[4]arenes as Organogelators!#RSCPoster #RSCOrg @MauroM3125 @CurtinChem

@georginasauzier I think she thought she was helping, not hindering

Well this has been a god-awful day. Pls send photos of your animal companions. Bonus points for pets where they are clearly not supposed to be.

@debbiesilvester That’s good, it could’ve been a whole lot worse!

@CDuncs97 Thanks! They actually left a note, which is decent. Asked me to contact their grandad to sort it out. Assuming it was an uninsured P-plater, as Marcus said there were plenty of them out there today!

Someone left me a nice “gift” in the car park at work today 🙄🤔

@Furong_Lin @ismsc2020 @MauroM3125 Thanks for your question! This kind of HPV inhibition works by the calixarene binding to the surface of the L1 protein, which then results in the L1 protein being unable to assemble into the pentamer

@CDuncs97 @ismsc2020 @MauroM3125 What’s the mechanism for this kind of HPV inhibition?

Here’s part of my PhD work on the synthesis of calix[4]arenes for testing against Human Papillomavirus pentamer formation @ISMSC2020 #ISMSCPoster #macrocycles12 @MauroM3125 There is an image in the comments if you want to zoom in 😊

@alhaddad_nancy @ismsc2020 @MauroM3125 Thank you 😊 I would expect my calixarenes would interact through either ionic or H bonding. I have made other compounds to see if the calixarene is important for the activity, and that will likely help determine if there are also hydrophobic interactions occurring with the calix

@CDuncs97 @ismsc2020 @MauroM3125 Great work! Very interesting topic! I have read that your compounds aren't tested yet but i'm curious to know what type of interactions are involved in the binding of your calixarenes to the L1 protein

@LambertSimon18 @ismsc2020 @MauroM3125 Thank you! Previous work using calix[4]arenes and a pillar[5]arene functionalised with carboxylates has shown that they likely bind to an Arg residue. Since my compounds have the opposite charge to the carboxylate, it will be interesting to see what they do!

@CDuncs97 @ismsc2020 @MauroM3125 Interesting poster! Do you know where on the protein does the binding of the calix take place? Does the calix complex a Lys or an Arg?

@yingweiyang @NWhiteGroup @ismsc2020 @MauroM3125 Thanks, this is actually where the project originated from! It is nice to meet you 😊

@CDuncs97 @NWhiteGroup @ismsc2020 @MauroM3125 Great! Check out our related work published in 2014. pubs.rsc.org/en/content/art…

@Jrmie05546443 @ismsc2020 @MauroM3125 As for introducing them to the human body, I expect that depends on how active they are and how they behave in a biological system, so I am not sure at this stage 😀

@CDuncs97 @ismsc2020 @MauroM3125 Did you already try your molecule in vivo condition ? If yes, What's the host's selectivity in the cell ? How do you plan to introduce it in the human body ?

@Jrmie05546443 @ismsc2020 @MauroM3125 Thanks for your questions! Currently the project concept is very much in the investigation stage, with all testing on pentamer inhibition occurring in vitro. My compounds haven’t been tested just yet

@cindym_hong @SupraMolChem @ismsc2020 @MauroM3125 Thank you 😊

@CDuncs97 @SupraMolChem @ismsc2020 @MauroM3125 The animation is a really nice, concise touch!