Yuval Cohen

At Corbus, we are dedicated to developing treatments that aim to significantly improve patient outcomes in cancer care. Learn about our oncology pipeline: bit.ly/40qrinT #CervicalCancer #HNSCC

Super interesting paper from 2024 on psych AEs in sema phase 3 studies in obesity vs placebo. pubmed.ncbi.nlm.nih.gov/39226070/ Bottom line is that semi doesn't make those worse but some fascinating facts about psych AEs and weight loss emerge from this dataset. 1. 25-30% of participants had a psych condition at baseline. 15% were on psych meds. 2. Regardless of intervention, nearly 7% are still moderately depressed by end of study. 3. The greater the weight loss, the better the improvement in psych outcomes from baseline. Losing weight really did make them happier! 4. Initially, both placeo and sema slightly WORSEN as patients begin therapy but then both improve with sema improving measurably more than placebo.

Attending the BMO 2026 Metabolic Health Summit? @CEOCorbus will participate in the Emerging Companies Panel: What's Next in the Treatment of Metabolic Disease today, March 24, 2026 at 12:45 pm ET. bit.ly/3NDPUGR $CRBP #Obesity #MetabolicDisease

.@CEOCorbus will join a panel to discuss CRB-913, an orally delivered highly peripherally restricted CB1 inverse agonist for the treatment of #obesity, at the BMO 2026 Metabolic Health Summit tomorrow, March 24th. For event details: bit.ly/3NDPUGR $CRBP #MetabolicDisease

It's my version of doing Sudoku at breakfast 😆

Diving into the CDC database on Lyme is super interesting. cdc.gov/lyme/data-rese… 1. Cases nearly quadrupled from 2022...because of a new definition of what constitutes a "case". In fact, verified cases went from ~20K to now a figure of ~500K being cited as "potentially Lyme related". 🤔 2. Craziest age distribution ever: 5 year olds or 60-70 year olds. Nearly all white. Men a bit more than women. 3. It's nearly impossible to die from it. ChatGPT says 23 deaths over last 5 years. If one really believes the 500K figure, then 1/100K death per annum. That's pretty much the LEAST deadly thing I can imagine.

The fact that a paper with this flawed methodology is published in a Lancet journal gives me depression + anxiety!

The first 60 seconds of this clip are tragically negated by the last 30 seconds. "Politics in science are bad...except for MY politics" is not going to get us out of this mess.

Only someone who profoundly hates motherhood and the miracle that is childbirth could have chosen such an image. Just incredible.

@SnupSnus @Biomaven 100%. Still, not inhaling that tar is a huge step forward!

@CEOCorbus @Biomaven Or because they are nicotine delivery alternatives total nicotine user share is stable even slightly increasing

Cigarette smoking in the US falls below 10% of the population for the first time. statnews.com/2026/03/17/cig…

Paper has fascinating data and confirms that the biggest drops were related to socioeconomic factors among those ABOVE poverty line. Those below barely budged. This is not about taxes or affordability. It's middle class kids no longer finding it cool to smoke. The fatal flaw of the paper is that states most likely to have high taxes on cigarettes are also the ones with exactly the former demographic.

I'm looking forward to reading that but intuitively I find that hard to believe. It's so easy to get hold of out-of-state cigarettes and what has replaced them (vapes, cannabis, etc) is more pricy. Also the demographic most likely to have stopped smoking is the least sensitive to price issues. The opposite is also true : the demographic most likely to still smoke is the one with the least disposable income.

@SnupSnus The incentives are all wrong. They should be compensated for saving money. Right now, it’s exactly the opposite.

@CEOCorbus Your view is certainly a good one for a CEO to have! Obviously the burocrats will have to think about loosing their huget next year if they don't spent it!

I have a $100 budget for groceries. I go to the supermarket but discover that there are only $60 worth of groceries that meet my liking. No sane person would ever then go: "well, I still have $40 left so I might as well spend it on these garbage groceries I don't need or want.". What an odd thing to insist upon doing.

@jrkelly Don't know. Lots of automation on the manufacturing side (surprising) but I can't comment on the R&D side.

@CEOCorbus 👍 How did the discovery infrastructure look?

We just came back from our annual trip to China and the pace of progress in drug discovery and development is just...staggering.

@jrkelly Diversity of pipelines + infrastructure. Just mind boggling. We visited a new biologics manufacturing site (4 million sqf) that was built in under 2 years. Fully GMP ready. Just remarkable.

@CEOCorbus What stood out the most?

Weight loss with GLP-1 medicines does not result in a disproportionate loss of muscle mass or function in obese mice and humans: ⁦@CellRepMed⁩ cell.com/cell-reports-m…

"I am immensely interested in the geo-political opinions of this medical journal..." Said no sane person ever.