ClubCambronne

We're hiring! lulucambronne.org. Join a collaborative team of creatives who strive towards discoveries through innovation and critical thinking. We uphold high standards in scientific rigor and tackle challenging problems to glean insight into disease onset and progression.

The Cambronne Lab has recently received a High Impact/High Risk Research Award Grant for our work on Targeting Mitochondrial NAD+ in Leukemia! A big thank you to the Cancer Prevention and Research Institute of Texas!! @CPRITTexas

(8/8) - written by Lab Manager Ciara Fields along with Undergraduates Jesus Balderas and Ashley Gilliam

(7/8) The Cambronne Lab researches metabolism biology with molecules, namely NAD+. Vitamin Bs like nicotinamide, with help from NAMPT & NMNAT, synthesize NAD+ in the salvage pathway. William’s work isolated Vitamin Bs, enabling us to continue researching metabolism.

(1/8) In honor of our recent publication, we would like to make a thread commemorating UT’s immense history of metabolic biology!

Way to go @CambronneLab and collaborators! #TexasScience #WhatStartsHereChangestheWorld 🤘🎉 cns.utexas.edu/news/researche…

Kudos to colleagues in the @IlyaFinkelstein Lab! cns.utexas.edu/news/matching-…

Out today! Congrats @nora_kory and @DMSabatini! advances.sciencemag.org/content/early/…

Also watch for studies on SLC25A51/MCART1 from the Sabatini lab, led by Nora Kory biorxiv.org/content/10.110…… and the Superti-Furga lab, led by Enrico Girardi biorxiv.org/content/10.110…!

The really nice aspect of seeing these papers independently tackle the problem from such different directions means that the supporting evidence for the central discovery is now very, very strong. A big advance for our basic understanding of mitochondrial NAD+ metabolism!

Highlighting key contributions by: @timluongo @EllerJared @MuJie_Lu @dr_ohsopretty @fraith7 @CEPerry230

Thread (1/3): Best Science = Collaborative Science. We are pleased to share our latest work demonstrating NAD+ uptake in mammalian mitochondria by SLC25A51 transport. @nature @CambronneLab @BaurLab rdcu.be/b6YBL

(3/3) Measurements of free mitochondrial NAD+ in live cells; demonstration with recombinant system of direct transport activity in vitro; kinetic rate calculations; beautiful 3D reconstructions @EllerJared @MuJie_Lu @PaulOliphint

(2/3) Very proud of this #TexasScience group right here who knows how to band together as a team and get things done. #humblebrag #checkegosatthedoor #drivenbypursuitofscientifictruth @CambronneLab