Cell Research

タンパク質を切断するCRISPRシステム 多くのCRISPR-Cas9システムではDNAを切断するが、特殊なタイプではタンパク質を切断するらしい(Craspaseと命名)。構造解析などでそのメカニズムに迫っている。 生物学的にもツール開発的にもアツそう science.org/doi/10.1126/sc…

CRISPR-Cas keeps on giving. Never thought it could do RNA-activated protease activity. Beautiful mechanistic work with @AilongK group. Thanks Chunyi Hu and Sam van Beljouw, and all co-authors. science.org/doi/10.1126/sc…

Very beautiful work with high potential for applicaiton development. Craspase is a CRISPR RNA-guided, RNA-activated protease science.org/doi/10.1126/sc…

Researchers use X-ray crystallography to reveal the structure of "T-box" elements in Mycobacterium tuberculosis. T-boxes recognize when a cell is deficient in a specific amino acid & are only found in bacteria, making them good drug targets. phys.org/news/2019-11-s…

Excited to share my work on tRNA recognition by a full-length T-box RNA in @NatureSMB. An elaborate structure allows the T-box to decode and sense the aminoacylation status of the tRNA. Could their ancestors be #RNAworld tRNA-synthetases? rdcu.be/bW3zV

Fun review article by our lab on how a viral domain invaded the fungal ancestor, expanded through duplication, and became associated with important fungal traits. authors.elsevier.com/a/1ZsEB,LqAZJg…

This start a new era for CRISPR or gene editting?😄 How do you think about this?

Hi guys, How about this article: Interferon-inducible cytoplasmic lncLrrc55-AS promotes antiviral innate responses by strengthening IRF3 phosphorylation / nature.com/articles/s4142… / rdcu.be/bHqSQ / # Innate immunity # Long non-coding RNAs

Amazing paper from Harvard medical school are talking about circular RNA and tumorigenesis. So impresive. rdcu.be/bHqOf / nature.com/articles/s4142…

A good article from our Cell Research (CR). haha 😁😁😁