Lukas Cermak Lab

Excited to share our discovery: CRL4-DCAF12 regulates DNA replication by ensuring proper nascent MCM2-7 complex assembly. This prevents genome instability and diseases like cancer.🙏Big thanks to @HanaSedlackova1 for the great collaboration! biorxiv.org/content/10.110…

📢 Happy to share our bioRxiv preprint on how CRL4-DCAF12 regulates the cellular level of MCMBP, a chaperone of nascent MCM2-7 complexes, to ensure error-free genome duplication. The full story can be found here: lnkd.in/eCjVNQks

now published on line @CellCellPress sciencedirect.com/science/articl…

Huge congrats to @yadav_anoop101, @aabdirov1, and @KatarinaOndrusk for their fantastic contributions to this elegant study! @imgprague @BFUavcr @CzechAcademy #DNAreplication #CancerResearch #proteasome #ubiquitin

CRL4-DCAF12 fine-tunes replication by degrading MCMBP, enabling proper MCM assembly and accurate replication speed. Without it? Faster forks, DNA damage, instability—and a cancer risk.

Excited to share our discovery: CRL4-DCAF12 regulates DNA replication by ensuring proper nascent MCM2-7 complex assembly. This prevents genome instability and diseases like cancer.🙏Big thanks to @HanaSedlackova1 for the great collaboration! biorxiv.org/content/10.110…

What a wonderful, inspiring, and collaborative meeting at #EMBOubiquitin2024! In 1998, I attended my first conference—same #Cavtat, same @iDikic2. Huge thanks to the organizers @YMerbl, @YKulathu, @LabJoazeiro, @polosimona1, and @EMBOevents!

Fantastic work by @NikolDibus and an excellent collaboration with Michele Pagano @paganolab and Ondrej Stepanek @AdaptiveImmuni2! Hopefully, more journals will endorse papers focused on addressing the confusion published across all levels. embopress.org/doi/full/10.10…

🔬 Join our research team! 🎓 Explore the vital role of the proteasome in cancer cell apoptosis. 🧬Seeking passionate PhD candidates in molecular biology. img.cas.cz/group/lukas-ce… 🧪#PhDPosition #CancerResearch #MolecularBiology

Do papers improve after peer review? Only in a limited number of cases. Is it still worth the effort? Let’s eliminate the tyranny of peer review and publish only in BioRxiv. Is it too bold for @NIH to ask to use taxpayers’ money to perform research rather than enrich publishers?

A postdoc position is available in our lab 🔬. If you are interested in DNA replication & genome stability, please get in touch. Thank you for sharing! More information also here: ibp.cz/en/offers/job-…

In between experiments... #freshblood

Great talk at @imgprague by Vincenzo D'Angiollella @VdangioE3lab on #neomorphic substrates and his own Cyclin F. It's always a blast to meet other Pagano lab @paganolab alumni.

@AdaptiveImmuni2 @msmtcr Myslím, že je to každým dnem zřejmější.

"Nastolili jsme cestu menší byrokracie a efektivnější podpory, aby vědci nemuseli počítat každou korunu." Zajímavé, @msmtcr nastolilo cestu přesně opačnou. Která cesta bude úspěšnější?

Keep following us :)

First author Nikol Dibus @NikolDibus had dedicated her doctoral life to FBXO38, so far the only CUL1-dependent substrate receptor mutated in a hereditary form of neuromuscular atrophy. I can see more great stories coming out about this unique ubiquitin ligase.

FBXO38 does not control PD-1 stability biorxiv.org/content/10.110…

Matters Arising: FBXO38 does not control PD-1 stability biorxiv.org/cgi/content/sh… #bioRxiv

SCF-FBXO38 does not control PD-1 stability biorxiv.org/content/10.110… 🧵 1/8

🚨 📢 My lab is looking for a highly motivated Research Associate to join our team @WCMCPathology @WeillCornell ! Learn more about us at lnkd.in/e6nGUdwG. Spread the word!! linkedin.com/jobs/view/3309… 📢