Joazeiro Lab

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Joazeiro Lab

Joazeiro Lab

@LabJoazeiro

💙E3 Ubiquitin ligases and Protein Quality Control: mechanisms, functions and relevance for aging-related diseases, in particular neurodegeneration

Heidelberg, Germany Katılım Mayıs 2019
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Joazeiro Lab
Joazeiro Lab@LabJoazeiro·
The Mother of All Ribosome Collisions Life before #ubiquitin: B. subtilis MutS2/RqcU senses translational stalls that lead to #ribosome collisions, then elicits degradation of the incomplete nascent-chains. Excited to share our findings, online @Nature today. #RQC
ZMBH - Center for Molecular Biology Heidelberg@ZmbhH

A team of researchers led by ZMBH's PIs C. Joazeiro @LabJoazeiro and S. Pfeffer @PfefferCryoLab discovered how the bacterial MutS2 protein prevents damage by stalled ribosomes! Further details in Nature nature.com/articles/s4158…

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Mohit
Mohit@mohitasya·
@LabJoazeiro Many congratulations, Claudio! Hope you find the best candidates!! 🥂
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Joazeiro Lab
Joazeiro Lab@LabJoazeiro·
With this new funding, we’re hiring PhDs and #postdocjobs Our #ERCAdG studies on the role of #RQC #ribosome #ubiquitin in #neurodegeneration will include using iPSCs, i-neurons, mammalian TC. The lab also has ongoing projects on #mitochondria and bacterial RQC.
Joazeiro Lab@LabJoazeiro

Thrilled and honored to receive the #ERCAdG! This will fund us for the next 5 yrs for groundbreaking research My project SuTra focuses on the Surveillance of Translation, from sensing #ribosome stalling to #RQC. We aim to learn how defective surveillance causes neurodegeneration

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Joazeiro Lab
Joazeiro Lab@LabJoazeiro·
And the flier for PhD jobs. Thanks!
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Joazeiro Lab
Joazeiro Lab@LabJoazeiro·
Thrilled and honored to receive the #ERCAdG! This will fund us for the next 5 yrs for groundbreaking research My project SuTra focuses on the Surveillance of Translation, from sensing #ribosome stalling to #RQC. We aim to learn how defective surveillance causes neurodegeneration
European Research Council (ERC)@ERC_Research

📣 Good news: 281 top researchers have just won ERC Advanced Grants! The new funding, worth nearly €721 million, is part of the 🇪🇺 EU’s #HorizonEurope programme. Read more 👉 europa.eu/!JYKxkD #ERCAdG #FrontierResearch @EUScienceInnov

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Joazeiro Lab
Joazeiro Lab@LabJoazeiro·
Thanks for your many contributions, Ivan. And of course, we would not have known about this amazing venue had you not pioneered meetings here.
Ivan Đikić@iDikic2

Impressive #EMBOubiquitin24 in #Cavtat with more than 300 participants & active discussions at posters. Superb success- thx to the organisers @MerblYifat76992, @YKulathu, @LabJoazeiro, @polosimona1, @EMBOevents 🙌👏🫶👍 The hotel and weather matched the quality of science 😊 ⁩

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Joazeiro Lab
Joazeiro Lab@LabJoazeiro·
The credit to brilliant and fun thesis defense poster goes to Giuliano Arcaio
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Joazeiro Lab
Joazeiro Lab@LabJoazeiro·
Federico followed up on our discovery that bacteria also have an RQC pathway. In collab w @PfefferCryoLab, he elucidated mechanisms underlying Ala-tailing by RqcH (the homolog of Rqc2/NEMF), and discovered a factor that senses collided ribosomes upstream of RQC (hence, RqcU).
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Joazeiro Lab
Joazeiro Lab@LabJoazeiro·
Congratulations to my stellar (ex) PhD student Federico and all the awardees and honorable mentions for this achievement!
IMP@IMPvienna

@huangkun1995 @EdinburghUni @irmantas_mogila @VU_LT @AtvuLsc @schulluc @mpi_marburg @maxplanckpress @ctstankey @Dr_James_Lee @crickinstitute @ToneyanSh @pkoo562 @CSHL @viennabiocenter honourable mentions: Christian Baca from @RockefellerUniv, Federico Cerullo from ZMBH Heidelberg (@UniHeidelberg), Pascal Devant from @Harvard, Leonard Ernst from @mpi_marburg @maxplanckpress 9/

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Jonathan Pruneda
Jonathan Pruneda@jnpruneda·
Bacteria can counter noncanonical lipid ubiquitination with a #ubiquitin esterase! Fantastic collaboration with @ThurstonLab and @CMBI_Szczesna, with @r_lacoursiere driving our side of the project using some amazing tools built by the Geurink lab.
Teresa Thurston@ThurstonLab

Excited to share our preprint on how a cytosolic bacteria evades LPS ubiquitylation and antibacterial autophagy through an effector with esterase activity. Led by @CMBI_Szczesna in the lab @ImperialInfect @CBRB_Imperial with superb collaborator @jnpruneda researchsquare.com/article/rs-298…

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Alessio Ciulli
Alessio Ciulli@alessiociulli·
Thank you @kyliejwalters @LabJoazeiro and Yue for the invitation to share the group’s latest story at this year’s @FASEBorg and for all your hard work putting together a fantastic program. It’s an honour to be a part of “the mother of all ubiquitins” and what a location too!
Alessio Ciulli tweet mediaAlessio Ciulli tweet media
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