Ayushi Chauhan

354 posts

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Ayushi Chauhan

Ayushi Chauhan

@Chauhan_AF

Assist. Prof. Lymphoma @MDAndersonNews via @GACancerCenter | @LombardiCancer | @Uconn

Houston, TX Katılım Ekim 2019
678 Takip Edilen628 Takipçiler
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Pallawi Torka
Pallawi Torka@PallawiTorkaMD·
Functionomics in DLBCL 🏃‍♀️💪 Do you treat older pts with DLBCL? If so, please consider taking this survey- docs.google.com/forms/d/e/1FAI… 15 min of your time will help us understand if/how fitness is being incorporated in decision making. 🙏 #geriheme #gerionc #lymsm
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Khushali Jhaveri
Khushali Jhaveri@JhaveriKhushali·
🧠 New phase II study in newly dx PCNSL: R-MVP + ibrutinib n=30, median age 69 CR/CRu 97% (29/30) with no refractory disease 25-mo f/u, median PFS/OS NR; 2-yr PFS 84% Toxicity manageable (cytopenias); no Aspergillus or PJP
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Ajay Major, MD, MBA
Ajay Major, MD, MBA@majorajay·
CNS relapse of LBCL after CAR-T @gloria_iacoboni #ASH25 - 1102 pts R/R LBCL: 79% CAR, 21% CIT - 1.6% incidence of CNS relapse after CAR (2.2% CIT cohort) - time from CAR to CNSr 4.7 mo Corroborates known CAR CNS penetration. Upfront CAR if high CNSr risk? #lymsm #tcellrx
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Ajay Major, MD, MBA
Ajay Major, MD, MBA@majorajay·
CD3xCD20 BsAb CNS lymphoma #ASH25 - 28 pts from CUBIC (22 glofi), 18 active CNSi - 6-mo PFS/OS 44%/81% - active CNSi: ORR 56% (CR 33%) - 67% received combo tx (BTKi, len, IT chemo) Outcomes with active CNSi similar to trials. Need more pts & longer f/u. #lymsm #tcellrx
Ajay Major, MD, MBA tweet mediaAjay Major, MD, MBA tweet media
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David Russler-Germain, MD/PhD
For Heme Onc fellows out there, two useful links re sample sizes: clincalc.com/stats/samplesi… cancer.unc.edu/biostatistics/…
Joachim Schork@JoachimSchork

Did you know you can calculate the exact sample size you need before you even start your study? A sample size calculation — also called a power analysis — helps you determine the optimal number of observations for your statistical analysis. It ensures your study is large enough to detect meaningful effects, but not so large that you waste resources. Key advantages of performing a power analysis: ✔️ Avoid underpowered studies that might miss real effects ✔️ Save time and costs by avoiding unnecessarily large samples ✔️ Tailor your sample size to the effect size you care about detecting ✔️ Choose your desired confidence level and statistical power for robust results ✔️ Works for a wide range of statistical tests, from t‑tests to ANOVA and regression ✔️ Supported by many free R packages, such as pwr The image shows on the left side how the required sample size changes depending on the expected effect size — smaller effects require much larger samples. On the right side, you see an example of a calculated sample size for comparing two groups using a t-test, showing exactly how many participants are needed per group for the desired confidence level and statistical power. Sign up for my newsletter to get more practical tips on statistics, data science, R, and Python. Check out this link for more details: eepurl.com/gH6myT #pythonprogramming #programmer #DataAnalytics #RStats #Python #datastructure #DataAnalytics

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Ayushi Chauhan
Ayushi Chauhan@Chauhan_AF·
@chadinabhan @ASH_hematology Yes, indeed! Trial data can be gleaned from many places but a nuanced view of access issues and research that truly benefits the majority is what we get with you! Thank you!
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Ayushi Chauhan
Ayushi Chauhan@Chauhan_AF·
Thank you @Medscape @MedscapeOnc for highlighting this rare disease 🧠! Giving this talk alongside the intrepid mentor and @HemOncWomenDocs champion @AshleySumrallMD and Dr. D’Angelo was the absolute best!#ASH25 🩸@MDAndersonNews @WomenInLymphoma #endcancer
Ashley Love Sumrall, MD, FACP, FASCO@AshleySumrallMD

We had a great turnout today at our @MedscapeOnc symposium on R/R #PCNSL! #ASH25 ❤️ SO much to look forward to in this space! Thx to Dr D’Angelo & my friend @Chauhan_AF for making it a great discussion! #btsm

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Toby Eyre
Toby Eyre@tobyeyre82·
FLIPI24: A Modern Prognostic Model and Clinical Trial Enrichment Tool for Newly Diagnosed Follicular Lymphoma | Journal of Clinical Oncology ascopubs.org/doi/10.1200/JC…
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Ajay Major, MD, MBA
Ajay Major, MD, MBA@majorajay·
SCNSL incidence based on COO/GEP in DLBCL #ASH25 - >2100 pts from LEO/MER - 5-yr incidence SCNSL by CNS-IPI: low 1.5%, intermed 4.9%, high 6.1% - non-GC & DEL with higher incidence of SCNSL - 82% occured in first 2 years Need to update prognostic tools w/ molecular data. #lymsm
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