Chowdhury Lab

Big congratulations to @SusanKilgas, who won a Poster Presentation Award at the 20th International p53 Workshop | p53 Conference, which took place last week in Toronto! Fantastic work! #p53biology

@arindam_datta1 @MolecularCell Thank you!

@ChowdhuryLab @MolecularCell Congratuations! Nice work.

New paper out today in @MolecularCell We show that proximal polyadenylation site (pPAS) within MRE11 sustains its transcription through promoter–PAS chromatin looping. Congratulations to first author Kaimeng Huang, all co-authors and collaborators. sciencedirect.com/science/articl…

Finally, we demonstrate that PAS‑mediated promoter looping broadly regulates DDR gene expression and genome stability, expanding the conceptual framework for how DDR factors are controlled.

Deletion of the MRE11 pPAS reduces MRN complex abundance and phenocopies hypomorphic MRE11 defects. We further find that loss of the pPAS triggers ectopic DNA replication and confluence‑induced cell death, revealing non‑canonical, non‑DDR functions linked to MRE11.

Excited to announce: EMBO Workshop: DNA damage response in cell physiology & diseases - 12–16 Oct 2026 - in stunning Sounio, Greece - fabulous speaker speaker lineup representing the cutting-edge of genome stability research Abstract deadline: 17 May: meetings.embo.org/event/26-dna-d…

We are looking for a candidate with hands-on experience in NGS to drive workflows in fundamental genome stability research and clinical genomics. This role offers the opportunity to work on sequencing projects both within our lab and in collaboration with clinical teams.

The Chowdhury Lab at the Dana-Farber Cancer Institute is hiring a Senior Research Technician! If you are passionate about NGS and its applications in cancer research, apply here: careers.dana-farber.org/job/650/senior…

Excited to share that Michelle Swift has been selected as an OCRA grantee! This support will help us study mechanisms of PARP inhibitor resistance in ovarian cancer and identify new therapeutic opportunities. ocrahope.org/research/curre…

Congratulations to @ChiaraMasnovo on receiving the @AmericanCancer Postdoctoral Fellowship! 🎉 Her project will be defining the DNA Repair Independent Mitotic Role of 53BP1 Mentor: Dipanjan Chowdhury Co-mentor: Alexander Spektor Well deserved recognition of outstanding work! 👏

Congratulations to @SusanKilgas on receiving the first place Best Poster Award at the DNA Damage Mutation and Cancer Gordon Research Conference for her poster on a novel layer of p53 regulation through TIRR 🎉

Congratulations to Michelle Swift on receiving the Best Short Talk Award at the #DRRSC26 Fusion Conference for her presentation on BRCA1/BARD1 regulation of DNA repair. 🎉 @Fusion_Conf

Excited to share our new paper from Sara J. Buhrlage lab & @ChowdhuryLab! We designed CAS-010, a selective, low nanomolar USP28 inhibitor that reduces p53 transcriptional activity, mimics p53 pathway loss & disrupts 53BP1-USP28 binding, offering new insights into USP28 function.

🧬 Grad students and postdocs in DNA repair/DDR: don’t forget to register for the 2026 GRS “Safeguarding the Genome” seminar — Feb 28–Mar 1, Ventura, CA. Keynote: @ChowdhuryLab. Abstracts due by Nov 23, 2025. Register here: 🔗 grc.org/dna-damage-mut…

📢 For all HaloTag lovers💙💚💛❤️💜🩶 we are excited to share that our work, in which we developed a new biotin-HaloTag ligand, is now published in @JCellBiol! Full link here: rupress.org/jcb/article-ab…

Excited to share our publication out in Science today! We define a role for the CST complex in DSB repair pathway choice. This study was conducted in close collaboration with Patrick Sung’s lab. Congratulations to Michelle Swift and all other authors! science.org/doi/10.1126/sc…

Thank you to @ChowdhuryLab (@Harvardmed, @DanaFarber) for joining us for a fantastic #WednedsayLectureSeries on "#DNA repair mechanisms in the context of cell cycle with implication in #cancer." 🧬 Hosted by the Si Lab.

📣 Excited to share our latest review on 53BP1’s function in replication stress, its role in fork protection, and the significance of 53BP1 nuclear bodies in this context! sciencedirect.com/science/articl…