Circulation Research

Huang et al found a critical driving role of endothelial #NOX1 activation in the development of #obesity & #metabolic syndrome Learn more at ahajrnls.org/4f8me07 @HuaLinaCai @LabFreed

Dionísio et al found that #macrophage specific deletion of the glycolytic rate-limiting enzyme #PKM2 leads to stabilization of #atherosclerotic lesions but not difference in plaque size. Learn more at ahajrnls.org/4e3Lwvb @l_tomas01

Chacon-Barahona et al studied how blood markers of #metabolism associate with #RV function in people with #PH ahajrnls.org/49iRXbd @JaneALeopold @FrantzDrBob @bborlaugmd @DebbieKwonMD @ebrosenzweig @SteveMathaiMD @kokopark13 @mmukherjeemd @ChrisJellisMD @rrvdpool

Meral et al found cell type-resolved #transcriptomics reveal that diastolic dysfunction is linked to a reversible shift in #fibroblast states, driven by #mineralocorticoid receptor signaling. Learn more at ahajrnls.org/4nKKJCz @MeralDavid

@CircRes May 22nd Issue is Out! ahajrnls.org/3wPOBJJ Cover: Artistic visualization of Fb state transitions, illustrating the shift from homeostatic to activated profibrotic states during HF driven by mineralocorticoid receptor signaling.

5/5 EVs-Mediated Intracardiac Crosstalk Mitigates Doxorubicin-Induced Cardiotoxicity by Wang et al bit.ly/4ujUZ7a

4/5 A Recellularized Humanized Bioengineered Bi-Atrial Model for Arrhythmia, Biological Pacemakers, and Optogenetic Studies by Ghiringhelli et al bit.ly/4a4et7R

1/5 New @CircRes podcast #DiscoverCircRes bit.ly/4tRG3fU! @StHilaireLab chats with Drs. Noah Perry and @mete_civelek about their study Female-Biased VSMC GRNs Predict MYH9 as Regulator of Fibrous Plaque Phenotype bit.ly/422Fpk3

📢 #Stroke Bridge Seminar: Normobaric Oxygen in Stroke: From Experimental Insights to Clinical Perspectives, with Ke Jian "Jim" Liu, @AneeshSinghalMD, & @Chenhsbbb. 🗓️ May 26, 12:00–1:00 PM PDT | 19:00–20:00 UTC 📎 Register: heart.zoom.us/webinar/regist…

Perry et al found #MYH9 plays a key role in shaping fibrous, more stable #atherosclerotic plaques through sex-specific regulation of #VSMCs ahajrnls.org/4wFieKD @mete_civelek @Vascular_Prot @molvascular_TUM @KaikkonenLab @InnovatieHester @DiezBenavente

Zhang et al created a set of novel reporter mouse models that precisely label #ECs, & they provide robust genetic tools to reveal the developmental origins & heterogeneity of #VECs. Learn more at ahajrnls.org/496Gyes @TheZhouLab

Wang & colleagues found cardiomyocyte-derived #EVs post exercise were enriched for a cardiac-specific protective #piRNA. Learn more about potential therapeutic strategy for #doxorubicin-induced cardiotoxicity at ahajrnls.org/3RcTaKU

Xue & colleagues identified a natural compound that blocks #RhoA, a key protein driving #HeartFailure, opening the door to new treatments that could slow or prevent the disease. Learn more at ahajrnls.org/4nub3kf

@JakubTomek13 et al found #T-World virtual #cardiomyocyte to reproduce #arrhythmia & contraction at organ scale. Learn to bring novel insights into drug-safety studies & mechanisms of arrhythmia in #diabetes & #HF ahajrnls.org/4fhfTze @JordiHeijman @jennyhelyanwe

Check out the latest review in the May 8th issue of @CircRes by Peh & colleagues "Harnessing #Immune Pathways for #Stroke Recovery: Overcoming Challenges to Clinical Translation" at ahajrnls.org/4uIGry7 @alexpehCG @DrJNoonan

Tomek & colleagues developed a virtual human #heart cell, #T-World, which enables studies on #arrhythmia mechanisms. Learn more about its validation and use at ahajrnls.org/3PfQdIT @JakubTomek13 @JordiHeijman

Ghiringhelli et al bioengineered a human-like #atrial heart model that reproduces complex #arrhythmias & can be precisely controlled with light (#optogenetics). Learn about this new platform for studying #AFib at ahajrnls.org/4tVnVCr

@CircRes May 8th Issue is Out! ahajrnls.org/3wPOBJJ Cover: Generation of a light-sensitive humanized bi-atrial model by decellularization/recellularization to study atrial reentrant arrhythmias.