Connor Finkbeiner

Excited to announce that my first, first-author paper “Single-cell ATAC-seq of fetal human retina and stem-cell-derived retinal organoids shows changing chromatin landscapes during cell fate acquisition” is out now in Cell Reports! cell.com/cell-reports/f… 1/7

First paper from our new lab! We found that invasion of peripheral immune cells into the retina make it harder for glia to regenerate neurons. @SfNJournals @InnovateUpstate @NatEyeInstitute jneurosci.org/content/early/…

🚨New #preprint alerte💡 For the first time, we show reprogramming of human Muller glia in 3D, using a novel glia/progenitor driver of proneural genes. This approach could accelerate human retina regeneration in the *near* future! 👀‼️ Check it out: biorxiv.org/content/10.110…

Thrilled to announce our last paper is out!! 🎉 Check this out 👀 ASCL1 induces neurogenesis in human Müller glia Stem Cell Reports cell.com/stem-cell-repo… Great team effort @Connorr_0 @alex_haugan @isortliz @GoldenNeuron @ThomasReh4

Our newest endeavor to regenerate neurons from glia is out now @ScienceAdvances. In this paper we try and coax Muller glia to regenerate retinal ganglion cells (Brief overview below) science.org/doi/10.1126/sc…

If you are attending @ARVOinfo this upcoming week and are curious to see what the Reh lab has been up to, please stop by and see us. Four of us will be presenting! (details below)

Very excited to share the SEACells method to identify granular metacells from single-cell data.

Finally out in Developmental Cell! authors.elsevier.com/a/1elqV5Sx5gq6… Eric Thomas @three1st_names first-authored this work which represents the awesome power of collaborative science with the groups of @realKevinEade, @SethBlackshaw, and @MelanieBahlo.

@alex_haugan Thanks! I've been meaning to do a coast road trip, I'll have to stop by. Almost everyone I knew really struggled when learning how to code. Once you get though the first year or two of learning it gets easier opens up so many opportunities!

@Connorr_0 congrats! very much well deserved and can’t wait to read it. miss seeing you in the lab everyday- now I’m having to learn how to do all the analysis you made look so easy (I can confirm it is very much NOT easy)!

Excited to announce that my first, first-author paper “Single-cell ATAC-seq of fetal human retina and stem-cell-derived retinal organoids shows changing chromatin landscapes during cell fate acquisition” is out now in Cell Reports! cell.com/cell-reports/f… 1/7

Marcus Hooper for working with me on the formative scATAC analysis, Sidnee Petter for helping stain for parts of the RGC cascade! Of course, huge thank you to @ThomasReh4 for his guidance, writing, and spending all day looking at scATAC data with me for several months! 7/7

Shout out to @isortliz for being instrumental at all stages of the process, and for learning how to work with scATAC data in R with no coding background, @akshaya_srid for teaching me a lot about how to put a paper together and doing all the organoid work 6/7

In our work out in @Cellreports we have made significant strides in regenerating neurons from glia. We find the combination of Ascl1 with Atoh-transcription factors significantly improves the ability of Muller glia to regenerate neurons. cell.com/cell-reports/f… Quick summary:

Excited to share our story in @CellReports. We looked at how microglia influence mammalian retinal regeneration. We find microglia and neuroinflammation restrict neurogenic reprogramming of mouse Muller glia. #retina #glia #microglia #regeneration cell.com/cell-reports/f…