Thomas Reh

@KiaraCEldred1 A beautiful new chapter in the CMZ story. The presence of this zone transiently in human eye development nicely extends the previous work in mice and begs further exploration in other mammalian species...

Check out our paper! We identify a population of retinal progenitors that are maintained late in human retinal development, and give rise to both first- and last-born cell types in the retina, condensing 100 days of retinal development into a small region at the retinal margin!

@M4rik0 Great work from Marina et al. This shows both the potential of the approach for translation and provides a nice platform for efficient testing if additional factors!

@J_Wohls Really outstanding study and shows the feasibility of this approach for translation to patients some day ( and even motivated me to update my twitter X account!)

🚨New #preprint alerte💡 For the first time, we show reprogramming of human Muller glia in 3D, using a novel glia/progenitor driver of proneural genes. This approach could accelerate human retina regeneration in the *near* future! 👀‼️ Check it out: biorxiv.org/content/10.110…

@J_Wohls @Levi_J_Todd @suprajagv Great work and great presentation!

I had such a blast this morning! Thank you all, it was an amazing session 🎉. #ARVO2024 @Levi_J_Todd @suprajagv

@M4rik0 Really nice work from Marina and the team!

@J_Wohls @Connorr_0 @alex_haugan @isortliz @GoldenNeuron Hats off to the amazing group, led by Dr. W!

Thrilled to announce our last paper is out!! 🎉 Check this out 👀 ASCL1 induces neurogenesis in human Müller glia Stem Cell Reports cell.com/stem-cell-repo… Great team effort @Connorr_0 @alex_haugan @isortliz @GoldenNeuron @ThomasReh4

@biorxiv_neursci Not sure I get it

Latent Epigenetic Programs in Muller Glia Contribute to Stress, Injury, and Disease Response in the Retina biorxiv.org/cgi/content/sh… #biorxiv_neursci

@Levi_J_Todd @UpstateNews @Upstate_Vision Looking forward to all the great science to come!

With a dizzying mixture of excitement, anxiousness, and gratitude, I am starting a new lab at SUNY-Upstate this Fall (@UpstateNews @Upstate_Vision). I’ll continue chipping away at the puzzles of retinal regeneration with some new twists of neuroimmunology..

@NiraulaAnzela @colgateuniv Congratulations! Wonderful how everything worked out so well. Good luck!

@SethBlackshaw @Levi_J_Todd Really nice study shows the power of collaboration!

@Levi_J_Todd @ScienceAdvances Really outstanding work by Levi, Wes and the entire group.

Our newest endeavor to regenerate neurons from glia is out now @ScienceAdvances. In this paper we try and coax Muller glia to regenerate retinal ganglion cells (Brief overview below) science.org/doi/10.1126/sc…

@mokalab1 @natcomms Fascinating

📢 Excited to share with you our paper @natcomms! Novel mechanisms: HBEGF-TNF induce in human retina organoids a complex neuropathology with photoreceptor degeneration by PIEZO1-mediated cell extrusion – potentially relevant for 👁 AMD patients & others rdcu.be/cXR54

@KiaraCEldred1 @BobbyJEyeGuy @SamerHattar Congratulations to you and all this years Fellows. Well deserved honor!

Thank you to HHMI for this amazing opportunity, I am so honored and excited to be a part of the Hanna Gray Family! Big thanks to my amazing mentors Tom Reh, @BobbyJEyeGuy, and @SamerHattar, and the rest of my scientific community for all the support!

@Connorr_0 Really great work by Connor and the team! This will hopefully open up new directions in our understanding of how cell fate acquisition is controlled in the developing retina, and gives us lots of ideas as to how to improve organoids..

Excited to announce that my first, first-author paper “Single-cell ATAC-seq of fetal human retina and stem-cell-derived retinal organoids shows changing chromatin landscapes during cell fate acquisition” is out now in Cell Reports! cell.com/cell-reports/f… 1/7

@Levi_J_Todd @CellReports Great science Levi and the team!

In our work out in @Cellreports we have made significant strides in regenerating neurons from glia. We find the combination of Ascl1 with Atoh-transcription factors significantly improves the ability of Muller glia to regenerate neurons. cell.com/cell-reports/f… Quick summary:

@LatorreLab I blame my mother, an English teacher, or else the Jesuits....

I got so much love from @ThomasReh4 when I was a postdoc 😂

The “before” photo..

Hiking in Paradise….Mr Adams in the background is next up

Perfect day on Mt Rainier!

@mokalab1 Nice!

A great collaboration of the Hackermüller lab and 🪢 MOKALAB. Many thanks to all coauthors and supporters!

📢 Out now: The latest work with our mouse retinal #organoid system 👁 All about Maturation, Growth, Stability, and Experimental reproducibility. Maintenance: 60 days in culture! Useful: Protocol for enlarged retina organoids. Manuela Völkner et al. Front. Cell Dev. Biol.