Charles Burridge

@LindorffLarsen Ile-Met-Met-Glu-Asp-Ile-Ala-Thr-Glu-Leu-Tyr!

What do we want? A protein emoji! When do we want it? Ala-Ser-Ala-Pro

I did not realize how much of my adult life would be spent thinking about protein

@Krystal4454201 @magicnetjpg @PicoPaco17 Although most de novo mutations come from the father, likely because sperm is continually being produced.

@magicnetjpg @PicoPaco17 Misleading. It is the number of DE NOVO (additional) genetic mutations. The father already has a large number of mutations from his parents, that the child will inherit regardless of the fathers age. Not to say this isn't important for disease.

In layman’s terms: If a man has a kid when he’s 30, the number of genetic mutations that kid inherits from him is about 50% higher than the number of mutations the kid would have inherited at 18 years old. Is this good or bad? While at this age the kid may group up in a more stable environment (a pro) there’s some potential cons to consider: Inheriting mutations could mean an increase the risk of health conditions, e.g., autism and schizophrenia.

@chris_waudby Fantastic news! Congratulations to both of you ❤️

✨Big news!✨ After 20 wonderful years together Stephen asked me to marry him and I said YES! We are over the moon and so excited to start this new chapter of our lives together. 🏳️‍🌈 #Engaged #LoveWins

@fesshole What is the difference between a shooty blackmarket vole and a jutey beige carpet roll? One is a mafia rat, the other is a raffia mat.

I have been carrying around the first part of a joke in my head for over a decade. It's so perfect but I just can't think of a punchline. So now I'm cursing you, too, with the set up: what's the difference between a raffia mat and a mafia rat?

@ElectoralCommUK I was "not previously aware" that my postal vote would arrive late. Is it really acceptable for my returning officer to effectively deny my vote, through no fault of my own? How is this not an "emergency" - the outcome, being denied a vote, is the same.

You can’t apply for an emergency proxy vote if you’ve registered for a postal vote. You can only apply if something prevents you from voting that you were not previously aware of - a medical emergency, being away for work, or if your voter ID is lost or stolen.

✉️ Got questions about your postal vote? Here's what you need to know ⬇️ #GeneralElection2024

@IslingtonBC I only received mine TODAY. I live in Sweden, so zero chance for it to make it in time. I was told that emergency proxy is not possible. So I just don't have the chance to vote 🤷‍♀️

If you have applied for a postal vote but still haven't received it yet, you can apply to have it reissued to you. Please call 0207 527 3110, email electoral.services@islington.gov.uk or visit Islington Town Hall, bringing your ID with you.

Thrilled to be in Tällberg again for the 27th #sweprot meeting! A really fantastic conference, with great science and scenery. Come and find me at poster 31 this evening! It wouldn't be Tällberg without a lake swim. Zoom in for evidence below 😂:

@Figlegend @proftracypalmer Seconded 👍

@proftracypalmer We routinely use the Qiagen anti-pentaHis antibody-HRP conjugate.

Any advice on his antibodies? We are struggling! Thank you

@jessphillips For now...

Why is a parent of an 18 year old responsible for a fine, they are adults.

@vimception @DmytroKrasun This approach also explains 0/0: 0 * x = 0 x can be any number.

@DmytroKrasun It's not an analogy... division and subtraction are redundant as both can be converted to an equivalent multiplication or addition. As a result, the division by zero problem does not exist as well. 5 / 0 = X is actually 0 * X = 5 Now find me an X which satisfies this.

My daughter asked today why it is impossible to divide by zero. The analogy with dividing apples for people doesn’t work anymore 😂 Do you know why, without googling?

@thebadseed2 @StorySorcery It's absolutely wild to imagine that they wouldn't announce the Kings death because of a holiday in an adjacent country.

i need british mutuals to tell me what's going over there!!! are the flags at half mast? is there a bbc blackout? is it true that bbc told everyone to be on standby for a royal announcement?

@redhistorian Maybe they need Gary Lineker...

This might be the most depressing quote about politics I've ever read. A Prime Minister rebuked for thinking like a "head of government", rather than as a "product" to be "sold", like a packet of "crisps". But it's the logic of so much political thinking thetimes.co.uk/article/rishi-…

@lewis_goodall "radicalising effect" or deradicalising effect? ;)

The Westminster (and much of the internal Conservative) conversations continues to miss everything which is driving these numbers- the quietly radicalising effect of a collapsed NHS, a broken housing market, near bankrupt local government, a still sclerotic economy.

@DavidGHFrost 'Keith Prince, transport spokesman for the Conservatives in City Hall, claimed the changes are “a wasted opportunity”. He said: “Sadiq Khan and TfL could have earned tens of millions of pounds by offering naming rights to Overground train lines.' independent.co.uk/news/uk/sadiq-…

The London tradition is that public transport lines are given a name either with a royal connection or one related to the line's geography. Giving them political names is, whether one agrees with the politics or not, a break with that tradition. It's part of the general forced politicisation of so many aspects of our daily life nowadays. Of course one would expect nothing better from @SadiqKhan and his appallingly poor management of TfL and of London.

@NoContextBrits Did the occupation of Cyprus end in 1974??

@paulmasonnews I appreciate the openness, but the first paragraph here is ridiculous. Your own perceived difficulty of the interview process and Oxbridge/Imperial science "levels of excellence"are meaningless measures of the quality of the journalism. There must be a better way to demonstrate.

When I started at Newsnight, the interview was like a PhD viva, if your PhD was about every random aspect of business and economics. They asked me to bring 10x original story ideas and ruthlessly ripped every one of them to shreds - and then said: give us another one. I had a permanent job as an editorial manager at Reed Elsevier and they offered me a 3 month contract on less money. I took it because I knew I was joining the most accomplished team of broadcast journalists in Britain, and possibly the world. I am talking levels of excellence associated with the Berlin Phil in music, or certain Oxbridge/Imperial teams in science. But the war on Newsnight's kind of journalism was already under way. And so was the technological change that ultimately allowed the disaggregation of what we were geared up to do. The big divide at the BBC was between "programmes" tailored to a specific audience, making their own editorial calls and competing on stories, versus "newsgathering", which had been designed as a sausage machine of information into the programmes. Once they decided to empower Newsgathering and disempower Programmes, which was logical in a resource strained environment, the happy upside for the top management was that they could control the news agenda, and there were fewer alternative power centres to push back. This was never a left/right split: it was a "rocking the boat versus not rocking it" split. It wasn't just NN that suffered - so did Today, so did the Ten. But NN survived because we had strong editors - and then came the Savile fiasco... there was a time, after the subsequent McAlpine disaster, when the bosses wanted to get rid of Newsnight - it survived, but only at the cost of further erosion of its autonomy and money. I left because I could feel the management tentacles gripping tighter, whatever the team did to go on knocking it out of the park. Only when I joined C4 did I finally get to see what an adequately resourced news operation should look like, and what happens when there is no invisible presence above the editor trying to shape the output, and where they don't complain about having too many reporters. But NN's demise is partly also to do with audience and technology. Once you don't have an appointment to view, there's no call for the 10-15minute reportage film; and as the rest of broadcasting has become a screaming match between extreme views, actual reason- and fact-based discussions look tame, and it suits politicians to avoid them - see their effective boycott of C4N. Also, people in the AB social bracket kept telling us: it's on too late. Professionals go to bed earlier, and the news cycle wraps earlier, so the value of a 22:30 programme diminished. Ditto because Gen Z are simply not interested in TV News. Apart from the demise of a single still excellent but struggling programme, the BBC is basically getting out of long form daily current affairs. There will be no market equivalent of NN because the market won't produce a programme like this - which was copied and emulated by every other major broadcaster. I suppose the challenge now for BBC/ITN/Sky is to resist the final erosion of OFCOM standards to the point where broadcast news becomes a far right dominated blood sport. I cannot see how moving to a late night discussion programme is going to help, especially as the open secret about far right TV is that they are paying people to turn up and be performatively outraged. At the very least they should institute a "no grifters" rule.

@nmr900 @MailOnline nature.com/articles/s4156… The actual study (which doesn't mention Sweden once!)

Covid lockdowns were NO more effective than Swedish softer approach mol.im/a/12757921 via @MailOnline

It was great to meet the other fellows and EUTOPIA-SIF team at UPF Barcelona this week. So many interesting projects!