Prof Doug Kell CBE #FBPE #FBPA🔶🇪🇺

We have written a free book (monograph) on why people believe crazy things, including #Brexit . You can download it at osf.io/pnxcs #openaccess #FBPE - please RT #beliefbook @beliefbook

@BeckyJ2779 @ConnectDots4u @janiesaysyay @xai @elonmusk @NicoVerderosa @dchaplot @dustinvtran Can you point me at these 'foundational' papers to which we allegedly give no credit (bearing in mind that we started publishing together in 2013)? Feel free to DM me.

@ConnectDots4u @dbkell @janiesaysyay @xai @elonmusk @NicoVerderosa @dchaplot @dustinvtran I do. Gerlach's work laid the foundation for those papers and received no credit. If @dbkell never heard of McCairn or the supporting networks I suspect it was more a matter of convenience for Pretorius.

Thank you 💋💋💋💋💋 @xai @ElonMusk @Nikatabier @NicoVerderosa @dchaplot @dustinvtran for over a year I have argued with Grok giving it the papers showing the SARS2 spike protein all by itself, SUI GENERIS, with or without the virus, causes amyloid fibrin #microclots. Today it successfully recalled the data!! This is a beautifully written research paper by the great @ResiaPretorius & @dbkell showing that 2021 finding. #TeamClots #TinyBubbles For more gorgeous and accurate science like this to train Grok on see: dbkgroup.org/publications/

@ConnectDots4u @BeckyJ2779 @janiesaysyay @xai @elonmusk @NicoVerderosa @dchaplot @dustinvtran Links to our papers at dbkgroup.org/longcovid/ #TeamClots

@BeckyJ2779 @dbkell @janiesaysyay @xai @elonmusk @NicoVerderosa @dchaplot @dustinvtran @BeckyJ2779 You understand that @dbkell is an author on the clotting papers with Pretorius?

@misslice @WanderingSally @CoRESinai @PutrinoLab @microbeminded2 @mcseeley @NiaALuxton @ThromBio @resiapretorius PEM: Kell, D. B. and Pretorius, E. (2022) The potential role of ischaemia-reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, long COVID and ME/CFS: evidence, mechanisms, and therapeutic implications. Biochem J. 479, 1653-1708. doi.org/10.1042/BCJ202…

@WanderingSally @CoRESinai @PutrinoLab @microbeminded2 @mcseeley @NiaALuxton And also what ever happened with this amazing-sounding discovery? How about a study looking at this in long-term LC patients with PEM, @ThromBio ??? thrombio.com.au/media/nature @resiapretorius @dbkell 😘

Australia just opened $23m in MRFF Long Covid Research Grants. $200k-$3m grants Stream 1 - $4m 2- $4m 3- $5m 4- $10m Grant docs w more recognition of LC mechanisms, complexity & heterogeneity. 🙏 grants focus on actual disease mechanisms this time! grants.gov.au/Go/Show?GoUuid…

@WanderingSally @DavidJoffe64 @misslice @CoRESinai @PutrinoLab @microbeminded2 @mcseeley @NiaALuxton @ThromBio @resiapretorius @DrRebeccaRyan Schofield, J., Abrams, S. T., Jenkins, R., Lane, S., Wang, G. and Toh, C. H. (2024) Microclots... predict risks of disseminated intravascular coagulation and mortality. Blood Adv. 8, 2499-2508. doi.org/10.1182/blooda… and dbkgroup.org/longcovid/. BIG effect.

@DavidJoffe64 @misslice @CoRESinai @PutrinoLab @microbeminded2 @mcseeley @NiaALuxton @ThromBio @resiapretorius @dbkell @DrRebeccaRyan With the testing you do - is there scope to expand it into research? Prior MRFF rounds Dr Marcel Doerflinger (WEHI) was using mouse models to investigate CNS, A/Prof Erin Howden (Baker) was looking at brain structure->autonomic dysfunction

@misslice @WanderingSally @CoRESinai @PutrinoLab @microbeminded2 @mcseeley @NiaALuxton @ThromBio @resiapretorius Schofield, J., Abrams, S. T., Jenkins, R., Lane, S., Wang, G. and Toh, C. H. (2024) Microclots, as defined by amyloid-fibrinogen aggregates, predict risks of disseminated intravascular coagulation and mortality. Blood Adv. 8, 2499-2508. doi.org/10.1182/blooda…

@WanderingSally @CoRESinai @PutrinoLab @microbeminded2 @mcseeley @NiaALuxton @ThromBio @resiapretorius @dbkell (Sepsis & LC links… yes please more please… pmc.ncbi.nlm.nih.gov/articles/PMC10…)

Madness, not yet as bad over here. theconversation.com/trumps-second-…

@KarenStrine3 @SalvMattera @ChristosArgyrop Co-morbidities actually provide huge clues to the underpinning science and are very common. Links at dbkgroup.org/longcovid/ and e.g. doi.org/10.1111/brv.12…. Many more via dbkgroup.org/publications/.

@SalvMattera @ChristosArgyrop @dbkell I’ve edited 2x b/c this is so complex. The only thing that LC should be “ coupled” with is Covid. That in itself is a problem b/c few test to know to prevent more LC. Have you researched any nonprofits for grants to raise awareness?

The philosopher of science, Karl Popper, has been one of the biggest influences on my thinking. You might not know who he is, but I guarantee his ideas have impacted your life in some way. When it comes to COVID, two of his concepts seem especially relevant: 1. Falsifiability - it was Popper who wrote that in order for something to be considered science, it must be falsifiable. Unfortunately, most "Long COVID science" doesn't meet this bar. I'm not talking about alternative medicine, but the actual studies masquerading as science. Take, for example, the recent fluvoxamine trial, which claimed to test the hypothesis that the SSRI could benefit people with Long COVID by reducing inflammation in the nervous system. But the study was designed in such a way that nothing relevant was measured - regardless of the result, the study was never capable of falsifying the hypothesis it supposedly set out to test. Or, take the lumbrokinase trial they're currently recruiting for. It supposedly tests the microclot hypothesis, yet the study doesn't measure anything having to do with microclots. No matter what happens, the microclot hypothesis cannot be disproven by the study. If the drug works, it could be placebo effect. If it doesn't work, maybe it was the wrong dose, the wrong group of patients or the wrong duration. Nothing will be falsified, and so nothing will change. A recent vagus nerve stimulation trial stimulated a nerve for 4 weeks and measured whether patients felt less tired. They never verified the nerve was actually being stimulated. No heart rate variability was checked. No inflammatory markers of any kind were measured. How can you falsify "vagus nerve stimulation helps Long COVID" if you never confirmed the vagus nerve was even stimulated in the first place? The answer is you can't. Popper would reject all of these studies. Not because the hypotheses are wrong (they may be right), but because the trials, as currently designed, aren't science. They're theater. 2. Now, here's where Popper's other idea comes in, and it connects directly to the political environment around Long COVID that determines which trials get funded: his notion of "Historicism" - the idea that history moves in a predictable pattern. Most people subscribe to some form of historicism, even if they can't articulate it. Liberals, for example, often think that, over the arc of time, history bends towards justice. But the truth is that it doesn't. You don't have to study history for very long to see that this idea is pure nonsense. History is unpredictable. It moves in both directions: Iranian women had more rights in 1975 than they do today. Afghan girls attended school for twenty years until they couldn't. Weimar Germany was the most progressive democracy in Europe before it produced the Nazis. Roe was settled law for fifty years until it wasn't. So when someone tells you "awareness is growing" and "research is progressing" and "eventually we'll find treatments" you should ask: who specifically is making that happen, by when, and what happens if they fail? Unless they can tell you that, then this is just historicism. The idea of historicism also applies more generally to people's attitudes towards the pandemic, and what the future has in store for us all. Early on, we saw pandemic deniers practice a form of historicism - "Pandemics come and go. Humanity survives. This is just another flu." In other words, history moves in a pattern. The pattern is everything, and it is inevitable. But I've seen other versions of this, as well. Take Iwasaki's "Lingering Shadow of Epidemics" paper, which documents how post-viral illnesses have followed every major pandemic for the last 100+ years. On the surface this seems helpful. But think about what the framing actually does. It recasts COVID and Long COVID from an urgent emergency that must be solved to just the latest permutation in a long, historical pattern. When it's a historical pattern, no one is responsible because this was always going to happen. But if Popper was still alive, he would say this is nonsense. We don't know the future. History doesn't repeat in predictable ways. One pandemic is never exactly like the last. Post-polio syndrome disabled people decades after they thought they had successfully recovered from their polio infection. Nobody saw it coming during the acute polio era. We still don't really understand it. EBV sits in your body for 20 years before it triggers MS in some people. The latency period spans a full generation. Think about what we've done with COVID. We have infected billions of people, multiple times, with a neurotropic virus that crosses the blood-brain barrier, causes vascular damage, and persists in tissue. We have six years of data. Anyone who tells you they know what this looks like 20 years from now is lying to you. There is no "shadow" of this pandemic - this pandemic is still ongoing. 20 years from now, maybe nothing will happen. Or maybe large numbers of people will develop serious neurological diseases. We have no idea, and we're not even trying to stop it. The future is open. People are making choices right now about funding, research priorities, and accountability that will determine whether millions of people get treatments or get abandoned. Those choices are, and have been made, by specific people with names. Not by history, patterns, or "lingering shadows." Stop telling me this "isn't new". Instead, tell me who is going to fix it, by when, and what happens to them if they don't.

@SalvMattera INSTEAD OF BLASTING BACK A NON-REPLY I SUGGEST YOU GO AND READ HIS WORKS FIRST

ME/CFS "coheres" with POTS which "coheres" with MCAS which "coheres" with EDS. The whole diagnostic framework is built on coherence: everything fits together, everything supports everything else, it's a beautifully coherent system. And it produces zero treatments and millions of sick people

@BBCr4today @amolrajan @BBCSounds Utter tosh. @BBCNews should be embarrassed but won't be because they are told a Govt li(n)e to take.

“We're finding problems in milder and milder forms.” Dr Suzanne O’Sullivan, author of 'The Age of Diagnosis', says we are over-detecting diseases in some people that may never have been harmful. Listen to Radical with @amolrajan on @BBCSounds

@DavidJoffe64 @ZdenekVrozina Extensive and self-consistent evidence summarised at dbkgroup.org/longcovid/.

@ZdenekVrozina 🙏🏻 Despite the evidence of mTOR I've had little joy with treating the tinnitus. @dbkell has proposed micro-clotting as a pathway. Presumably, like all things Cøvid, it's probably multifactorial

@archer_rs @Vicgoch The billionaires who caused it, obvs (and some of their puppet grifters masquerading as politicians).

It's very telling that any post critical of Brexit almost instantly receives a large number of bot replies attempting to discredit it. Someone is very invested in pretending Brexit is anything other than a complete disaster and that EU Rejoin is inevitable.

@BBCr4today @amolrajan @BBCSounds Please stop platforming this woman. Why don’t you speak to those doctors and scientists with *actual” expertise in long COVID, POTS, ADHD, autism & the other non-psychosomtic conditions this woman doesn’t have the first clue about and then you might realise the level of damage 1/

🇬🇧NHS staff are boycotting Palantir. But the UK gov keeps signing new Palantir contracts while promising tech sovereignty. The UK paid Palantir £330 million in 2023 to build the NHS Federated Data Platform. But NHS staff are refusing to use it because of important concerns: > Palantir's close relationship with the US government > Its recent work with ICE on Trump's deportation operations > Privacy concerns over who ultimately controls NHS patient data Growing NHS staff resistance against Palantir Clinical and non-clinical workers are deliberately slowing their work pace when forced to log in. One official called Palantir "ethically bankrupt." (see article below) Even the British Medical Association has called on doctors to stop using it entirely. 🇬🇧 UK government contradictions on tech sovereignty But the UK government, which previously committed to greater tech sovereignty, just signed a new data contract with Palantir through the Ministry of Defence. And the Financial Conduct Authority quietly added a 3 months Palantir trial contract last week. My takeaway from that story is that NHS employees are more committed to tech sovereignty and privacy than their government. That's sad, but there's hope in it!

Walk the Walk MAGA!