Dr.Fernandezcar

It is an honor to contribute to this study. In anti-NMDAR encephalitis with prolonged disorders of consciousness (≥9 months) ▶️about two-thirds achieved substantial or full recovery over long-term follow-up. ▶️Older age and higher NEOS scores increase mortality 🧠👌

Privileged to contribute to research on NMDA encephalitis with prolonged disorders of consciousness.👌

Remote attendance at the outstanding Neuroimmunology & Autoimmune Neurology course by Clinic Barcelona. Insightful discussions on stiff-person syndrome, autoimmune encephalitis, and anti-IgLON5 disease. #Neuroimmunology #AutoimmuneNeurology #IgLON5 #StiffPersonSyndrome

⚡New #PNS study! In a population-based cohort of 878 patients evaluated for suspected @paraneoplastic syndromes, alternative diagnoses were common, especially in patients <55 and those without high-risk syndromes. The PNS DDx Score was developed⬇️ 👉 : link.springer.com/article/10.100…

This constitutes a significant diagnostic challenge, particularly in neuromuscular disorders, where many paraneoplastic phenotypes are non-classical and often overlap with other neurological conditions.

Always important to see what our rheumatology colleagues are doing:👇🏽 Here on inhibitory checkpoints in autoimmune disease. TIGIT is particularly interesting, as it inhibits effector T-cell function while also promoting Treg activity. Nice review in @NaturePortfolio on the field!

Chiaro et al. describe the long-term natural history of a cohort of patients with isolated autonomic failure, and validate a predictive model to help identify patients at risk of phenoconversion to more widespread synucleinopathy. doi.org/10.1093/brain/…; shorturl.at/0rZhc

▶️When after-discharges follow the CMAP and the F-wave is unrecognizable, Morvan syndrome is the most likely diagnosis. 👌🧠

▶️Anti-Ma2 antibodies are not exclusively paraneoplastic, as nearly 30 % had no detectable cancer ▶️ Idiopatic Ma2 cases showed a slower, more insidious onset. ▶️MRI and CSF inflammatory findings did not differ, while EEG abnormalities were more frequent in I-Ma2.

▶️Morvan syndrome is an autoimmune peripheral nerve hyperexcitability disorder. ▶️It features neuromyotonia, autonomic dysfunction, and severe insomnia. •It involves both the PNS and CNS. •Strongly associated with CASPR2 (± LGI1) antibodies and sometimes thymoma.

6. Autonomic and respiratory dysfunction NMDARs in the preBötzinger complex and nucleus of the solitary tract (NTS) participate in respiratory rhythm generation and baroreceptor reflexes🧠👌👍

3.Alteration of fronto-temporo-hippocampal networks disrupts cognitive inhibition. 4. Reduction of NMDARs in GABAergic interneurons causes loss of gamma oscillations and global desynchronization, contributing to psychotic symptoms and epileptic seizures. ⏬️⏬️⏬️

NMDAR 👌 1.The alteration of long-term potentiation at CA3–CA1 synapses leads to episodic amnesia and difficulties in learning and working memory. 2.Dysfunction of pyramidal neurons and parvalbumin-positive interneurons results in deficits in working memory, and e. functions ⏬️

5. Sleep NMDARs in GABAergic neurons of the lateral preoptic area regulate NREM sleep. Their dysfunction → severe insomnia during the acute phase. The REM pattern and sleep consolidation are also altered.⏬️⏬️⏬️.

▶️This study identifies painful amaurosis fugax as a rare prodrome of optic neuritis in MOGAD. ▶️In 2.3% of patients, brief painful visual loss (median 15 minutes) preceded optic neuritis within days. 🧠👌

Proud to present at ECTRIMS 2025 We are honored to present our poster “Impact of McDonald 2024 Criteria on Early Diagnosis of MS in a Chilean Cohort with Clinically and Radiologically Isolated Syndromes” at ECTRIMS 2025 in Barcelona. With @jeipimansilla 🧠

We are here to continue learning about this fascinating and challenging disease.

Unique PSG finding in anti-Ma2 encephalitis: extreme REM predominance with recurrent SOREMPs, indicating secondary narcolepsy from hypothalamic dysfunction. A novel pattern not previously reported in autoimmune encephalitis. 🧠👌 neurology.org/doi/pdfdirect/…

@Owaimoh5584 Súper🙏 Is there anything we can do to support you?

@DFernandezcar Subject: Request for EEG/MRI Data Dear Researchers, I am a student working on a graduation project about autoimmune encephalitis and kindly request related EEG or MRI data for research purposes only. Thank you.

▶️Anti-LGI1 encephalitis causes lasting white matter network changes.These changes relate to persistent cognitive deficits. ▶️Impairments affect memory, attention, and executive function. ▶️They persist despite immunotherapy. LGI1-E is a global network disorder, not just limbic.