Digital Health and Patient Safety Platform

Impacts of biomedical hashtag-based Twitter campaign: #DHPSP utilization for promotion of open innovation in digital health, patient safety, and personalized medicine digitalpatientsafety.com/impacts-of-bio… #DigitalHealth #PatientSafety #PersonalizedMedicine #HospitalsTalkToLovedOnes

@_atanas_ “Acute sleep rebound following sleep restriction is associated with reduced mortality risk.” Published April 27, 2026, Nature Communications nature.com/articles/s4146…

Catch-up sleep after sleep restriction was linked to lower mortality.

“GH001 vs Placebo in Patients With Treatment-Resistant Depression: A Randomized Clinical Trial.” Published March 25, 2026, JAMA Psychiatry jamanetwork.com/journals/jamap…

Ultra-processed foods, lifestyle management, and cardiovascular diseases: A clinical consensus statement of the European Society of Cardiology Council for Cardiology Practice and the European Association of Preventive Cardiology of the European Society of Cardiology academic.oup.com/eurheartj/adva…

Clock and the Cleaner: Circadian Rhythms and Autophagy Coupling in Alzheimer's Disease "In early-stage AD, circadian rhythms show mild disruption and autophagy initiation remains active, but downstream autophagosome-lysosome fusion and lysosomal degradation are impaired, leading to the accumulation of AD pathological proteins..." "...In late-stage AD, severe circadian disruption likely uncouples circadian control from autophagy, and these dysfunctions mutually exacerbate each other, driving neuroinflammation, neuronal dysfunction, and further accumulation of pathological proteins..." [At early stage, "dysregulation is cell-type-specific: neuronal clocks remain relatively intact, whereas astrocytic and microglial clocks exhibit altered metabolic and immune rhythms"] aginganddisease.org/EN/10.14336/AD…

Marlboro maker accused of ‘exploiting’ young people with new global ad campaign. Philip Morris claimed it wanted to end cigarette sales, but experts and campaigners say new promotions seem designed to attract younger consumers. theguardian.com/society/2026/m…

Time’s almost up giving now can still make a big difference. I’ve shared it. #healthcareIT #eHealth #healthcare #digitalhealth

From repair to disease: lymphatic contributions to regeneration, cancer and ageing "...Lymphatic vessel dysregulation drives aging and age-associated diseases, highlighting an urgent frontier for intervention...." sciencedirect.com/science/articl…

Association between mushroom consumption and digit span performance among middle-aged and older community-dwelling Japanese: the NILS-LSA project pubs.rsc.org/en/content/art…

Why isn’t #alcohol seen as a public health emergency? Alcohol kills more Americans than any other drug by a wide margin. But discussions about substance use #epidemics in the U.S. are usually centered around drugs like fentanyl or meth. In fact, most people in the U.S. do not see alcohol is as much of a public health problem at all. statnews.com/2026/05/15/alc…

Sleep Disorders Reshape the Cardiovascular Risk Prediction Value of Systemic Inflammation: A NHANES Cohort Study (2005-2018) Highlights ▶️ Sleep disorder (SD) is a powerful, independent risk factor for cardiovascular mortality, rivaling the risk of established cardiovascular disease (CVD). ▶️ Baseline systemic inflammation does not mediate the SD-CVD mortality link, challenging a prevailing hypothesis. ▶️ SD acts as a key effect modifier, nullifying the predictive value of inflammatory markers for new-onset CVD. ▶️ The SD-inflammation interplay is strongest in high-risk subgroups: former smokers and the physically inactive. ▶️ Findings advocate for integrating sleep health into metabolic and cardiovascular risk assessment frameworks. nmcd-journal.com/article/S0939-… @HealthyFellow

Exercise and the Gut Microbiome: From Mechanisms to Clinical Applications ✅️ Exercise can modify gut microbiota composition and function independently of diet. ✅️ Exercise effects are intensity-dependent, transient, and reversible. Moderate-intensity continuous training reliably increases microbial diversity, enriches health-associated taxa (Akkermansia, Faecalibacterium, Roseburia), and enhances intestinal barrier function. High-intensity interval training acutely perturbs the ecosystem but, following adaptation, stimulates butyrate production through lactate cross-feeding. mdpi.com/2072-6643/18/1… @HealthyFellow @tatiann69922625 @Mangan150 @_atanas_ Schematic representation of exercise-induced immunomodulation of the intestinal barrier. Moderate-intensity exercise upregulates tight junction proteins (claudin-1, occludin, ZO-1), reduces pro-inflammatory cytokine expression (TNF-α, IL-1β, IL-6), & increases anti-inflammatory mediators (IL-10, TGF-β). These adaptations limit bacterial lipopolysaccharide (LPS) translocation & attenuate systemic metabolic endotoxemia.

@_MCRicardo_ Reductionist nutrition failed because humans do not metabolize isolated compounds

Early-onset colorectal cancer was linked to epigenetic fingerprints of pesticide exposure.

Seven Years of 700 Cholesterol Without Coronary Atherosclerosis: A Lean Mass Hyper-Responder Case Report This @nicknorwitz article is buzzing on social well beyond longevity circles. Let this forum be where the constructive debate begins. mdpi.com/2079-9721/14/5… @Diseases_MDPI

This is a timely and important focus. Linking air pollution with chronic respiratory diseases and broader NCDs highlights exactly the kind of multisectoral action needed.

New urine test for lung 🫁 health? Scientists have developed an injectable nanoprobe that detects therapy-induced cellular senescence and pC- simply by peeing in a cup. The probe releases gold nanoclusters when cut by MMP-7, an enzyme elevated in senescent lung #cancer cells and fibrotic tissue. These tiny clusters pass into urine, where a simple colorimetric assay reveals disease activity. In mouse models, the test tracked chemotherapy-induced senescence, monitored senolytic drug effects, and spotted early #lung fibrosis - noninvasively and longitudinally. nature.com/articles/s4358…

A Multiomics Framework to Unlock the Relationships between Wine, Food, and Gut Health ▶️ This review explores current evidence regarding the impact of moderate wine consumption on human health, w/a focus on its interactions w/gut physiology & metabolism. It provides an innovative framework, leveraging advancements in multiomics to enable research to decipher the understudied interplay between wine’s bioactive compounds, food matrices, gut functions, & health. sciencedirect.com/science/articl… @HealthyFellow @drfherediaz @DrKristieLeong @Mangan150 @DrRPalmquist @_atanas_ @LoriShemek @tatiann69922625 @louisanicola_ @DrGrimaldesJ There is a growing interest in wine and health research across the major physiological systems, including the gastrointestinal tract. (A) Tree map highlighting publication numbers for the search terms “wine AND” [the major physiological system], including the gastrointestinal tract with 105 articles related to microbiota (refer to Supplemental Table 1). (B) An illustration of a trend in publications reporting on wine and the gut compared with wine and the cardiovascular system. Data shown are the number of research articles on PubMed using the search terms “wine AND cardiovascular” and “wine AND gut” between 1957 and 2025. (C) A proposed multiomics framework to decipher molecularly defined 3-way relationships among wine, food, and gut health.

Obesity has risen in all countries - but at a faster pace in poorer ones. New global study of 232 million people reveals a dramatic split in the #obesity epidemic: In high-income Western countries, the rise in obesity has plateaued or even begun to reverse, especially among children, with countries like Japan, France, and Denmark stabilizing at low prevalence levels (3–6%). But in most low- and middle-income nations, obesity is accelerating faster than ever, with 2024 velocities hitting record highs across Asia, Africa, Latin America, and the Pacific Islands. The study, analyzing four decades of data from 200 countries, shows that while some wealthier nations have curbed the rise (likely due to food policies, social norms, and health awareness), developing regions are seeing obesity surge - even where prevalence already exceeds wealthy countries. nature.com/articles/s4158…

Breaking the nap habit: one-year nap restriction mitigates memory decline in older adults 🤔"suggest that targeted nap reduction may offer an accessible strategy to mitigate age-related decline in specific cognitive domains, regardless of whether habitual napping represents a causal or compensatory factor of neurobiological vulnerability." link.springer.com/article/10.100…