Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM

Honored to be named among the Top 10 emerging voices in longevity by @StoryfulNews! Proud to be listed with such a dynamic and thoughtful group—including @mkaeberlein, @CharlesMBrenner, and Rhonda Patrick @foundmyfitness—for helping shape science-driven longevity conversations🚀

Hallmarks of healthy cognitive aging: inter-individual differences in aging trajectories sciencedirect.com/science/articl…

Some of these associations may represent confounding by other variables, while the association with skin cancer is incontrovertible. The case for nitric oxide production may be most compelling. Research on additional potential mechanisms is ongoing. Best to consult with your provider.

Sunlight: Time for a Rethink? 🤔 “Growing evidence shows that sunlight has health benefits through vitamin D–independent pathways, such as photomobilization of nitric oxide from cutaneous stores with reduction in cardiovascular morbidity. Sunlight has important systemic health benefit as well as risks.” jidonline.org/article/S0022-…

Translational toolkit for reproducible, cross-study profiling of human ageing hallmarks in human blood and tissue "This integrated platform provides a foundation for reproducible, cross-study analyses and facilitates translational investigation of interventions targeting health-span extension." biorxiv.org/content/10.648…

Cellular Senescence in Skeletal Muscle Aging e-enm.org/journal/view.p…

PhD Thesis idea: how #PFOS and other environmental contaminants interfere with glucagon receptor signaling? #Exposome

Healthy lifestyles and survival beyond age 100: Evidence from a national cohort of Chinese centenarians maturitas.org/article/S0378-…

Communication breakdown: senescent cells in interorgan communication of aging cell.com/trends/endocri…

@NirBarzilaiMD After all these years, a great mentor to many, at all stages of their career. 🌟

@NirBarzilaiMD Congratulations, Nir!

I am honored to announce I have received AFAR’s 2026 George M. Martin Lifetime Achievement in Mentoring Award, named after AFAR’s Scientific Director Emeritus. Learn more about this award here: afar.org/george-m-marti…

Acarbose modulates microglial Pkm2 acetylation to reshape immunometabolism and preserve retinal neurons after ischemia-reperfusion 👉"Our findings support that ACA exerts retinal protection through the Sirt1-Pkm2-NAD axis, suggesting a metabolic checkpoint that integrates immune and mitochondrial regulation." link.springer.com/article/10.118…

The need to increase support for healthy ageing and longevity research in the EU by establishing a Coordination and Support Programme on Healthy Ageing and Longevity 🌟This paper calls for the establishment of an EU Coordination and Support Programme on Healthy Ageing and Longevity to integrate research, innovation, regulation, and capacity‑building across Member States, as a strategic priority for health, innovation and sustainability. 🔗sciencedirect.com/science/articl… h/t @ILAISRLA, @Rcmsiow, Efstathios Gonos, and colleagues.

Polyamines as a Universal Language of Host-Microbiota Symbiosis spj.science.org/doi/10.34133/r…?

Interventions for promoting physical activity and reducing sedentary time among people aged 55 years and older: an overview of systematic reviews "Consistent evidence suggests that technology-based interventions are effective in increasing physical activity, step counts and MVPA, whereas inconsistent findings support the effectiveness of exercise and behavioural interventions in increasing physical activity." academic.oup.com/ageing/article…

Blood flow and angiogenesis: Major mechanisms mediating healthful longevity sciencedirect.com/science/articl…

Serum Klotho Levels, Brain Structure, and Cognitive Performance "Results suggest that circulating serum klotho levels modified the known adverse association between age-related brain atrophy and cognition in older, but not younger, adults at risk for AD, suggesting that the neuroprotective effects of klotho may be age dependent." jamanetwork.com/journals/jaman…

Toward actionable interventions in human aging (12th ARDD meeting, 2025) aging-us.com/article/206368… @AgingJrnl

The mitochondrial side of frailty "Mitochondrial dysfunction lies at the intersection of musculoskeletal, metabolic, and immune changes underpinning frailty. While integrative biomarker panels have defined metabolic signatures, early diagnosis and personalized therapies remain unmet needs. Longitudinal studies are required to establish causality, refine biomarker utility, and guide precision medicine strategies to preserve mitochondrial function, extend healthspan, and improve quality of life in aging populations." journals.lww.com/co-clinicalnut…

@bryan_johnson By blood, sweat, and tears… and other biomarkers 😁 Congratulations Bryan 🌟

18 years of effort to reach 1M followers on X. Was it worth it? > 116 days time spent > 16,686 posts > guessing 10 min per post > 793,070 replies > first 500K, 16 yrs > second 500K, 2 yrs