Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM

Honored to join the faculty for MVMNT, a longevity medicine summit built the way the field needs: evidence first, and the discipline to say what works, what's promising, and what's premature. 🩺 Sept 22-23, 2026 | Coronado, CA | @VituityHealth 🔗theemvmnt.com

Ribonuclease DIS3 delays aging and senescence by generating tRNA halves nature.com/articles/s4146…

How Long Can Elon Live, and Stay Productive? The richest, most capable builder alive has maximal access to everything money can buy, extraordinary IQ, and omnipotent AI. What do you think @elonmusk? forever.ai/p/how-long-can…

Autonomous biomedical research with an artificial intelligence agent “ We introduce Biomni, a general-purpose biomedical artificial intelligence agent… Biomni envisions artificial intelligence augmenting human scientists and accelerating discovery.“ 🤖 science.org/doi/10.1126/sc…

The Longevity-Relevance Paradox Why Living to 100 Doesn’t Guarantee Staying Employable Past 40 futuristthomasfrey.substack.com/p/the-longevit…

Mitochondria transfer in neurological disorders: the key role of neuroglia This review critically examines mitochondria transfer in neurological diseases, with a focus on glial contribution and underlying mechanisms, and outlines key challenges and opportunities for advancing both mechanistic understanding and therapeutic translation. …arneurodegeneration.biomedcentral.com/articles/10.11…

Lawnmower-like Enzyme Rewinds Decades of Molecular Aging in Human Tissue An engineered enzyme cleaved and repaired age-related protein damage in human tissue, which was long thought to be irreversible in a proof-of-concept study. the-scientist.com/lawnmower-like… @newscientist

Comparative effects of drugs for adults with overweight or obesity: systematic review and network meta-analysis ☹️ "Most agents do not improve quality of life meaningfully and few show cardiovascular benefits." 📊 "Obesity drugs produce variable weight loss at one year, with larger benefits generally accompanied by greater harms and discontinuation." Read, and share your own interpretation and conclusions.👨‍⚕️ bmj.com/content/394/bm…?

Low cardiorespiratory fitness was associated with a fivefold higher risk of death compared with elite fitness (adjusted HR 5.04), far greater than the risks linked to: - Coronary artery disease (1.29) - Smoking (1.41) -Diabetes (1.40).

Associations of Life's Essential 8 With Mortality Among Individuals With Diabetes and/or Hypertension: Statistical Mediation by Inflammation and Biological Aging "Higher LE8 scores are associated with reduced mortality risk in individuals with diabetes and/or hypertension, with inflammation and biological aging statistically mediating these associations in an exploratory manner... but causal interpretation requires further longitudinal studies." pubmed.ncbi.nlm.nih.gov/42179110/

Observational data, but intriguing. 🧐

If your dog is overweight, under vet supervision, a mild caloric deficit and this protocol may be best: A doggy 🐶 biohacking protocol: Once-daily feeding is associated with better health in companion dogs: results from the Dog Aging Project

Public service announcement: Please do not put your dog on 72 hour fasts.

Energy beats: Daily and circadian rhythms in mitochondrial biology sciencedirect.com/science/articl…

Chai Discovery, an A.I. Drug Start-Up, Raises $400 Million The fund-raising values the company at $3.8 billion and underscores investor interest in using artificial intelligence to tackle problems like drug discovery. @jackdent @chaidiscovery 🔗nytimes.com/2026/07/14/bus…

Viagra for Life Extension Does it work? I'm doubtful By @cremieuxrecueil 🔗cremieux.xyz/p/viagra-for-l…

Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain "These findings demonstrate that targeting cellular senescence at an early stage can mitigate degenerative changes and pain, supporting senolytic therapy as a promising preventive strategy for musculoskeletal decline." advanced.onlinelibrary.wiley.com/doi/10.1002/ad…

Bat-Inspired Longevity: Immune Damage Management and Nutritional Modulation for Healthy Aging mdpi.com/1422-0067/27/1…

Exercise hormone irisin alleviates rheumatoid arthritis by removing dysfunctional mitochondria "Our study elucidated the underlying mechanism through which exercise alleviated experimental arthritis and offered a feasible therapeutic strategy for RA." tandfonline.com/doi/10.1080/15…

Longevity Fight Club rules: 1) zone 2 cardio 2) you MUST talk about zone 2 cardio 3) fights decided by VO2 max, no punch thrown since 2019 4) Kevin, for the last time, we are not cycling testosterone. 👨‍⚕️