Daniel Jost

404 posts

Daniel Jost

Daniel Jost

@djost_physbiol

@CNRS Senior Researcher - Group Leader at @Lyon_LBMC, @ENSdeLyon. Physical biology of chromatin: modeling the spatio-temporal dynamics of eukaryotic genomes

Lyon, France Katılım Aralık 2016
385 Takip Edilen692 Takipçiler
Daniel Jost
Daniel Jost@djost_physbiol·
Dear All, That would be my last message on X for obvious reasons. Freedom of speech is not the freedom to say anything or to discriminate. I migrate to Bluesky @djost-physbiol. For the french community, a great tool to facilitate the migration app.helloquitx.com !
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Flora Paldi
Flora Paldi@flora_paldi·
Huge thanks to all co-authors on this manuscript for their fantastic work @MF_Szalay, @MarcDiEsse, @djost_physbiol, Hadrien and Giacomo! Special thanks to dear colleagues, especially @i_jerko, and of course the one and only @PierreRome for the infinite support ❤️
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Daniel Jost
Daniel Jost@djost_physbiol·
Stay tuned: more to come from our side with a genome-wide analysis/modeling of the consequences of replication-mediated loop extrusion in yeast with new experimental data, hopefully posted in the coming weeks
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Daniel Jost
Daniel Jost@djost_physbiol·
Our paper on modeling DNA replication and its consequences on 3D genome is finally out in @PhysRevX, tinyurl.com/3exv49tt : Replication machinery may act as a transient loop extruder ! Congrats to Dario and the team !! @CNRS @Lyon_LBMC @ENSdeLyon
Daniel Jost@djost_physbiol

Very proud of our new preprint on the coupling between DNA replication and 3D genome using polymer modeling and data analysis. shorturl.at/hsAVZ We provide strong evidence that the replication machinery may act as a loop extruder on chromatin ! Check the tweetorial 👇

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Daniel Jost
Daniel Jost@djost_physbiol·
Very happy to have collaborated with @aurelepiazza to investigate loop extrusion in vivo. Very rich datasets to investigate the regulation of condensing road blocks and processivity along the cell cycle. Check the preprint and the post !
Aurèle Piazza@aurelepiazza

How do specific communications arise in chromatin? Here we determine condensin’s loop extrusion properties in budding yeast and identify various types of roadblock. It makes a conditional loop that allows mating-type switching to take place. biorxiv.org/content/10.110…

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Anton Goloborodko @golobor@bsky.social
Anton Goloborodko @[email protected]@golobor·
A big thank you to ERC for selecting my lab for one of this year’s starting grants! This award will enable us to explore the molecular mechanisms of DNA homology search using computational 3D genome models.
IMBA imbavienna.bsky.social@IMBA_Vienna

Anton Goloborodko (@golobor), Group Leader at IMBA, was awarded a Starting Grant from the @ERC_Research for his research on homology search in DNA repair. Congratulations! #ERCStG More information: bit.ly/47l2lNh Our recent interview with Anton: bit.ly/4d18akA

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Irene Farabella
Irene Farabella@iosonoirene·
Our lab is on the lookout for curious and creative PhD candidates as part of the @RNA_iit. Don't miss out - there's still time to apply! @semm_it @IITalk #compbio
RNA Flagship at IIT@RNA_iit

Applications are open for the PhD program @IITalk with @semm_it Several positions available Key dates: CALL CLOSING 12 September 2024 EXAMINATION DAYS 23-26 September 2024 OFFICIAL STARTING DATE 1 November 2024 semm.it/positions-avai… pls RT

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Elphege Nora Lab at UCSF
Elphege Nora Lab at UCSF@ElphegeNoraLab·
Our department of Biochemistry and Biophysics at the University of California San Francisco is recruiting tenure-track faculty aprecruit.ucsf.edu/JPF05209 We welcome all areas of biology across models - from single molecules to organisms and ecosystems. Deadline Oct 15 2024 Pls RT
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Daniel Jost
Daniel Jost@djost_physbiol·
Very happy to have contributed to this fantastic work by @aurelepiazza group! A new technique (HiC for ssDNA), new insights into DNA homology search, and a little bit of modeling, of course 😉. Congrats to all the team !
Aurèle Piazza@aurelepiazza

How do you find a needle in a genomic haystack? Yeast yields some answers here, thanks to Xless Agnès Dumont, Nicolas Mendiboure, @JSavocco, @djost_physbiol et al. Free here for 50 days, or very similar preprint here: x.com/aurelepiazza/s… Enjoy!

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Ivana Jerković
Ivana Jerković@i_jerko·
Ever wondered how 3D chromatin rewires during differentiation? We wanted to understand this process better & distinguish if different processes or elements drive this rewiring. To do so, we used mESC=>NPC differentiation and focused on a single locus. biorxiv.org/content/10.110… 1/17
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Daniel Jost
Daniel Jost@djost_physbiol·
A lot of fun applications to come !!
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Daniel Jost
Daniel Jost@djost_physbiol·
New preprint from the lab ! This is a long-term collaboration with my colleague Gaël Yvert @Lyon_LBMC on the kinetic characterization of an optogenetic tool his group developed to control Cre-mediated recombination in vivo. Experiments + modeling. biorxiv.org/content/10.110…
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Aurèle Piazza
Aurèle Piazza@aurelepiazza·
To all INSERM engineers in bioinformatics seeking to change air: we are hiring by mean of internal mobility! I can't stress enough how friendly the atmosphere is in the department, the ENS and in Lyon. It's a great opportunity! Offer here: t.ly/BkGiw
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Gene Regulation
Gene Regulation@generegulation·
Are you a member of the Biophysical Society? Do you work on DNA-protein binding, chromatin, gene regulation? Please join the Biophysical Society's subgroup Multiscale Genome Organisation. We are 10 members short of the threshold required to keep this group biophysics.org/subgroups/mult…
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Keşfet

@djost @MF_Szalay @MarcDiEsse @i_jerko @PierreRome @CNRS @CNRS_dr07 @Inserm