Dimitri Sidiropoulos

In response to the call for commentaries on how to fulfill the goals of #AACR26 and advance cancer science to save lives globally: The Seven Ps of Cancer Interception doi.org/10.1158/2159-8… By Dimitrios Sidiropoulos, @NeehaZaidi, @MarkYarchoan, and @DrLizJaffee

Looking forward to the @AACR Annual Meeting themed “Precision, Partnership, Purpose: Advancing Cancer Science to Save Lives Globally.” In @CD_AACR, we outline the 7 Ps of Cancer Interception, a unifying lens for achieving this mission. aacrjournals.org/cancerdiscover… See you at #AACR26!

New perspective aligned with the mission of upcoming #AACR26 meeting (one of a series in @CD_AACR) The Seven Ps of Cancer Interception purpose prevalence potential precision practicality partnership persistence aacrjournals.org/cancerdiscover… @DNSidiropoulos @NeehaZaidi @DrLizJaffee

Now online: B Cells and Tertiary Lymphoid Structures as Integral Components of the Cancer Immunity Cycle doi.org/10.1158/2326-6…

Our phase I study tested binimetinib (BINI, MEK inhibitor) + hydroxychloroquine (HCQ, autophagy inhibitor) in KRAS‑mutant, previously treated metastatic pancreatic cancer. Rationale: dual MEK + autophagy inhibition ➡️ therapeutic synergy in PDAC models (as shown by @cjder23) @DrShubhamPant @Fen_Saj @OncJournal academic.oup.com/oncolo/article…

Excited to share our latest preprint-- "Monocytes are biological sensors of aging and frailty in humans" biorxiv.org/content/10.648… @INBT_JHU @JHUBME @HopkinsEngineer @FrailtyScience

⭐ EXCLUSIVE: A new public immune atlas of #PancreaticCancer therapy responses by researchers @hopkinskimmel @HopkinsMedicine allows the public to rapidly link PDAC #immunotherapy trials to immune shifts/outcomes. 📹 To learn more, watch the full video: hubs.li/Q0460nJS0

@madamscientist @TargetedOnc @andrea_elea Thanks Rajini!

@DNSidiropoulos @TargetedOnc @andrea_elea Congrats, Dimitri!

thank you @TargetedOnc @andrea_elea for highlighting our work!

⭐ In this latest feature, we spotlight the work of @HopkinsMedicine @hopkinskimmel's Drs Won Jin Ho @wonjinho1 and Dimitri Sidiropoulos @DNSidiropoulos — a public cytometric atlas to drive next-gen #immunotherapy research in #PancreaticCancer. Read more: hubs.li/Q045S7Gj0

Useful resource paper from @wonjinho1 @hopkinskimmel in @CIR_AACR Cytometric Atlas of Combination Immunotherapy in #PancreaticCancer: Blood-Based Signatures Reveal Vaccine and Checkpoint Inhibitor Responses aacrjournals.org/cancerimmunolr… Datasets available at: sciserver.org/datasets/biome…

WJH Lab is so excited to share the co-publication of two studies in Cancer Immunology Research! @DNSidiropoulos @AmandaHuffPhD @DrLizJaffee Study 1: PDAC Cytometric Atlas of Immunotherapy aacrjournals.org/cancerimmunolr… Study 2: PhII Vax+ICI in PDAC aacrjournals.org/cancerimmunolr…

Now online: Cytometric Atlas of Combination Immunotherapy in Pancreatic Cancer: Blood-Based Signatures Reveal Vaccine and Checkpoint Inhibitor Responses doi.org/10.1158/2326-6…

Investigators from @hopkinskimmel (@wonjinho1, @DNSidiropoulos, @AmandaHuffPhD, @DrLizJaffee) create free atlas of #immunotherapy responses in #pancreaticcancers. hopkinsmedicine.org/news/newsroom/…

Ethan Neumann, a 27-year-old PhD candidate in my lab, devoted himself to studying #fibrolamellar carcinoma, the cancer that claimed his life last week. Please support his father’s effort to establish an endowed research fellowship in Ethan’s name ⬇️ gofundme.com/f/ethan-neuman…

We lost someone extraordinary Ethan Neumann, a PhD candidate in my lab, worked tirelessly to study #fibrolamellar carcinoma, the cancer that would ultimately claim his life On the day before he died he officially became Dr. Neumann: myarchoan.wixsite.com/yarchoanlabs/a…

Neoadjuvant Immunotherapy Promotes the Formation of Mature Tertiary Lymphoid Structures in a Remodeled Pancreatic Tumor Microenvironment doi.org/10.1158/2326-6…

📢It’s now out in ⁦@NatureGenet⁩! 🎉Congratulations to our amazing team ⁦@Yibo_Dai⁩ ⁦@GreenLymphoLab⁩ and wonderful collaborators ⁦⁦@MDAndersonNews⁩ #SpatialOmics #TME #inflammatory niches 🌟Data & Code are publicly available nature.com/articles/s4158…

Mapping the quiet development of a “silent killer.” @NeehaZaidi @wonjinho1 @DrLizJaffee & team @hopkinskimmel present in-depth spatial characterization of early precancer lesions in pancreatic cancer (PDAC), noting the organization of lymphoid cell aggregates into tertiary lymphoid structures. Full report: insight.jci.org/articles/view/…

PIVOT is a very useful open source tool from @AshleyKiemen @andreforjaz @deniswirtz and colleagues at @hopkinskimmel that allows for co-registration and integration of multi-omic spatial data (eg, Visium, cyclicIF, imaging mass cytometry). Preprint: biorxiv.org/content/10.110…