ABDULMUHSIN ALMULHIM retweetledi
ABDULMUHSIN ALMULHIM
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ABDULMUHSIN ALMULHIM
@DR_MUHSINSALEH
Duple Major (Medical Sciences& Medicine), OB&GYN Senior Registrar @NGHAnews Al Ahsa فيروزي الهوى
Al Ahsa, KSA الأحساء،السعودية Katılım Mayıs 2013
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ABDULMUHSIN ALMULHIM retweetledi

🇸🇦🇺🇸 البيت الأبيض @WhiteHouse يودّع ولي العهد السعودي الأمير #محمد_بن_سلمان إثر زيارة دولة رفيعة مدتها يومين للولايات المتحدة، بشريط مصور لمشاهد تاريخيّة من مراسم وفعاليات الزيارة، وبصوت الرئيس #ترامب.
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من غرفة القسطرة في فانكوفر 🇨🇦 إلى قاعة مؤتمر TCT 2025 في أمريكا 🇺🇸
شاركنا في بث مباشر لحالة إصلاح الصمام المايترالي بالمشبك عن طريق القسطرة دون جراحة (PASCAL M-TEER for FMR with ICE guidance)
فخور بكوني طبيب الزمالة المشارك ضمن الفريق ومع الاستشاريين هنا في فانكوفر ❤️
From the cath lab in Vancouver to TCT 2025 in San Francisco
Proud to be the interventional and structural fellow participating with my mentors and our amazing team here in Vancouver
Thanks Scott and Rob.
#TCT2025 #Cardiology #MTEER #PASCAL #StructuralHeart
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ABDULMUHSIN ALMULHIM retweetledi
ABDULMUHSIN ALMULHIM retweetledi

🌴 أطياف النخيل
في كل بيتٍ هنا الأحساء مرضعة
فاضتْ حناناً على الأرياف والمُدْنِ
تاريخُها طاف بالدنيا، وأنزلَها
على المجرات ترعى قمَّة الكونِ
أحســاءُ يا كعبةَ الأطيــاف منزلــةً
وقِبلـــة الحـبّ للشّــيعيِّ والسّـني
يحيا بها الناسُ إخوانًا سواسيةً
مُحصَّنِينَ بوَجهِ الظُلم والغُبنِ
#السعودية_العظمى
#الاحساء
#اليوم_الوطني_عزنا_بطبعنا 🇸🇦
#جمعة_طيبة ✨
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🚨 MRD explained in 30 sec 👇
Cancer isn’t gone just because scans look clean.
Think of it like a garden: 🌱
•Tumor = weeds you pull out
•MRD = tiny roots left underground
🔍 Detection
• Flow cytometry = cell “shapes”
• PCR/NGS (ctDNA) = molecular magnifying glass
🎯 Clinical edge
• MRD (+) → higher relapse risk → intensify tx
• MRD (–) → maybe spare overtreatment
💡 MRD = smoke after a fire. If you still smell it, relapse can reignite.
#OncoTwitter #Leukemia #ctDNA #medtwitter #medx #mrd
@OncoAlert @asco @esmo_open @myesmo @danafarber @mdandersonnews @DGlaucomflecken

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ABDULMUHSIN ALMULHIM retweetledi
ABDULMUHSIN ALMULHIM retweetledi
ABDULMUHSIN ALMULHIM retweetledi
ABDULMUHSIN ALMULHIM retweetledi
ABDULMUHSIN ALMULHIM retweetledi

🚨 HRD score isn’t enough—can genomics unlock smarter PARPi use in ovarian cancer? 🧬
🧾 Study (IJGC, n=221, Chinese OC cohort)
🔍 Genomic profiling + HRD cutoff ≥39
📊 Key biomarkers → longer PFS
✨ BRCA mutations
✨ High indel burden
✨ High LOH
✨ Clonal mutations
🧪 New 4-factor LASSO model
🔹 Indel burden
🔹 BRCA mutation
🔹 MUC12 mutation
🔹 PER1 CNV
📈 Performance
✅ Outperformed HRD/BRCA metrics
✅ Higher AUC
✅ Clearer PFS stratification
💡 Takeaway
PARPi therapy may need genomic risk models, not HRD score alone.
Requires validation in larger, diverse cohorts.
📖 Shu T, Yang F, Gao L, et al. Int J Gynecol Cancer. 2025
🔗 …l-journal-of-gynecological-cancer.com/article/S1048-…
#OncoTwitter #MedTwitter #OvarianCancer #PARPi
@OncoAlert @myesmo @asco @IJGConline @esgo_society

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ABDULMUHSIN ALMULHIM retweetledi
ABDULMUHSIN ALMULHIM retweetledi

🚒 HRR vs HRD - Fire Brigade for Oncologists
👨🚒 HRR = the fire brigade
•Homologous Recombination Repair pathway
•Crew members = BRCA1, BRCA2, PALB2, RAD51, ATM, CHEK2
•Job: put out the DNA “fires” (double-strand breaks) with precision
🔥 HRD = the city when the brigade fails
•Brigade missing key firefighters (biallelic HRR mutations)
•Firetruck blocked (BRCA1 promoter methylation)
•Equipment broken (other defects)
👉 Outcome: Fires spread → genomic chaos (scars, LOH, instability)
This chaos ironically makes tumors extra vulnerable to PARP inhibitors & platinum 💥
⚕️ Clinical pearl:
•HRR = the pathway (who’s supposed to fight fires)
•HRD = the phenotype (city actually burning because the squad isn’t functional)
•Not every HRR mutation causes HRD → need biallelic inactivation or scar signatures.
🔖 Save this: next time you interpret an NGS report or trial readout, you’ll know exactly whether the “fire brigade” is working or not.
#OncoTwitter #MedTwitter #CancerResearch
@OncoAlert @myesmo @asco @esmo_open

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ABDULMUHSIN ALMULHIM retweetledi

🧬 MSI vs MMR — “The Proofreader & Typos” Analogy
📖 DNA = a massive book
📂 Each chapter = a gene
✍️ Each sentence = the genetic code
🔎 MMR (Mismatch Repair) = the Proofreader
🧬 Genes: MLH1, MSH2, MSH6, PMS2
✅ pMMR (proficient MMR):
Proofreader works → catches spelling mistakes (replication errors)
❌ dMMR (deficient MMR):
Proofreader absent → errors accumulate
✒️ Where do most errors (typos) occur?
👉 In repetitive phrases = microsatellites (short, repeated DNA sequences)
📊 MSI (Micro satellite Instability) = The Typos You Can See
🔺 MSI-H (High)
📈 Pages filled with mistakes
🧩 Typos create new “words” = neoantigens
🛡️ Immune system can recognize them as foreign
💉 Predicts strong response to immune checkpoint inhibitors (ICIs)
🔹 MSI-L (Low)
A few scattered typos
Biologically ≈ MSS
🚫 No clinical/therapeutic relevance
🟢 MSS (Stable)
Microsatellite repeats intact
Proofreader did its job → normal mutation burden
❌ Usually resistant to ICIs
💡 Take-home:
•MMR = the proofreader
•MSI = the visible typos
•dMMR/MSI-H = high mutation load + immunotherapy sensitive
@OncoAlert @OncBrothers @ASCO @myESMO @ESMO_Open
#Immunology #MedTwitter #medx #OncoTwitter #immunotherapy

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ABDULMUHSIN ALMULHIM retweetledi
ABDULMUHSIN ALMULHIM retweetledi
ABDULMUHSIN ALMULHIM retweetledi

أتقدم بخالص الشكر والتقدير لمعالي وزير التعليم @minister_moe_sa ولسعادة رئيس @JoufUniversity على ثقتهم الغالية بتعييني عميداً لكلية الطب بجامعة الجوف والله أسأل التوفيق والإعانة
جامعة الجوف@JoufUniversity
#تهنئة | تتقدم #جامعة_الجوف بالتهنئة والمباركة للدكتور عبدالمحسن بن خالد الملحم، بمناسبة صدور قرار تعيينه عميدًا لكلية الطب. تمنياتنا له بالتوفيق والسداد.
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ABDULMUHSIN ALMULHIM retweetledi

@MathewLeonardi Thanks so much for your time & efforts looking forward to meet you soon in an educational events 💐.
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#GRWM / Get Reporting with Me IS BACK! & with Prof Tina Tellum! Unusual Uterus Mass - Benign? Cancer?
A #uterinemass - not clearly a #fibroid, not clearly #adenomyosis. What is it? Watch to hear what we think and how we ultimately describe the mass!
youtu.be/QrhzAmH4MjA

YouTube
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