David Žihala

#Myeloma Paper of the Day: Circulating tumor cells (dependent on 1⁰ genomic events, high-risk 2⁰ events (amp 1q, del 1p, del 13q, biallelic TP53 mutations, increased APOBEC)) are compound biomarker for BM high-risk genomic alterations/tumor load: pubmed.ncbi.nlm.nih.gov/41411148/. #mmsm

#Myeloma Paper of the Day: Selective depletion of B-cell subsets (mature, immature and small pre-B cells + normal PCs) underlies increased risk of infection in myeloma patients treated with anti-BCMA versus anti-GPRC5D bispecific T-cell engagers: pubmed.ncbi.nlm.nih.gov/41405507/. #mmsm

#ASH2025 first of three abstracts from the European CTC consortium #mmsm @Dagostino_MD shows how CTCs are complementary to the R2-ISS and IMS/IMWG genomic risk score, supporting the future integration of CTCs in myeloma staging! @LucaBertamini @TomasJelinekMD @DZihala

#Myeloma Paper of the Day: Study of extramedullary myeloma tumor microenvironment finds significantly reduced effector-to-tumor ratio, fewer CD4⁺ T cells, more regulatory CD16⁻ NK cells, higher proportion of exhausted, tumor-reactive CD8+ T cells: pubmed.ncbi.nlm.nih.gov/41236394/. #mmsm

📢We are thrilled to invite you to XX. Myeloma & VIII. Cell Therapy Workshop, organized by Blood Cancer Research Group and Czech Myeloma group 📢 Join us in Ostrava 🇨🇿 for 2-day multidisciplinary workshop 🧬 Save the date and follow us for more updates!

#Myeloma Paper of the Day: Spatial transcriptomics reveals profound subclonal heterogeneity and T-cell dysfunction (exhausted TIM3+/PD-1+ T-cells) in extramedullary myeloma with oxidative phosphorylation representing the major metabolic program: pubmed.ncbi.nlm.nih.gov/39172759/. #mmsm

We talk about diversity & inclusion in academia BUT: -open access journals with 5k$ publication fee -congresses with >50$ submission fee and registration fee of 100s of $ -meet the expert sessions you have to pay for ... Change only happens when we act instead of pretend!

📢Happy to share our new paper recently published in @LeukemiaJnl. @TomasJelinekMD and his team conducted a comprehensive NGS analysis to reveal molecular changes from the time of diagnosis to extramedullary #MultipleMyeloma relapse. Congrats to authors🙌🔗rdcu.be/dBRSu

PhyloFisher is out now in @PLOSBiology. A tool/methods/resource for phylogenomics of eukaryotes. journals.plos.org/plosbiology/ar…. @kolecko007 @eme_laura @andrewjroger @RokasLab @shenxingxing1 @EricSalomaki et al (not on Twitter)

I am super happy to announce our new publication! @Ostravska_Uni @BCRG_Ostrava nature.com/articles/s4137…

#preprint wondering why your assembly is so strange? try Karyon for diagnosing possible causes: "Karyon: a computational framework for the diagnosis of hybrids, aneuploids, and other non-standard architectures in genome assemblies." biorxiv.org/content/10.110…

Still a few weeks left to apply for the open PhD position in my lab to study #protists diversity & interactions! Read more about the position: euraxess.ec.europa.eu/jobs/642222 @UniWarszawski @BiolUW #NCN #MicroDiver

(2/2) I am also hiring 3-4 more PhD students soon, starting Fall 2021 - Fall 2022. If you know anyone interested in working in genomics, microbial ecology, and protists, please send them my way. Official job ads will be out soon. @protistologists @ISEPprotists

(1/2) My latest NSF proposal "PurSUiT: Sampling amoeboid protists as a reservoir of unknown/undescribed eukaryotic diversity" has officially been awarded. In the next few months, I will be recruiting 2 postdocs (microbial ecology and genomics). #NSFfunded @protistologists

It's a good day today!

Still a few weeks left to apply for this open PhD position to study #anaerobic microbial #eukaryotes (#protists) and their prokaryotic comrades. Read more about the position: tinyurl.com/syntrophy Or student life at @lunduniversity: lunduniversity.lu.se/student-life

The March issue of Blood Cancer Discovery is now online! bit.ly/38etDYf

We are looking for a bioinformatician with knowledge of microbial 'omics to support ongoing research and education at @MIB_WUR. Come join us! Apply here: wur.nl/en/vacancy/Bio… pls RT!

1/ How do microbial eukaryotes and prokaryotes work together to survive in anoxic environments? Come join my lab at @Biology_LU as a PhD student to investigate the #evolution and #molecular basis of metabolic syntrophy in anaerobic #protists. #phdpositions tinyurl.com/syntrophy

Identification of resistance pathways and therapeutic targets in relapsed multiple myeloma patients through single-cell sequencing. Great congrats Yael, Ido and team! @NatureMedicine⁩ #mmsm ⁦@IMFmyeloma⁩ ⁦@theMMRF⁩ ⁦@myelomacrowd⁩ nature.com/articles/s4159…