Viola Fanfani
417 posts

Viola Fanfani retweetledi

Single-sample network inference remains an area of ongoing development. A new method, BONOBO, uses empirical Bayes to estimate single-sample correlation matrices drawing evidence from a population of samples.
@DrEnakshiSaha
@violafanfani
@HarvardBiostats
genome.cshlp.org/content/early/…
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Viola Fanfani retweetledi

Live-post of Maggie Beheler-Amass: Dynamic gene regulatory network inference with interpretable, biophysically-motivated neural ODEs #ISMB2024 bsky.app/profile/michae…
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Viola Fanfani retweetledi

Huge milestone for @SynGenome with 10 new papers on 9 new chromosomes and a #yeast cell with > half #synthetic #genome! Proud to have contributed to 8 of them with @violafanfani and @biomed_ai_geno in my lab, who analysed tons of data! @SBSatEd @EdEngBio @BioMedAI_CDT
Sc2.0@SynGenome
It's Sc2.0 day! 10 new papers to check out in Cell, Molecular Cell, and Cell Genomics! @ProfTomEllis @JefBoeke @ChantalSHEN @caiyizhi @BABlount @MatthewWChang plus all everyone involved!
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Viola Fanfani retweetledi

My dear colleague and friend, Claudia Cea @claudiacea8, has just left Columbia to advance her research career as a post-doc at MIT. I was lucky to to work with her over years, and I'm gladly announce that our paper came out today in Nature Materials: nature.com/articles/s4156…
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Elucidating tumor heterogeneity from spatially resolved transcriptomics data by multi-view graph collaborative learning | Nature Communications
nature.com/articles/s4146…
#Bioinformatics




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CellRegMap is finally out in @MolSystBiol! 🎉 Introducing a statistical framework to map context-specific eQTL using single-cell data, without the need to discretise single cells into distinct groups. Dream work with @tobi_heinen, @OliverStegle et al! Tweetorial 👇 (1/n)
Mol Syst Biol@MolSystBiol
CellRegMap: a statistical framework for identifying and characterising genetic effects on gene expression in single cells --> bit.ly/3As8loN @OliverStegle @StatGenomics @AnnaSECuomo @DKFZ #eQTL #geneticinteraction #singlecell
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Why are bioinformatics pipelines different than workflows in data engineering? My thoughts on the ecosystem of workflow managers, and where the field might be headed: bsiranosian.com/bioinformatics…
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Excited to share scMoMaT, a mosaic integration method for single cell multi-omics data. scMoMaT jointly learns bio-markers (marker genes, TF motifs and proteins) to interpret each cell cluster in addition to the integrated cell embedding. biorxiv.org/content/10.110…

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Excited to share our @Cancer_Cell article presenting a pan-cancer integrative histology-genomic analysis, multimodal integration improves prognostic models, discovers molecular & morphologic correlates of prognosis. bit.ly/3PbnUVM
@harvardmed @BWHPath @broadinstitute 1/2

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📚 Natural Language Processing from Stanford University: Distilled Notes
👉🏼 nlp.aman.ai
- NLP is one of the most popular #AI domains, widely used from language translation to auto-complete to voice assistants.
- Presenting notes from Stanf…lnkd.in/gBBWfvUi
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Harvard CS109A #DataScience course materials — huge collection free & open!
1. Lecture notes
2. R code, #Python notebooks
3. Lab material
4. Advanced sections
Find it all here:
harvard-iacs.github.io/2019-CS109A/pa…
—
#BigData #DataScientists #MachineLearning #AI #DeepLearning #NeuralNetworks

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The best linear algebra course out there. PERIOD.
For Free!
MIT's Professor Gilbert Strang.
Go through these videos, and you'll never ever have a problem with linear algebra again!
ocw.mit.edu/courses/18-06-…

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Wow! Huge valuable database for cancer research! sciencedirect.com/science/articl…
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Two of the best statistics books using biological data as examples: 1. Modern Statistics for Modern Biology lnkd.in/e9jSU6xq
2. Data Analysis for the Life Sciences Series lnkd.in/ejWp5egX
I am grateful to have those open materials available online. #genomics #rstats
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PyGenePlexus: A Python package for gene discovery using network-based machine learning biorxiv.org/content/10.110…

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New preprint on Graph Transformers! We show that a vanilla Transformer on nodes and edges becomes a powerful graph learner (in both theory and practice) if simple auxiliary input embeddings are provided. We call this Tokenized Graph Transformer (TokenGT).
arxiv.org/abs/2207.02505

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So excited to share our paper "Genome-wide mapping of somatic mutation rates uncovers drivers of cancer" is out on @NatureBiotech (and open access)! nature.com/articles/s4158…. Here's a🧵on what we did and what we found!
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Pan-cancer whole genome comparison of primary and metastatic solid tumors
biorxiv.org/content/10.110…
“5 cancer types - breast, prostate, thyroid, kidney clear carcinoma & pancreatic neuroendocrine - display an extensive transformation of their genomic landscape in advanced stages”.


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