Daisy Spark

Very excited to see this review finally out – a look into the past, present, and future of schizophrenia drug discovery with a focus on improving preclinical to clinical translation. Thanks to ⁦@gdstewart82⁩ ⁦@chrislangmead⁩ ⁦@AFornito⁩ nature.com/articles/s4139…

Thanks to Michela Vermeulen, @roailim, @CJHatzipantelis, Patricia Rueda, Tara Sepehrizadeh, Michael De Veer, Clotilde Mannoury la Cour, @AFornito, @monica_langiu, @gdstewart82, @jess_nithi and @chrislangmead

New paper from a collaborative effort in delineating the role of GPR88 in motivational behaviour (and the surprising absence of striatal dopamine dysfunction) sciencedirect.com/science/articl…

Are there glutamate subtypes in schizophrenia? (eg treatment resistant vs responders). If so, we'd expect to see increased glutamate variability in patients compared to healthy volunteers. This is what we looked at in this meta-analysis (1/) #Fig1" target="_blank" rel="nofollow noopener">nature.com/articles/s4138…

Important study for neurosci field. Shows that the push to study males and female rodents (of a single strain) is misguided, and arguably leads entire fields to draw erroneous conclusions about sex differences. Sex differences in C57Bl/6 mice do not generalize to other strains.

Rebranding as Dr Spark

" to accelerate development of targeted therapeutics ... regulatory agencies and the pharmaceutical industry must embrace ...trials focused on pathophysiologic pathways that impact specific symptom domains in subsets of patients, agnostic to diagnosis.' nature.com/articles/s4138…

Final version of @kristinasabr 's fab review on the role of cortico-striatal circuitry in psychosis, w/ J Tiego, now out in @BiologicalPsyc1: biologicalpsychiatryjournal.com/retrieve/pii/S…

A game changer for neuroscience: MRI with millisecond precision. Out now in @ScienceMagazine science.org/doi/10.1126/sc…

📢📢NEW PAPER from the lab! Combining #optogenetics and #fMRI is opening up new avenues for research into polysynaptic functional networks. Here we openly share our most detailed protocols and step-by-step instructions for doing opto-fMRI in rodents! sciencedirect.com/science/articl…

Online today @BiologicalPsyc1 a perspective I co-authored with @Valerio_Zerbi 👏on the use of rodents to model & study brain dysconnectivity ➡️tinyurl.com/2dyvbhyn This is part of upcoming special issue on biological mechanisms of human brain dysconnectivity (more soon!)

WOW!! 'Our data show that exposure to male versus female experimenters’ scents induces differential behavioral responses and alters responses to antidepressant-relevant doses of KET in mice.' nature.com/articles/s4159…

I'm pleased to share our Perspective on 'Functional Neuroimaging in Psychiatry', out today in @NeuroCellPress, with @YunzheNeuro and Ray Dolan, @MPC_CompPsych. We reflect on progress and impasses over 3 decades' research. sciencedirect.com/science/articl… cell.com/neuron/fulltex…

Female mice are less variable than male mice once again! bsd.biomedcentral.com/articles/10.11…

New open access paper out in @molpsychiatry using PET-MR to investigate relationships between glutamate, dopamine, & cortical gray matter. With Antoine Rogeau, @sameerjauhar and @Matt_Nour. nature.com/articles/s4138… 🧵1/n

@KynaConn @gdstewart82 @chrislangmead @AFornito Thank you!!!

@DaisyLSpark @gdstewart82 @chrislangmead @AFornito Congrats!! 🥳 🎉

Very excited to see this review finally out – a look into the past, present, and future of schizophrenia drug discovery with a focus on improving preclinical to clinical translation. Thanks to ⁦@gdstewart82⁩ ⁦@chrislangmead⁩ ⁦@AFornito⁩ nature.com/articles/s4139…

Proud to have spent my undergrad and postgrad at @MonashPharm (also hi mum & dad I'm famous) | Monash ranks number one in Pharmacy and Pharmacology - 2022 QS World Uni... youtu.be/kc6FCVh0Lt4 via @YouTube

@NilushiKarunar2 @gdstewart82 @chrislangmead @AFornito Thanks Nel! Of course – very fitting for their latest assignment

@DaisyLSpark @gdstewart82 @chrislangmead @AFornito Congratulations Daisy 👏🏼👏🏼 are you happy for me to showcase this to the 3011's? It's brilliant 😊

@sim_scientist @gdstewart82 @chrislangmead @AFornito Thanks Sim!