Daniel Jacobson

In 1999, Tom Maniatis discovered something remarkable: neurons achieve self-avoidance via stochastic methylation of the protocadherin gene cluster. We've just discovered this locus is an evolvable in-vivo barcode across the human tissues: biorxiv.org/cgi/content/sh… 🧵

How do tissues organise, adapt, or collapse? 🧬 We’re looking for a postdoc with strong quantitative skills to tackle these questions in a highly interdisciplinary project bridging spatial omics, ecology & mathematical modelling. Apply 👉 tinyurl.com/3d37d3st Please share.

We are rebuilding 💪 nature.com/articles/d4158…

Just published in @TheLancet! We show that the capsule sponge improves Barrett's surveillance, helping prioritize high-risk patients for endoscopy & offering a more efficient, patient-friendly approach for low-risk individuals. thelancet.com/journals/lance… #GITwitter #Earlydetection

[Preprint alert] We’re thrilled to introduce EnrichMap: a powerful method for spatial gene set enrichment. It’s spatially aware, biologically meaningful and built for the next generation of spatial transcriptomics. biorxiv.org/content/10.110…

Are you interested in cancer genomics and cancer evolution? A 3-year postdoc position available to join my MRC-funded project on #ChromosomalInstability #CancerPhylogenetics! Please get in contact if you are interested. Deadline 30 Apr 2025. jobs.surrey.ac.uk/017125

Happy to see this invited world view article published; My personal call for clinicians & researchers working in oncology to be more empathetic when it comes to presenting patient data which has life-changing implications for the individuals in question @NatRevGastroHep

Excited to share our new preprint exploring the potential to personalise treatment for non-small cell lung cancer (NSCLC) using in silico modelling: biorxiv.org/content/10.110…

🎉 Excited to share that our paper, "Context-dependent effects of CDKN2A and other 9p21 gene losses during the evolution of esophageal cancer," has been published in Nature Cancer! 🧬 Read more: nature.com/articles/s4301…

Delighted to introduce our new spatial transcriptomics tool, SpottedPy, recently published @GenomeBiology, allowing the identification of tumour hotspots at different scales and the exploration of distances and overlap with tumour microenvironment niches: genomebiology.biomedcentral.com/articles/10.11…

🎓PhD Opportunities in Early Cancer Detection! Join us for a fully funded 3.5-year PhD starting Oct 2025 🌟Projects include modelling progression risks in Barrett's Oesophagus 🗓 Apply by 16 Feb 2025 #phdpositions #AcademicTwitter #CancerResearch

🚨So proud to present the first study from our @CCG_UCL group together with @CharlesSwanton @NnennayaKanu and led by @ojlucas with key collaboration @Ward__Sophie and fundamental support @Rija_Zaidi_ @abi_bunkum & many others Out in @NatureGenet 👇 doi.org/10.1038/s41588… 🧵👇

How does immune failure enable metastasis and evolution in breast cancer? Join us for a computational #singlecell #PhD @ICR_London. Learn more and apply: icr.ac.uk/studying-and-t… #CancerResearch #Bioinformatics #AcademicTwitter

📢 Exciting PhD Opportunity! Join evilab.ai to explore immune cell populations in healthy and premalignant breast tissues. Study how BRCA mutations shape the immune landscape and the impact of PARP inhibitors on mutational signatures. Apply>bit.ly/3Y5CN2F

🚨 Interested in spending 4 years studying how tumours evolve and developing new diagnostic methods? Take a look at the Alliance for Cancer Early Detection (ACED) PhD studentships available in my lab @EarlyCancerCam @CRUKCamCentre: earlycancer.cam.ac.uk/aced-phd-stude… Deadline 4th Nov!

Finally out in @NatureProtocols : our group's workflows for end to end computational pathology. Compatible with UNI and other foundation models. Led by @ElNahhasOSM from @katherlab journal link: nature.com/articles/s4159… full text: rdcu.be/dT35l

The winner of the 2024 Mercury Prize is... @Englishteac_her - 'This Could Be Texas' 🏆⚡️ #MercuryPrize

How do healthy tissues evolve to become cancerous? Delighted to share our latest research tracking the somatic evolution that occurs in the decades before AML. 👇Implications for early detection and early interception. biorxiv.org/cgi/content/sh…

Routine whole genome sequencing can improve treatment options for children with cancer, according to a recent NHS trial. Dr @DanH_Jacobson writes more about this study in BioNews: progress.org.uk/routine-whole-… #cancer #childhoodcancer #genetics #genomics #DNA #wholegenomesequencing

UK Science Comedy Festival is THIS SUNDAY at Camden's People Theatre! Come to see a whole evening-and-afternoon of silliness, science, nonsense, chaos and very funny people. Plus me, talking about how much I actually love brains!🧠🧠🧠 Tickets here: cptheatre.co.uk/whatson/The-UK…