Daniel Rayner

Combining inhaled corticosteroids (ICS) with short-acting beta-agonists (SABA) and combining ICS with formoterol were each associated with lower risks of severe asthma exacerbations, compared to SABA alone. #ACAAI24 ja.ma/3Ysodm2

A guideline panel considered evidence on the benefits and harms of SGLT-2 inhibitor therapy for adults with chronic kidney disease over a five year period and provided new recommendations. Read them ⬇️ bmj.com/content/387/bm…

Just published systematic review found moderate certainty evidence that monitoring oncology patients’ status by asking them to complete patient-reported outcome measurement instruments reduces mortality and improves quality of life. Remarkable! pubmed.ncbi.nlm.nih.gov/39136947/

Recently published shocker regarding prediction of patient outcomes. Clinical intuition often as good, sometimes better than formal prediction models. jclinepi.com/article/S0895-…

Recent post about shocker showing clinical intuition often as good, sometimes better than formal prediction models generated interest. Here demonstrating the relation between the two in discrimination. Axes are c-statistic.sciencedirect.com/science/articl…

Struggling to interpret the discrimination of #prognostic models? 🤔 Our new #GRADE paper demystifies whether an AUC of 0.7 is just right, or not enough. Discover how to assess model accuracy with confidence! 📊🔍 sciencedirect.com/science/articl… @GuyattGH @AlfonsoIorio @Richard_D_Riley

Just published review very surprising finding: clinical intuition & formal empirically derived prediction models show similar discrimination in most cases. Reinforces that prediction models should demonstrate benefits to patients before widespread adoption doi.org/10.1016/j.jcli…

Got #eczema #atopicdermatitis? These new systematic reviews of randomized trials compare all major #treatment options: 👇👇 jacionline.org/article/S0091-… - Topical treatments network meta-analysis jacionline.org/article/S0091-… - Systemic treatments and phototherapy network meta-analysis

Examine the global variations in #HeartFailure readmissions and mortality with #JACC: bit.ly/3KeeNnN #CardioTwitter @DouglasLeeMD

Grateful to be presenting two posters about COVID-19 vaccine efficacy in the transplant population at #ATC2023SanDiego

JUST PUBLISHED - #Obesity as an independent risk factor for #COVID19 severity & mortality 🔎 📚 171 eligible studies, w 149 studies (12,045,976 participants) providing quantitative data for at least one of our meta‐analyses. buff.ly/3WDqbP6