Danny Holoch

Pleased to announce the publication in @NatureGenet of our work with Michel Wassef, Raphaël Margueron and others! nature.com/articles/s4158… (1/2)

🚨 Job Alert! Please RT 🙏 @ERC_Research-funded postdoc position in our team (up to 3 years) to explore dosage compensation during mouse development 🧬🐭 Join a dynamic, collaborative community @CbiToulouse! 👉 See how to apply here: shorturl.at/De0kj

Happy to share two post-doc papers co-authored with the amazing @AnaMonteagudo4 and @teresa_urli. We had amazing collaborators for both projects, even our supervisor @maxvcg joined in on the experimenting! 1: pubmed.ncbi.nlm.nih.gov/39180406/ 2: rdcu.be/dXXqh

Usually, I just trash these spam conference invites. But it's not every day I get an email from one of my scientific heroes.

What does the RNA binding surface of PRC2 actually do? We show that part of the RNA binding surface is required for PRC2 function through interactions with nucleosomes, but we find no evidence that RNA is in play. nature.com/articles/s4158…

Very glad to share our latest publication on TET mode of action ! #drosophila #epigenetics science.org/doi/10.1126/sc…

Congratulations Danesh Moazed of @harvardmed, newly inducted #NASmember! #NAS161 #genetics #cellbiology

We are immensely grateful for this collaboration with @AVincentSalomon and for funding support from @institut_curie, @Inserm, @CNRS, @FondationARC, @FRM_officiel, @Fondationfrance, @AgenceRecherche and @canceropole. (3/3)

We combine a powerful isogenic cell culture model with a first-of-its-kind ChIP-seq analysis of follicular lymphoma samples from a unique longitudinal patient cohort to understand the mechanistic impact of EZH2 gain-of-function mutants on chromatin and transcription. (2/3)

Glad to announce the publication in @NatureComms of our study rdcu.be/dFBcE by Pierre Romero & Laia Richart in Raphaël Margueron’s lab at @institut_curie on the molecular consequences of EZH2 mutations found in non-Hodgkin lymphoma. (1/3)

@toma_bln Congratulations Thomas!

So honored of this! Amazing discussions at #ICTE2024 during the poster sessions! Already looking forward to the next edition !

Happy to share our review dx.doi.org/10.1002/wrna.1… we highlight the similarities and differences between ciliates and other eukaryotes in small-RNA-directed chromatin silencing. @IJMonod @CNRSbiologie @toma_bln @DannyHoloch

@maxvcg Looks like really beautiful work. Looking forward to reading this!

🚨New Preprint🚨 In this study, we set out to determine how the de novo DNA methylation program impacts the 3D cis regulatory landscape. Comments welcome! Here's a thread detailing our study's key findings (1/12) biorxiv.org/content/10.110…

@AdrianoAguzzi @baheesters 🤣 en.m.wikipedia.org/wiki/Donaudamp….

@AdrianoAguzzi @baheesters Indeed. The second alternative is clearer. The first three words together function as a single adjective to describe what kind of receptor we are talking about.

Preprint alert. We’re thrilled to announce the latest work from our lab: The nuclear PIWI-interacting protein Gtsf1 controls the selective degradation of small RNAs in Paramecium. A thread with our key findings: (1/6) biorxiv.org/content/10.110…

DNA methylation can antagonize Polycomb-mediated gene silencing - neat! biorxiv.org/content/10.110…

🚨Preprint Alert🚨 I am very proud to present our latest work, describing how DNA methylation shapes the polycomb landscape. A team effort, led by @jrichardalbert, @teresa_urli, and @AnaMonteagudo4 in the lab. Here's a 🧵 highlighting 🗝️ findings (1/12) biorxiv.org/content/10.110…

Very glad to share our preprint: Non-catalytic function of PRC2 in the control of small RNA dynamics during programmed genome elimination in Paramecium biorxiv.org/content/10.110…. Feedback and comments are welcome !

Very honored to be part of the @EMBO community. Thanks to past and present lab members, and collaborators, and to @IJMonod for a great environment.