David B Sauer

Step-by-step protocol to make stable cell lines for large-scale expression of muscle-type nAChR (and other multi-subunit targets)! By the inexhaustible and tenacious @Anna_Liiiiiiii in collab of @CMS_CDG_Oxford in @MRC_WIMM and @CmdOxford cell.com/star-protocols…

Our study of the CAT1 amino acid transporter and viral receptor is now online in @NatureComms! Led by the incredibly talented @mingda_ye, with colleagues from @CmdOxford, @OxfordStrubi, @CAMS_COI_Ox, @NDMOxford, and supported by @im2pact_project nature.com/articles/s4146…

New work out today in PNAS! Secondary active transporters are everywhere, but direct observation of their structural dynamics is rarely achieved. Here, we capture the real-time dynamics of a sodium-coupled dicarboxylate transporter using smFRET. 🧵⬇️ doi.org/10.1073/pnas.2…

Thrilled to submit another paper with Yin Yao Dong @CMS_CDG_Oxford and @DavidBSauer 🥳🥳🥳 ✍🏻✍🏻✍🏻🦠🦠🦠 (📸photo credit: Claudia Burn-Leefe)

Gluebodies for improved crystal reliability and alternative crystal forms! (also inspiring Di-Gembody for cryoEM) @CmdOxford @FrankvonDelft Now out in ACS Central Science @ACSCentSci Many thank to great supporters! @RosFrankInst @OxfordStrubi @DavidBSauer doi.org/10.1021/acscen…

Closing soon! Please apply if you are interested in targeting membrane proteins with new therapeutics!

Join our group in the Centre for Medicines Discovery at Oxford Univ. @CmdOxford @UniofOxford !!!! Happy to chat about any questions about the role and science. Oxford will assist with a skilled worker visa. Please RT! my.corehr.com/pls/uoxrecruit…

I'm far more active on the Bluesky platform, if you want to find me there bsky.app/profile/davidb…

Ugh. In case it wasn't obvious, this account was recently hacked. (Hopefully) now resolved

First keynote of the day from ⁦@DavidBSauer⁩ #bcium2025 …before coffee and chocolates from ⁦@DECTRIS_News⁩ ⁦@ccp_em⁩ ⁦@ccp4_mx⁩ ⁦@instructhub⁩

New plan: already delayed flights have no further hiccups AND fast passport control. Trying to be hopeful 😬 Gratitude to @VirginAtlantic customer serv. for coming up with a plan

Should I start taking boats??

Another year, another mess with canceled flights. 🤬 @VirginAtlantic - Flight canceled txt, but we'll automatically rebook you. - (I called after silence) We subcontracted the flight; you must sort out with @Delta

Cheeky visit to @unisabana during a family trip! Spectacular campus in the Colombian Andes Thank you @NuryOlaya2 for a great discussion and showing us around!!

I should add one great sadness of last year, losing our colleague @sagaraturi An energetic and passionate scientist gone too soon

Two highlights of 2024 contained in one photo 😀 Titled "First CNS submission of a newborn (aged 4 days)" Alternative title "Type VERY quietly!"

Just finished our "State of the Group" talk in lab meeting 2024 Recap - 9 papers published - 6 papers in review - 2 DPhils What's next - More papers in flight, landing soon - Expand our toolbox and biomed relevance Another year of great pride in our team!

And a parallel study on human muscle-type AChR by @RyanHibbs10 and colleagues!! Wonderful to see that we agree on many points, while also making distinct and novel discoveries on AChRs in myasthenia gravis biorxiv.org/content/10.110…

Now online! @Anna_Liiiiiiii fantastic work on the structure of the Human adult Muscle-type nicotinic receptor. Wonderful collab with @CMS_CDG_Oxford at the @MRC_WIMM and @CmdOxford biorxiv.org/content/10.110…