David Darley

Excited to announce our second patient was successfully transplanted with our genetically engineered porcine kidney. A historic milestone for #organ #transplantation. Thank you @mgh_transplant for being an incredible partner. Read the press release: shorturl.at/B6SIK

Antibodies against donor HLA and non-HLA antigens are produced locally in #CLAD lungs containing lymphoid aggregates with activated B cells and immunoglobulin-secreting plasma cells. 🫁 @Tereza_Martinu 🔗: jhltonline.org/article/S1053-…

Advances in #LungTx: repeated doses of amniotic fluid-mesenchymal stem cells can improve severely damaged donor lungs and post-op outcomes. Injections improved graft inflammation, function, and reduced primary graft dysfunction. @lindstedt_s 🔗: jhltonline.org/article/S1053-…

Personal exposure to black carbon air pollution in the first 3 months lowers maximum FEV1 achieved post lung transplant and increases the risk of chronic lung allograft dysfunction. 🫁 @Frungus_lungrus 🔗: jhltonline.org/article/S1053-…

ERJ: Fungal lung disease occurs independently or complicates underlying lung disease. Type and severity are determined by host immunity, geography and environment. Next-generation sequencing is revolutionising diagnostic and treatment strategies. bit.ly/3TFwAJ3

Lung Transplant programs should not be forced to accept bundled services of third party lung procurement organizations. #LungTx 🫁 @VanderbiltU 🔗: jhltonline.org/article/S1053-…

I can't figure out if vaccines work or not. Tough one. I can see why RFK Jr is so concerned. Need Sherlock Holmes on this one.

We're proud to honor the #TTS2024 winners of the prestigious 2024 Medawar Prize, the highest honor bestowed by the society for outstanding contributions to the field of transplantation. Congratulations to Ronald W. Busuttil, Mehmet Haberal, Shaf Keshavjee. 🏆 👏

"Ischemia Reperfusion Responses in Human Lung Transplants at the Single Cell Resolution" by Wong et al. doi.org/10.1016/j.ajt.…

Check out the @TheJHLT publication from @rashmi_2023, @jrgreenland and collaborators from @pitt_medicine and @UHNTransplant showing small airway brushes predict chronic lung transplant rejection: jhltonline.org/article/S1053-…. @UCSFMedicine

A mindmap for PhD students struggling with their thesis structure

Does using a lung graft with a positive BAL make a difference in outcomes? This manuscript gives us some insights! 🔗: jhltonline.org/article/S1053-…

ISHLT endorses the 16th International Congress on Lung Transplantation that will be held 12-13 September in Paris, France. The event is organized by experts in #LungTx, and preferred registration fees are available through 15 July. 📆 Learn more at 🔗 bit.ly/3XCjjnA

No better in Australia. Only around a half of patients with bronchiectasis in Europe perform regular airway clearance. Techniques and use of airway clearance management is heterogeneous, suggesting the need for clearer guidelines and stronger evidence. bit.ly/3v2CFGy

Excited to share this report describing our novel reporting scheme for transbronchial biopsy eosinophils after Lung Transplant in @TransplantJrnl. Developed at @SVHSydney with sub-study validation by @Tereza_Martinu's team at @UHNTransplant🙏 journals.lww.com/transplantjour…

@RamendraRayoun @Tereza_Martinu @AndrewTSage @SKeshavjee Great work @RamendraRayoun and @Tereza_Martinu! Do you see PGA4 as being commercially available in the future?

Silent microaspiration can cause lung injury without any symptoms of reflux. Here we identified a protein that is found in the lungs of transplant patients with chronic microaspiration and predicts future rejection. @Tereza_Martinu @AndrewTSage @SKeshavjee

Microaspiration is a risk factor for rejection in lung txp recipients. PGA4 is a novel biomarker of aspiration that predicts post #lungtx outcomes. @RamendraRayoun @Tereza_Martinu @UHNTransplant 🔗: jhltonline.org/article/S1053-…

@TheJHLT @BradGardiner6 Congratulations @_SEnnis!

In a contemporary cohort of well vaccinated and widely treated lung transplant recipients, COVID-19 infection resulted in mild disease and had minimal impact on lung function. @BradGardiner6 🔗: jhltonline.org/article/S1053-…

After lung transplant, a first subclinical minimal rejection episode is usually regarded as benign. The immune landscape of the biopsy suggests this is not always true! Congrats to my former grad student @BeberSamuel on this paper: #tbl0005" target="_blank" rel="nofollow noopener">jhltonline.org/article/S1053-… @UHNTransplant

A machine called ECMO can perform the work of the heart and lungs entirely outside the body. “ECMO is transforming medical care,” Clayton Dalton writes. “But it also complicates care when life inevitably begins to end.” nyer.cm/FtiWqbm