Perrais David
137 posts

Perrais David
@DavidPerrais
Full time scientist interested in membrane trafficking and synapses











Karl Popper (1902-1994) on what it means to be a rationalist ✍️ When I speak of reason or rationalism, all I mean is the conviction that we can learn through criticism of our mistakes and errors, especially through criticism by others, and eventually also through self-criticism. A rationalist is simply someone for whom it is more important to learn than to be proved right; someone who is willing to learn from others — not by simply taking over another's opinions, but by gladly allowing others to criticize his ideas and by gladly criticizing the ideas of others. The emphasis here is on the idea of criticism or, to be more precise, critical discussion. The genuine rationalist does not think that he or anyone else is in possession of the truth; nor does he think that mere criticism as such helps us achieve new ideas. But he does think that, in the sphere of ideas, only critical discussion can help us sort the wheat from the chaff. He is well aware that acceptance or rejection of an idea is never a purely rational matter; but he thinks that only critical discussion can give us the maturity to see an idea from more and more sides and to make a correct judgement of it. -- as mentioned in All Life is Problem Solving (1999)



We are seeking an Assistant Professor in molecular and cellular neurobiology! For more info see: uu.nl/en/organisatio…




This video is almost unbelievable. The Francis Scott Key Bridge in Baltimore literally collapsed this morning after it was struck by this large ship.

We developed an excitation module for 3D multi-color MINFLUX that is simple, stable and cost-effective and will allow for ultra-fast MINFLUX with a high accuracy. biorxiv.org/cgi/content/sh…

#ImageOftheMonth O.Thoumine @iins_bordeaux & @JTeillon Spheroid made of dissociated rat hippocampal cells observed using confocal after 14 days in culture. A few neurons expressing td-Tomato (coded in gold) have extended long neurites.The spheroid diameter is around 200 µm.




Nat Biotech recently published a provocative study claiming single synapse RNA-seq. Unfortunately, there is no evidence demonstrating droplet-based sequencing of single synaptosomes. They are likely studying random pieces of cellular debris. Our reply: nature.com/articles/s4158…




