Eric Betzig
1.1K posts

Eric Betzig
@Eric_Betzig
An engineering physicist sometimes masquerading as a biologist or, on one occasion, a chemist. Aspiring astronaut. Nuclear is the way.

Four foundries on Earth cast the single-crystal blades and vanes that let a gas turbine convert 1,500-degree gas into electricity. PCC and Howmet hold about 80% of the single-crystal market. Doncasters and CPP take most of the rest. Every heavy-frame gas turbine ordered in the past 18 months is sold out through 2030. Elon Musk on @dwarkesh_sp traced his own xAI Colossus power problem one layer down past the turbines and landed on the blades. He said SpaceX and Tesla will likely have to cast their own. We manufacture chemicals. Casting a single-crystal blade is not a metallurgy problem. It is a chemistry problem. The four foundries that cast them spent thirty years driving sulfur down to parts per billion and oxygen down to parts per million. Vacuum, gradient solidification, and mold chemistry are why nobody else can cast them. The bottleneck is chemistry.

Walter Isaacson reveals the brutal philosophy Steve Jobs and Elon Musk both share about leadership "Jobs said the same thing that Musk said to me. People like you love wearing velvet gloves. You like to sweet talk things, sugarcoat things. He said, I'm just a working class kid and I don't have that luxury. If something sucks I got to tell people it sucks or I got a team of B players" "There are a lot of successful people who are much kinder. But it's sometimes necessary to be much more brutal and honest"

Early iSOAR 5D movie of membrane and mitochondria dynamics over 3 hrs at 3 min intervals in the head of a zebrafish embryo 6 dpf, covering a 300 x 1000 um FOV at 193 x 193 x 550 nm resolution (0.8 TB total).

Ever wonder why we decide to build a new microscope and how we go about it? For the last lecture this semester of the graduate microscopy class Na, Gokul, and I teach at Cal, I spoke on our developing iSOAR microscope, a swept HILO design with adaptive optics and structured illumination. iSOAR is designed to produce the petabytes of high resolution 5D videos of subcellular dynamics in zebrafish we need to train the multimodal vision models at the heart of our Cell Observatory Initiative. We still have some work to do, but the scopes are coming along nicely. It's an exciting time at the Observatory, so if you're experienced and looking for a job in zebrafish transgenics, ultra-high throughput image processing, or the development of 5D spatiotemporal foundation models for interpreting the insane dynamic complexity of living matter, we'd love to hear from you. (sup@berkeley.edu, betzige@janelia.hhmi.org).

Full duration and full thrust 33-engine static fire with Super Heavy V3

Amsterdam has now banned all public advertisements for meat products, in a bid to change "social norms" and reduce citydwellers' meat consumption by half by 2050. Green politicians like Anneke Veenhoff and Anke Bakker spearheaded the ban.

Here comes Ship 40 as it heads to Masseys for testing


Once again I'm feeling the double edged sword of finding out that @SpaceX is not just decades ahead of us in execution but months or years ahead of us in planning (if this bit of speculative rumor chasing is true...). 18 days ago I told my group we should try to launch from Louisiana. (Yeah, I think SpaceX is going to use this land for a launch site, if they're indeed closing.) You don't need a logistics hub in Louisiana to transport Starships between Texas and Florida. Especially not one that's 136,000 acres. There are only three things I can make sense of SpaceX using that much land for: launch site, natural gas production, and solar power for air separators and condensers. Preferably all three. And Louisiana is just about perfect for SSO launches headed south-southwest, flying over the gulf and a relatively short strip of a relatively sparsely inhabited region of Mexico before heading into the Pacific (and natural gas is a fraction of what it is in California, with a much friendlier regulatory environment). And Louisiana allows true private coastal ownership, unlike Texas, which requires public access to the waterfront. Anyway, I'm happy for SpaceX (for them, for our country, and for humanity). I hope they get to make the most of it. And I hope we get our day there, as well.

LOL. "Partnership with the NIH".

“If you're going to try, go all the way. Otherwise, don't even start.” ― Charles Bukowski

If the science is truly novel, expect resistance not applause.

In 1861, U.S. Grant was 39 years old, 5’8’’, 135 lbs, a professional failure, a drunk - and had no obvious prospects. A year later he commanded the federal army and won the Battle of Shiloh. In 1865 he defeated Robert E. Lee at Appomattox. In 1868 he was POTUS. Chin up always.


Three years since the first flight of Starship, the next generation is here. New ship. New booster. New engines. New pad and new test site. SpaceX engineers are working to solve one of the most difficult engineering challenges in history: developing a fully, rapidly reusable rocket





