David Sinclair

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SIRT6 is an NAD-dependent sirtuin that helps maintain chromatin structure, suppress inflammation, and stabilize the genome. This study shows again that loss of epigenetic organization during aging is not necessarily permanent

The most exciting finding: Increasing SIRT6, even late in life, restored youthful chromatin organization and rejuvenated the epigenome and the liver’s gene expression!

New! What if aging is a symptom of cells losing the ability to read their genome - and there’s a reset switch? That’s the idea behind the Information Theory of Aging (ITOA) A new paper @NatureComms by Cohen et al provides strong support for the model & its reversibility 🧵👇

Blindness. Frailty. Dementia. Hair loss What if they all had the same root cause & that cause was reversible? youtube.com/watch?v=pbvAA5…

The paper: cell.com/developmental-…

If so, what we once called junk DNA increasingly looks like regenerative software throughout the genome

For decades, transposons have been dismissed as a type of “junk” that causes aging & inflammation A fascinating new paper shows a flatworm transposon can improve regeneration by protecting stem cells from stress-induced death Could this be relevant to us? 🧵@CellCellPress

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The full @JoinLifespan Official Trailer is now live⚡️ 🔗lifespan.com/cdn/shop/video… 👉More at lifespan.com👨‍⚕️| @agingdoc1 🩺

Michael Pennington has died! Too soon We shall double our efforts

Why is everyone so obsessed with this longevity thing?

The field of longevity research has homed in on NAD+ as a potential therapy because of evidence that our levels decline as we get older, which may also contribute to the risks of age-related diseases, says Dr. Shalender Bhasin @ Brigham and Women's Hospital

Independent testing of NAD supplements like NR & NMN suggests there's considerable variability in the quality and what's on the label doesn't necessarily match what's in the product npr.org/2026/05/11/nx-…